Author | Lightnews

Auclair Lab @auclairlab.bsky.social · 7d

From the Auclair lab: Dr. Jacob Pierscianowski, Dr. Dustin Duncan, Dr. Blue Lan, Dr. Rohit Kholiya, Suzana Diaconescu-Grabari, Ahmed B. Abdelaal, Aracelli Chang, Shay Heans, Dr. Sanjay Campbell, Dr. Alexandre Pierret.

With collaboration from the groups of Profs. Schmeing, Findlay, and Lupien.

Auclair Lab @auclairlab.bsky.social · 7d

NEW PREPRINT:

An extensive structure-activity relationship investigation of pantetheinamides and their ability to inhibit Salmonella typhimurium.

We investigate the mechanisms of action of these compounds and their use with in vivo mouse models.

doi.org/10.1101/2025...

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Auclair Lab @auclairlab.bsky.social · 14d

Here's some more balanced centrifuge arrangements #chemsky

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Auclair Lab @auclairlab.bsky.social · 27d

We're incredibly proud to announce Dr. Jacob Pierscianowski has officially defended his PhD thesis!
Congratulations to Dr. Jake on the amazing work.

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Auclair Lab @auclairlab.bsky.social · 29d

Good Wordle yesterday.

Auclair Lab @auclairlab.bsky.social · Oct 4

Update: purified it anyways. Fraction looks reasonably pure. Now let's see the activity tests. #chemsky

Auclair Lab @auclairlab.bsky.social · Sep 23

Admin got up yesterday at 7 in the morning to perform a transformation that probably didn't work. One (1) colony on the plates. This is the #chembiosky life.

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Auclair Lab @auclairlab.bsky.social · Oct 3

The Auclair Lab welcomes two new members!

Maya Gaylor, co-supervised by Prof. Lupien in Microbiology and Immunology, will be working on our antimicrobial projects.

Dr. Alana Rangaswamy is a recent graduate from the Keillor lab @uottawa.ca and will focus on enzyme and depolymerization efforts.

Auclair Lab @auclairlab.bsky.social · Sep 23

Admin got up yesterday at 7 in the morning to perform a transformation that probably didn't work. One (1) colony on the plates. This is the #chembiosky life.

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Auclair Lab @auclairlab.bsky.social · Sep 19

Fun fact: we scheduled our lab cleanup day a few weeks ago, and the second we finished up, we got a notification that we were having a safety inspection the very next Monday.

Talk about good timing #chemsky

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Auclair Lab @auclairlab.bsky.social · Sep 12

Many members of the Auclair lab hosted and attended the student-led Careers After Chemistry conference! #CAC2025 #chemsky

Auclair Lab @auclairlab.bsky.social · Sep 10

Literal green chemistry #chemsky

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Auclair Lab @auclairlab.bsky.social · Sep 4

Doing a little setup for our new baby 👀

Auclair Lab @auclairlab.bsky.social · Sep 3

New instrument 🔜🔜🔜

Auclair Lab @auclairlab.bsky.social · Aug 29

Sign up for McGill Chemistry's Careers After Chemistry 2025 conference! Registration ends September 5.

cacmcgill.wixsite.com/cac2025/regi...

Register | CAC 2025

cacmcgill.wixsite.com

Auclair Lab @auclairlab.bsky.social · Aug 28

The Auclair lab went tree trekking recently! Super fun teambuilding exercise.

Auclair Lab @auclairlab.bsky.social · Aug 20

Very happy to meet 2020 Nobel Prize laureate @e-charpentier.bsky.social at @ircm.bsky.social!

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Reposted by Auclair Lab

Auclair Lab @auclairlab.bsky.social · Aug 13

‼️NEW PAPER ALERT

In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU.
doi.org/10.1128/aac....
🧵

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Reposted by Auclair Lab

Bromothymol Blue @canvasblue.bsky.social · Aug 13

Another day, another paper 😌

Auclair Lab @auclairlab.bsky.social · Aug 13

‼️NEW PAPER ALERT

In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU.
doi.org/10.1128/aac....
🧵

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Auclair Lab @auclairlab.bsky.social · Aug 13

- Our pantothenamide mimics avoid degradation by pantetheinases thanks to the bond substitution

- Sub-micromolar antiplasmodial activity in vitro

- Excellent selectivity for plasmodial enzymes vs. human enzymes

- Computational analysis included to gain insight into SARs

Auclair Lab @auclairlab.bsky.social · Aug 13

Key notes:

- Made possible by Annica Chu, Dr. Mina Nekouei, Dr. Blue Lan, and Dr. Alexandre Pierret of the Auclair lab, in collaboration with Xiangning Liu from the group of Prof. Kevin J. Saliba

- These molecules follow the parasite CoA pathway and become potent, low-cytotoxicity antimetabolites

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Auclair Lab @auclairlab.bsky.social · Aug 13

‼️NEW PAPER ALERT

In Antimicrobial Agents and Chemotherapy, we replace an enzyme-vulnerable amide bond with a thiazole to produce potent antiplasmodial and antimalarial pantothenamide mimics. A collaboration between the Auclair lab @mcgill.ca and the Saliba lab at ANU.
doi.org/10.1128/aac....
🧵

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Auclair Lab @auclairlab.bsky.social · Aug 11

Balloons! #chemsky

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Auclair Lab @auclairlab.bsky.social · Aug 7

Finding the volume of our milling balls: if it was good enough for Archimedes, it's good enough for grad students #chemsky

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Auclair Lab @auclairlab.bsky.social · Jul 30

A wonderful moist-solid #chemsky

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Auclair Lab @auclairlab.bsky.social · Jul 18

It's gel day #chemsky

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