Lightnews — Scholar-powered news

AACR Journals @aacrjournals.bsky.social · 7h

Check out this article in Cancer Immunology Research: buff.ly/wv7ZMSG

Using a CRISPR screen, the authors identify DYRK1A as a regulator of CD155 expression and show that targeting the PI3K/Akt pathway to reduce CD155 expression may help overcome resistance to PD-1 blockade in HNSCC.

AACR Journals @aacrjournals.bsky.social · 1d

Certain patients’ risk of developing #breastcancer in the future may be predicted by a genetic risk score, according to a new study from Kings College London researchers in Cancer Epidemiology, Biomarkers & Prevention. Learn more: buff.ly/Kg1yeOA

AACR Journals @aacrjournals.bsky.social · 1d

This study presents a novel genetic ancestry pipeline & applies it to assess model diversity in the PDXNet, identifying a need to diversify models for basic biological & precision medicine research.

Read the latest articles from this section: buff.ly/wh5gs5i

AACR Journals @aacrjournals.bsky.social · 1d

Concluding our Article Showcase is a featured selection from Melissa B. Davis, Senior Editor of Health Disparities and Outcomes Research: “Genetic Ancestry in PDXNet Models” buff.ly/jBtUKTA

1

Reposted by AACR Journals

American Association for Cancer Research (AACR) @theaacr.bsky.social · 3d

A series of papers published in the AACR journal Clinical Cancer Research shared key considerations for how to improve dosage optimization in oncology. Learn more on the AACR Blog: buff.ly/ZFH90e3

1 1

AACR Journals @aacrjournals.bsky.social · 2d

This study reports that females had a higher prevalence of specific comorbidities than males, suggesting that survivorship care should be tailored to age & gender for this common pediatric cancer.

Read the latest Epidemiology & Prevention articles: buff.ly/SRpmUtZ

AACR Journals @aacrjournals.bsky.social · 2d

Next up in our Article Showcase is a featured selection from Joya Chandra, Senior Editor of Epidemiology and Prevention: “Age and Sex Differences in the Prevalence of Specific Comorbidities among Patients with Pediatric ALL and LL at Diagnosis” buff.ly/R3Vz7BX

1

AACR Journals @aacrjournals.bsky.social · 3d

The authors report safety, tolerability, and efficacy data on sapanisertib in combination with metformin in patients with advanced solid tumors and mTOR/AKT/PI3K pathway alterations.

Read the latest Clinical Research and Trials articles: buff.ly/H3NDXiv

AACR Journals @aacrjournals.bsky.social · 3d

Up next in our Article Showcase is a featured selection from Eileen M. O’Reilly, Senior Editor of Clinical Research and Trials: “Sapanisertib plus Metformin in Metastatic Solid Tumors” buff.ly/RlwT75M

1 1

AACR Journals @aacrjournals.bsky.social · 4d

Congratulations to Editorial Board Member of Cancer Immunology Research Shimon Sakaguchi on his Nobel Prize.

Read more in #CancerDiscoveryNews

Regulatory T-Cell Pioneers Awarded Nobel Prize

By identifying regulatory T cells, this year’s Nobel laureates revealed a paradox at the heart of immunity: The same cells that prevent autoimmunity also suppress anticancer responses. That insight…

buff.ly

1

AACR Journals @aacrjournals.bsky.social · 4d

Sign up to receive alerts directly to your inbox to keep up with the latest published issues: buff.ly/O6OYSDp

1

AACR Journals @aacrjournals.bsky.social · 4d

The authors explore a novel two-cutoff approach that allows for splitting of patients when a non-monotonic relationship is present, modeling more complex relationships of TMB to outcome data.

Read the latest Precision Medicine and Biomarkers articles: buff.ly/MhmDeBX

AACR Journals @aacrjournals.bsky.social · 4d

The next featured selection in our Article Showcase is from Jakob N. Kather, Senior Editor of Precision Medicine and Biomarkers: “Characterization of Non-Monotonic Relationships between Tumor Mutational Burden and Clinical Outcomes” buff.ly/yheXp2g @jnkt.bsky.social

1

AACR Journals @aacrjournals.bsky.social · 5d

The authors developed an ADC that targets fibroblast activation protein (FAP) and sought to understand the mechanism behind FAP-targeted therapies.

Read the latest Therapeutic Research and Development articles: buff.ly/DuaSTEm

1

AACR Journals @aacrjournals.bsky.social · 5d

Next up in our Article Showcase is a featured selection from Alex Sparreboom, Senior Editor of Therapeutic Research and Development: “Mechanistic Characterization of CAF Depletion via an ADC Targeting Fibroblast Activation Protein” buff.ly/RuStSV4

1

AACR Journals @aacrjournals.bsky.social · 6d

In this recent Cancer Immunology Research article, the authors show that elevated infiltration of SPP1+ TAMs is related to worse response to immunotherapy and to dysfunction of CD8+ T cells in ccRCC. The data suggest SPP1 as a potential therapeutic target in ccRCC.

Read more: buff.ly/kC0UJ7y

1

AACR Journals @aacrjournals.bsky.social · 7d

Cancer Research Communications:

Methylation-Based ctDNA Tumor Fraction Changes Predict Long-Term Clinical Benefit From Immune Checkpoint Inhibitors in RADIOHEAD, a Real-World Pan-Cancer Study buff.ly/MOdpRuh

AACR Journals @aacrjournals.bsky.social · 7d

Molecular Cancer Therapeutics:

The Discovery and Characterization of HBS-101, a Novel Inhibitor of Midkine, as a Therapeutic Agent for the Treatment of Triple-Negative Breast Cancer buff.ly/gr907TU

1

AACR Journals @aacrjournals.bsky.social · 7d

Molecular Cancer Research:

Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT buff.ly/tuj6j8Y

1

AACR Journals @aacrjournals.bsky.social · 7d

Clinical Cancer Research:

Cemiplimab for Secondary Angiosarcomas buff.ly/7JJLfp6

Tarlatamab in Neuroendocrine Prostate Cancer buff.ly/DmfN9QR

1

AACR Journals @aacrjournals.bsky.social · 7d

Cancer Research:

Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models buff.ly/8wlFWnG

Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control buff.ly/mRR1JJ4

1

AACR Journals @aacrjournals.bsky.social · 7d

Cancer Prevention Research:

CervicalMethDx: A Precision DNA Methylation Test to Identify Risk of High-Grade Intraepithelial Lesions in Cervical Cancer Screening Algorithms buff.ly/istUE7m

1

AACR Journals @aacrjournals.bsky.social · 7d

Cancer Immunology Research:

Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies buff.ly/h0T7Ee9

1

AACR Journals @aacrjournals.bsky.social · 7d

Cancer Epidemiology, Biomarkers and Prevention:

The Effect of Circulating Proteins and Their Role in Mediating Adiposity’s Effect on Endometrial Cancer Risk: Mendelian Randomization and Colocalization Analyses buff.ly/Ri1cjGE

1

AACR Journals @aacrjournals.bsky.social · 7d

Cancer Discovery: Detection of Cancers Three Years prior to Diagnosis Using Plasma Cell-Free DNA buff.ly/ugnsVZI

1