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Dr. Arun Sethuraman

@arunsethuraman.bsky.social

3K followers 3.3K following 490 posts

Computational evolutionary biologist. Associate Professor at @sandiegostate.bsky.social, athlete, insomniac, writer, singer, polyglot, polymath. He/him. 🏳️‍🌈🇮🇳🇺🇸🐞🌱🐢🧬🏋🏾‍♂️🎤✍🏾 www.sethuramanlab.com Views are mine and mine alone.

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Dr. Arun Sethuraman @arunsethuraman.bsky.social · 10d

Do check out our new manuscript, now out in G3 on modelling theoretical expectations of ghost introgression in sampled genomes. Just in time for Halloween! 🎃 👻

Genetics Society of America @genetics-gsa.bsky.social · 11d

New in #G3journal: @arunsethuraman.bsky.social et al. describe biases in summary statistics, such as genetic differentiation, diversity, Tajima’s D, and estimates of theta, migration rates, and divergence for understanding genomic signatures from extinct ghost populations. buff.ly/7fGnPXj

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Dr. Arun Sethuraman @arunsethuraman.bsky.social · 20h

Also for those of you purchasing big ticket items - our wonderful nation’s tariffs have now increased the ‘actual’ costs significantly. So please budget 10-25% of your total quoted costs for each item.

Dr. Arun Sethuraman @arunsethuraman.bsky.social · 21h

Wow - startup expires soon; fastest $$$$$ I’ve spent, ever! Sorry but I’m not giving my money back to you, any more than what I already do, State of CA. Now we will have enough long and short read genomes to last my lab at least 5 years. And 2 new GPU nodes, 2 CPU nodes and a fancy NFS.

a woman carrying shopping bags in a parking lot with the words just got a few things above her

ALT: a woman carrying shopping bags in a parking lot with the words just got a few things above her

media.tenor.com

Dr. Arun Sethuraman @arunsethuraman.bsky.social · 21h

a woman carrying shopping bags in a parking lot with the words just got a few things above her

ALT: a woman carrying shopping bags in a parking lot with the words just got a few things above her

media.tenor.com

Reposted by Dr. Arun Sethuraman

Martin A. Nuñez @martin-nunez.bsky.social · 1d

www.nature.com/articles/d41...

More than 30% of this century’s science Nobel prizewinners immigrated: see their journeys

The most common destination for eventual Nobel laureates in physics, chemistry and medicine since 2000 is the United States, Nature has found.

www.nature.com

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Dr. Arun Sethuraman @arunsethuraman.bsky.social · 1d

Time for me to download Zoho’s Arattai (means banter in my mother tongue Tamizh) methinks. WhatsApp (and Meta) can go to shit for all I care.

Forbes @forbes.com · 2d

The app, named “Arattai,” leads the Google Play Store and Apple App Store rankings in India, buoyed by a government push for “Made-in-India” platforms amid trade tensions with the U.S.

WhatsApp Rival In India Is Boosted By Modi’s Calls For ‘Self-Reliance’ Amid U.S. Tariff Battle

The app, named “Arattai,” leads the Google Play Store and Apple App Store rankings in India, buoyed by a government push for “Made-in-India” platforms amid trade tensions with the U.S.

www.forbes.com

Dr. Arun Sethuraman @arunsethuraman.bsky.social · 1d

Always such a pleasure to have Pat Walls, a certified cicerone, food historian, and Director of the North American Guild of Beer Writers stop by my Research Methods class to talk about beer and hop sensory analyses. Plus the beer wasn’t bad either!

Dr. Arun Sethuraman @arunsethuraman.bsky.social · 1d

Lmao! This is so me. Did they do a good job with though? If so, referral please!

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Reposted by Dr. Arun Sethuraman

Daniel Bolnick @danielbolnick.bsky.social · 2d

@sse-evolution.bsky.social just announced the following:

Call for Proposals: Research Synthesis Working Groups
The Society for the Study of Evolution (SSE) invites proposals for sponsored Research Synthesis Working Groups at the 2026 Evolution meeting (up to two in-person and one virtual). ...

