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Reposted by Phil Kyriakakis

Grant Jacobs BioinfoTools/NotJustDNA 🔬🧬🖥️✍️📚 @notjustdna.bsky.social · 18h

🧪 I’d have never guessed it either ⬇️

Anne Carpenter @drannecarpenter.bsky.social · 1d

15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵

mitochondria from bipolar patients are closer to the nucleus in these images; control patients' are spread out further

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Phil Kyriakakis @breakliquid.bsky.social · 10h

Wow. A family member got but by a tick recently and had psychosis as a result. Not from Lyme disease or an infection. I think she went to several Boston hospitals including McLean. Perhaps it is just a coincidence, but i kept wondering how a tick bite could affect the brain. 🧠

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Phil Kyriakakis @breakliquid.bsky.social · 10h

@zebrafishrock.bsky.social does anyone here study age-related vision loss in fish? Or vision generally?

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Phil Kyriakakis @breakliquid.bsky.social · 2d

Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope
www.nature.com/articles/s41...

Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope - Nature Communications

Loretan and colleagues present a low-cost smartphone-based microscope capable of detecting single-molecule fluorescence. This approach opens doors to personalised and widely distributed applications in diagnostics, biosensing, and science education.

www.nature.com

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Phil Kyriakakis @breakliquid.bsky.social · 4d

Smile 😃

Daniel Pomarède @pomarede.bsky.social · 4d

#APOD Astronomy Picture of the Day

SN Encore: A Second Supernova Seen Several Times

Credits: NASA, ESA, CSA, STScI, J. Pierel (STScI) & A. Newman (Carnegie Inst. for Science) 🧪🔭
www.star.ucl.ac.uk/~apod/apod/a...

Through a gravitational lens effect caused by a massive foreground cluster of galaxies (MACS J0138), multiple images of a perfectly aligned background galaxy (MRG-M0138) are created, including the supernova Encore it hosts. This image was captured by JWST in 2023.

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Reposted by Phil Kyriakakis

lenint.bsky.social @lenint.bsky.social · 5d

🧪"In doing so, Arnold has mastered the art of a good apology: one that doesn’t veer into excusing oneself; that gives context where relevant; but accepts full responsibility and moves on".

www.theguardian.com/science/2020...

Nobel prize winner demonstrates the best way to apologize

Unfortunately there aren’t Nobel prizes for good apologies – but Dr Frances Arnold’s words should be an example to all of us

www.theguardian.com

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Phil Kyriakakis @breakliquid.bsky.social · 6d

WAChRs are excitatory opsins sensitive to indoor lighting

www.biorxiv.org/content/10.1...

WAChRs are excitatory opsins sensitive to indoor lighting

Hundreds of novel opsins have been characterized since the advent of optogenetics, but low experimental throughput has limited the scale of opsin engineering campaigns. We modified an automated patch-...

www.biorxiv.org

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Reposted by Phil Kyriakakis

Chise @sailorrooscout.bsky.social · 7d

Their efficacy was confirmed against LIVE viruses including Ebola, Marburg, Nipah, Hendra, SARS-CoV, SARS-CoV-2 (COVID-19), AND Middle East Respiratory Syndrome (MERS).

The study has been published in Science Advances. YES, it is PEER-REVIEWED.
• www.science.org/doi/10.1126/...

🧪🧵⬇️

ABSTRACT
Viral pandemics continue to threaten global health and economic stability. Despite medical advances, the absence of broad-spectrum antivirals (BSAs) prevents rapid responses to emerging viral threats. This is largely due to the lack of universal drug targets across diverse viral families and high variability among viral proteins.
In this study, we evaluated 57 synthetic carbohydrate receptors (SCRs) for antiviral activity in cellulo using pseudotyped virus particles (PVPs) from six high-risk viruses across three families: Paramyxoviridae, Filoviridae, and Coronaviridae.
Four SCRs inhibited all tested PVPs, and their efficacy was confirmed against live viruses including SARS-CoV-2, MERS-COV, EBOV, MARV, NiV, and HeV.
Notably, SCR005 and SCR007, which exhibited minimal toxicity, significantly reduced SARS-CoV-2 infection in a severe animal model with a single dose.
Mechanistic studies suggested that SCRs bind viral envelope N-glycans, blocking viral attachment and/or fusion.
These results identify conserved viral N-glycans as promising BSA targets and establish SCRs as candidate prophylactic agents against enveloped viruses with pandemic potential.

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Phil Kyriakakis @breakliquid.bsky.social · 8d

The birds might not be so happy about this 😆

Reposted by Phil Kyriakakis

Oded Rechavi @odedrechavi.bsky.social · 12d

Got to love studies that were clearly conducted "for the love of the game" (“self-decapitating sea slugs”, “plants that see and use that for mimicry”, “worms that jump in the air”, aka papers you sometimes find in @currentbiology.bsky.social
) References to all of this bellow👇

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Phil Kyriakakis @breakliquid.bsky.social · 13d

Very cool!

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Phil Kyriakakis @breakliquid.bsky.social · 14d

Do tell!

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Phil Kyriakakis @breakliquid.bsky.social · 14d

“Must be the water”

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Phil Kyriakakis @breakliquid.bsky.social · 14d

The emperor has no followers

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Phil Kyriakakis @breakliquid.bsky.social · 14d

Synthetic biology

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Phil Kyriakakis @breakliquid.bsky.social · 14d

Its not just my cat…

Phil Kyriakakis @breakliquid.bsky.social · 14d

I hope my algorithm can regenerate too

Oded Rechavi @odedrechavi.bsky.social · 15d

It's probably the deterioration of social media (I hope) but i'm exposed to a lot less cool science. It used to feel like a new cool study is being preprinted/published every week, and lately it's rare (at least so it seems). Share a recent study that's worth knowing!