Author | Lightnews

Alessandro Galloni @argalloni.bsky.social · 2d

Really enjoyed reading this short opinion piece by Tim O'Leary. I think it echoes the classic Feynman quote "what I cannot create I do not understand". I think engineering approaches such as neuromorphic computing will prove fundamental to scientific understanding of how biological brains work

Kyle @darsnack.bsky.social · 2d

Personal bias but I liked this transmitter article: www.thetransmitter.org/systems-neur...

“You won’t catch an engineer trying to formulate a grand unified theory of the brain”

“Engineers know how to make things work […] This is what makes engineering closer to biology than to other […] sciences”

Neuroscience needs engineers—for more reasons than you think

Adopting an engineering mindset will help the field focus its research priorities.

www.thetransmitter.org

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Reposted by Alessandro Galloni

Dan Goodman @neural-reckoning.org · 2d

Reminder this is happening this Wed/Thu. Free spiking neural network conference - registration required (see below).

Dan Goodman @neural-reckoning.org · 13d

Spiking NN fans - the #SNUFA workshop (Nov 5-6) agenda is finalised and online now. Make sure to register (free) soon. (Note you can register for either day and come to both.)

Agenda: snufa.net/2025/
Registration: www.eventbrite.co.uk/e/snufa-2025...

Thanks to all who voted on abstracts!

🤖🧠🧪

SNUFA 2025

Spiking Neural networks as Universal Function Approximators

snufa.net

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Reposted by Alessandro Galloni

Eddy Rhodes @eddycurrents.bsky.social · 8d

My co-authors have yet to move to Bluesky, so I'm pleased to announce our latest work has just been published in @nature.com Neuroscience. Amazing work led by Junheng Li, revealing that falling asleep follows a predictable bifurcation pattern #neuroskyence #sleep
www.nature.com/articles/s41...

Falling asleep follows a predictable bifurcation dynamic - Nature Neuroscience

Li et al. propose a conceptual framework to study the phenomenon of falling asleep based on electroencephalogram data. They show that a tipping point marks the brain’s nonlinear wake-to-sleep transiti...

www.nature.com

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Reposted by Alessandro Galloni

Ida Momennejad @neuroai.bsky.social · 9d

MSR NYC is hiring senior researchers in AI, both broadly in AI/ML & in specific areas (post-training, test-time scaling, modular transfer learning, science of deep learning).
aka.ms/msrnyc-jobs

We're reviewing on a rolling basis, interviews in Nov/Dec. Please apply here: tinyurl.com/MSRNYCjob

Microsoft Research Lab - New York City - Microsoft Research

Apply for a research position at Microsoft Research New York & collaborate with academia to advance economics research, prediction markets & ML.

aka.ms

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Alessandro Galloni @argalloni.bsky.social · 15d

Ah nice, that's a good trick

Alessandro Galloni @argalloni.bsky.social · 16d

Good tips! The only thing I dislike about this workflow is that the ai file with links is no longer self-contained, so harder to share with collaborators. I usually go straight for multi-panel in python (using Gridspec), and only use illustrator for adding the panel letters

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Reposted by Alessandro Galloni

Guido Meijer @guidomeijer.com · 21d

Want to make publication-ready figures come straight from Python without having to do any manual editing? Are you fed up with axes labels being unreadable during your presentations? Follow this short tutorial including code examples! 👇🧵

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Reposted by Alessandro Galloni

Dr. Kareem Carr, Ph.D. @kareemcarr.bsky.social · 21d

Check out my new article: vitalstatistics.kareemcarr.com/p/a-simple-e...

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Reposted by Alessandro Galloni

Dan Goodman @neural-reckoning.org · Oct 1

Message for participants of the #SNUFA 2025 spiking neural network workshop. We got almost 60 awesome abstract submissions, and we'd now like your help to select which ones should be offered talks. Follow the "abstract voting" link at snufa.net/2025/ to take part. It should take <15m. Thanks! ❤️

SNUFA 2025

Spiking Neural networks as Universal Function Approximators

snufa.net

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Reposted by Alessandro Galloni

Jason Shepherd @jasonsynaptic.bsky.social · 29d

#goals

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Reposted by Alessandro Galloni

Fatemeh_Hadaeghi @fatemehhadaeghi.bsky.social · Oct 6

A thought-provoking perspective from the visionary @giacomoi.bsky.social, calling for neuromorphic computing to return to its root: fundamental neuroscience; an inspiring vision for the future of NeuroAI 🤩