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Dr. Arun Sethuraman @arunsethuraman.bsky.social · 2d

Visited my PCP since I have been so stressed out & on a short fuse lately (worried if my escitalopram dosage was off). He says the dosage is fine, and that I'm the problem. I just need a lower dosage of the daily disastrous news and a new therapist.

garfield looking at his reflection in a mirror with the nick logo in the background

ALT: garfield looking at his reflection in a mirror with the nick logo in the background

media.tenor.com

Reposted by Dr. Arun Sethuraman

Brent Emerson @brentcemerson.bsky.social · 2d

!!!
www.nature.com/articles/s41...

Archived natural DNA samplers reveal four decades of biodiversity change across the tree of life - Nature Ecology & Evolution

This study explores four decades of biodiversity change across the tree of life in Germany’s terrestrial and aquatic ecosystems by sequencing standardized biota samples from a long-term pollution monitoring archive.

www.nature.com

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Reposted by Dr. Arun Sethuraman

Boas Pucker @bpucker.bsky.social · 2d

Excited to share our new preprint!

🧬 Large-scale Phylogenomics Reveals Systematic Loss of Anthocyanin Biosynthesis Genes at the Family Level in Cucurbitaceae

👉 doi.org/10.1101/2025...

A deep dive into the genomic evolution of color in cucurbits 🎃🍉 — feedback welcome!
@puckerlab.bsky.social

Synteny plots supporting loss of DFR, ANS, and arGST in Cucurbitaceae. Reference: https://doi.org/10.1101/2025.10.06.680802

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Reposted by Dr. Arun Sethuraman

Matthew Neville @mattneville.bsky.social · 3d

Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...

Sperm sequencing reveals extensive positive selection in the male germline - Nature

A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

www.nature.com

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Reposted by Dr. Arun Sethuraman

Hanbin Lee @epigenci.bsky.social · 2d

Our paper (Brieuc Lehmann is the first author) is now online in Genetics.

academic.oup.com/genetics/adv...

On ARGs, pedigrees, and genetic relatedness matrices

Abstract. Genetic relatedness is a central concept in genetics, underpinning studies of population and quantitative genetics in human, animal, and plant se

academic.oup.com

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Reposted by Dr. Arun Sethuraman

April Wei @aprilwei.bsky.social · 3d

Excited to preprint our latest work (w/ Drew DeHaas, Zhibai Jia, Leo Speidel) on using ARGs for demographic inference. w/ applications using data from 1000 Genomes Project. www.biorxiv.org/content/10.1...

Inference of complex demographic history using composite likelihood based on whole-genome genealogies

Accurate parametric inference on complex demographic models is a continuing challenge in population genetics. Ancestral recombination graphs (ARGs) provide richer information than simple population ge...

www.biorxiv.org

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Dr. Arun Sethuraman @arunsethuraman.bsky.social · 3d

My PhD student @megwanjiku.bsky.social's MS work on population genomics of rice blast in Sub Saharan Africa was just published! Congrats to her! She's on a roll - that's manuscript #3 for her this year, with her PhD Chapter 1 (#4) coming soon! doi.org/10.3389/fpls...

Frontiers | Genomic profiles of Pyricularia oryzae in Sub-Saharan Africa: exploring population differences and their evolutionary implications in the region

BackgroundRice blast, caused by Pyricularia oryzae (teleomorph: Magnaporthe oryzae), is one of the most economically damaging diseases affecting rice worldwi...

doi.org

Reposted by Dr. Arun Sethuraman

Trends in Ecology & Evolution @cp-trendsecolevo.bsky.social · 4d

October issue out now! www.cell.com/trends/ecolo...

Cover article by Guan-Long Cao, Wei Wang and colleagues looking at the biodiversity on the largest continuous mountain belt on Earth.