Neuron @cp-neuron.bsky.social · Oct 3

Neuromorphic is dead. Long live neuromorphic

In this NeuroView, Giacomo Indiveri discusses the origins and evolution of neuromorphic engineering, reflects on recent shifts toward digital and AI-centric approaches, and advocates for a revival of the field’s original principles, emphasizing analog, brain-inspired systems and the importance of fundamental neuroscience for future progress.

dlvr.it

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Reposted by Alessandro Galloni

Lea Duncker @leaduncker.bsky.social · Oct 3

Travel awards are available for undergraduate students looking to attend #Cosyne25! The application is short, and the deadline is Nov 12. @cosynemeeting.bsky.social

Application: shorturl.at/6NEyk

More info: www.cosyne.org/travel-grants

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Travel Grants — COSYNE

Apply for COSYNE 2026 Travel Grants to support your participation in Lisbon and Cascais, Portugal. Grants are available for students, postdocs, and PIs, including programs for Childcare, Presenters, N...

www.cosyne.org

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Reposted by Alessandro Galloni

Kris Jensen @kristorpjensen.bsky.social · Sep 24

I’m super excited to finally put my recent work with @behrenstimb.bsky.social on bioRxiv, where we develop a new mechanistic theory of how PFC structures adaptive behaviour using attractor dynamics in space and time!

www.biorxiv.org/content/10.1...

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Alessandro Galloni @argalloni.bsky.social · Sep 23

Q: In current clamp, does the delivered current get filtered by Rs?

A: No, the current is truly a square step with accurate amplitude and timing (as long as you don’t saturate the op-amp). The main source of error here is the current leaking out through a bad seal.

Alessandro Galloni @argalloni.bsky.social · Sep 23

Q: In V-clamp (without compensation), does the cell membrane charge up slowly according to the membrane timeconstant tau=Rm*Cm?

A: No, the membrane charges up slowly according to tau=Rs*Cm, i.e. the speed of charging depends on *series resistance (Rs)*, not the membrane/leak resistance Rm.

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Alessandro Galloni @argalloni.bsky.social · Sep 23

Q: The pipette capacitance (Cp) causes an RC filtering/transient. Does “R” here refer to the pipette resistance? Will smaller pipette opening affect the capacitive artifact?

A: No, the R here is neither the Rs nor Rleak. It is the sum or resistances in *series* with Cp (e.g. junction resistance)

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Alessandro Galloni @argalloni.bsky.social · Sep 23

Q: Does access R affect the recorded voltage in current clamp if I'm not injecting current?

A: There is no DC error if you are not passing current, but the waveform is still affected by the pipette capacitance (tau=Rs*Cp), making fast events like APs smaller and wider

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Alessandro Galloni @argalloni.bsky.social · Sep 23

And here are some more FAQs ((I encourage students to not take my word for it, but verify these things for yourself with the simulator!):

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Alessandro Galloni @argalloni.bsky.social · Sep 23

Here are a few other great resources I came across while building this:
www.billconnelly.net?p=310
swharden.com/blog/2020-10...
www.bio.ens.psl.eu/~barbour/

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Alessandro Galloni @argalloni.bsky.social · Sep 23

Here is the link to the simulator if any of you want to play with it. Or share it with your students if they are learning about electrophysiology!
tinyurl.com/patch-clamp-...

I added sliders to let you easily play around with all the key variables (series/access R, Rs, capacitance comp, etc)

tinyurl.com

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Alessandro Galloni @argalloni.bsky.social · Sep 23

Electronics can be pretty unintuitive. I've found that being able to directly see and manipulate all the variables in a "white-box" system like this makes it much easier to grok what is going on under the hood. Active learning ftw!

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Alessandro Galloni @argalloni.bsky.social · Sep 23

On the other hand, Rs compensation in Voltage Clamp is an active circuit that directly drives the cell voltage higher (so it's very important to get it right online!)

Because of the positive feedback loop (command voltage driven by recorded current), it is prone to unstable oscillations.

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Alessandro Galloni @argalloni.bsky.social · Sep 23

For example, does bridge balance compensation affects how much current is being delivered to the cell?

Answer: no, bridge balance is a cosmetic DC correction to the recorded voltage (proportional to delivered current). It doesn't influence anything about the actual pipette/cell/injected current

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Alessandro Galloni @argalloni.bsky.social · Sep 23

Many students (and practitioners!) get confused about how series resistance, pipette capacitance, and various electronic compensation circuits affect your recordings.

Now you can see for yourself in the simulator!
tinyurl.com/patch-clamp-...

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Alessandro Galloni @argalloni.bsky.social · Sep 23

Hey ephys friends! I've been teaching electrophysiology for a few years now, and this summer while teaching at CSHL I started building an interactive simulation of a full patch-clamp amplifier circuit to help explain electronics to my students.

Sharing it here in case anyone finds it useful!

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