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Reposted by Dr. Arun Sethuraman

Evolutionary Ecology Group, Cambridge @eegcam.bsky.social · 4d

#newpreprint: "Climate Shaped the Global Population Structure of Leopards and their Extinction in Europe": www.biorxiv.org/content/10.1...! Leopards are charming big cats but there are many mysteries around them. Thread 🧵

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Reposted by Dr. Arun Sethuraman

Wallace Marshall @wallaceucsf.bsky.social · 4d

Are you in/near the SF Bay Area? Do you like Science? What about Festivals? Then you might want to check out the Bay Area Science Festival Oct 25. I’ll be there showing how single cells can learn!

www.bayareasciencefestival.org

Home - Bay Area Science Festival

Bring the whole family to experience 100+ jaw-dropping demonstrations, hands-on experiments, astounding games, behind the scenes lab tours, film screenings

www.bayareasciencefestival.org

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Reposted by Dr. Arun Sethuraman

Matt Holt @holtjma.bsky.social · 5d

I'm excited to share our pre-print about a new variant benchmarking tool we've been working on for the past few months!

Aardvark: Sifting through differences in a mound of variants
GitHub: github.com/PacificBiosc...

Some highlights in this thread:
1/N

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Dr. Arun Sethuraman @arunsethuraman.bsky.social · 4d

This week in the @calstate.bsky.social bioinformatics webinar series! Yours truly - I’ll update y’all on recent work from my lab on addressing missing data problems in pop-gen. Friday, 10/10 at noon PST! Do join us via Zoom. Deets in flyer.

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Reposted by Dr. Arun Sethuraman

Mia Levine @levine-lab.bsky.social · 7d

Check out this new Levine-Lampson collaboration, led by the talented Hyuk-Joon Jeon.

We explored the consequences of inheriting long telomeres from dad and short telomeres from mom. Or the reciprocal. Turns out, parent-of-origin matters (in mice, at least).

authors.elsevier.com/c/1loW-3QW8S...

authors.elsevier.com

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Reposted by Dr. Arun Sethuraman

WeRateDogs @weratedogs.com · 8d

Here are the Top 5 Dogs of the week!

61 630 4K

Dr. Arun Sethuraman @arunsethuraman.bsky.social · 8d

Re-upping this. Do join us via Zoom today at noon PST!

Dr. Arun Sethuraman @arunsethuraman.bsky.social · 9d

Next up in our @calstate.bsky.social Bioinformatics Webinar series - we welcome Dr. Pedro J. Torres, Director of Bioinformatics and Data Science at Persephone Biosciences. Dr. Torres is also an alum of @sandiegostate.bsky.social! Do join us - 10/3 at noon PST via Zoom: sdsu.zoom.us/j/88624423158

Dr. Arun Sethuraman @arunsethuraman.bsky.social · 8d

Woke up to Calvin giving me brekky eyes. Think he needs something?

Reposted by Dr. Arun Sethuraman

Journal of Systematics and Evolution @journalsysevo.bsky.social · 8d

In this systematic performance evaluation of #STRUCTURE, the most popular #population clustering method, Xiao-Xu Pang and Da-Yong Zhang offer praise--but also caution.
Find out why!⬇️

doi.org/10.1111/jse....

#JSE #evolution #technology #systematics

A cautionary note on using STRUCTURE to detect hybridization in a phylogenetic context

Using simulations, we provide the first systematic evaluation of the performance of STRUCTURE under a variety of cross-species hybridization scenarios. We find that STRUCTURE performs well in identif...

doi.org

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Dr. Arun Sethuraman @arunsethuraman.bsky.social · 8d

No legit reason - just didn’t share. I serve on a hundred committees; definitely not keeping track of when every single one is defending or sending me docs. But when they do, I make the time to read it. I definitely don’t appreciate the random troll advice. Thanks.