Lightnews — Scholar-powered news

Reposted by The Brigant Lab

The European Alliance of Associations for Rheumatology @eular.org · Jun 16

🎥Access the #EULAR2025 Congress on-demand and watch inspiring Scientific Sessions from Monday 16 June until 31 December 2025!

Registration deadline: 30 June 2025, 23:59 CEST

Register here: https://pulse.ly/onsw7zxrcf

#Rheumatology #EULAR

3 6

The Brigant Lab @brigantlab.bsky.social · Jun 16

Hi, these are screenshots from the conference. Do you want the patchwork we shared or all the screenshots? (Dav)

Reposted by The Brigant Lab

Simon Stones @simonrstones.bsky.social · Jun 13

Fatigue has a considerable impact on the daily lives of people living with RMDs and their families #eular2025

2 4

The Brigant Lab @brigantlab.bsky.social · Jun 13

@karinasturm.bsky.social Thanks again for our interesting exchange (Benjamin)!

1 2

The Brigant Lab @brigantlab.bsky.social · Jun 13

Yesterday at #EULAR2025, we explored Ehlers-Danlos syndrome (EDS): its diagnosis, pathways, therapies, and comorbidities. Inspiring insights into this complex condition! 🦓🌍💡✨
#EULAR2025 #EDS #ehlersdanlossyndrome
#rheumaticdiseases #brigantlabonthemove #BehindBrigantLab #MedSky #AcademicSky

1 9

Reposted by The Brigant Lab

Anna Fryxelius @annafryxelius.bsky.social · Jun 11

🧪✨ Proud to represent Norsk Revmatikerforbund at #EULAR2025 with four posters on patient-led research!

Here with poster #1 - presenting at A08 at 15:30 today 😃

🔹 Poster 1: Top 10 research priorities in Rheumatoid Arthritis – identified through a participatory James Lind Alliance process:

Anna Fryxelius, a woman in a wheelchair is smiling and pointing enthusiastically at a scientific poster behind her. The poster, titled “Structured patient involvement in Rheumatoid Arthritis research,” is presented by the Norwegian Rheumatism Association (Norsk Revmatikerforbund) at the EULAR Congress. It highlights the top 10 unanswered research questions in rheumatoid arthritis and describes a James Lind Alliance priority-setting process. The woman is wearing a black suit and conference badge, and the setting is a professional blue-carpeted conference hall.

4 2 10

The Brigant Lab @brigantlab.bsky.social · Jun 11

Hello from EULAR 2025! 🏛️✨ Ready to explore, connect, and learn in Barcelona. 🌍🔬
#EULAR2025 #BrigantLab #ScienceInBarcelona #osteoarthritis #MedSky #AcademicSky

1 5

The Brigant Lab @brigantlab.bsky.social · May 17

Gratulerer med dagen for 17 mai ! 🇳🇴🎊✨

1 3

The Brigant Lab @brigantlab.bsky.social · May 13

#InsideBrigantLab How do aging cells drive joint damage?🤔
In osteoarthritis, chondrocytes lose their repair abilities and release proteins that accelerate cartilage breakdown, fueling joint degeneration. 🦴

Stay tuned for more insights ! 💡 #MedSky #AcademicSky #cellularbiology #BrigantLab

🌟 Inside Brigant Lab : The chondrocytes cells 🌟

Have you ever wondered how aging cells contribute to joint damage?
Let’s dive into the science together! 🧠💡

Meet the chondrocytes, the architects of cartilage health, maintaining its structure and function. But in osteoarthritis (OA), their balance is disrupted. These cells start contributing to cartilage breakdown, driving joint degeneration. As they age, chondrocytes lose their ability to repair cartilage and produce proteins that accelerate its destruction—worsening joint damage and fueling the progression of OA. Understanding their role is key to unlocking new treatments. 🧬🦴✨

Image: Chondrocyte cells in 2D culture

Want to know more?

Stay tuned for more #InsideBrigantLab posts, where we’ll share insights into our research and an exclusive preview of what’s next in our scientific journey. 🔍

#CellularBiology #chondrocyteresearch #osteoarthritis #science #research #ArthritisAwarenessMonth #MolecularMedicine#sciencecommunication#lablife #brigantlab #insidebrigantlab

1 5

The Brigant Lab @brigantlab.bsky.social · May 6

👀 Curious about what happens at Brigant Lab?

Follow our new series: #InsideBrigantLab!

Explore our research, discoveries, and beyond. 🧬💡😃

#osteoarthritis #AcademicSky #MedSky #Science #Research #lablife #InsideBrigantLab

🌟 Welcome to InsideBrigantLab! 🌟

In this series, we’ll take you behind the scenes of our lab’s journey to advance diagnostics and develop innovative treatments for rheumatologic diseases.🔬💊📖

Our first feature focuses on Osteoarthritis (OA), the most common form of arthritis—a condition that wears down joint cartilage over time. Think of cartilage as the cushion between your joints. In OA, that cushion wears thin, leading to pain and stiffness. OA affects millions worldwide and significantly reduces quality of life. 🦴♿

Did you know that by 2050, 1 in 3 people may be living with OA? Understanding its symptoms, prevalence, and the current limitations in treatments is crucial for driving innovative research. 💡

While prevention strategies exist, effective disease-modifying treatments remain a significant unmet need—and this is where our work comes in.
At BrigantLab, we’re diving deep into the molecular mechanisms of OA, with a special focus on the role of chondrocytes and connective tissues.🧬🩺

Stay tuned for more #InsideBrigantLab posts, where we’ll share insights into our work, the impact we strive to create, and an exclusive preview of what’s next in our scientific journey. Have questions or topics you’d like us to explore? Let us know! 😊

#osteoarthritis #osteoarthritisawareness #rheumaticdisease #chondrocyteresearch #molecularmedicine #research #sciencecommunication #BrigantLab #InsideBrigantLab

3

The Brigant Lab @brigantlab.bsky.social · May 2

May is #ArthritisAwarenessMonth A global initiative to highlight the impact of rheumatic & musculoskeletal diseases. At Brigantlab, we're advancing osteoarthritis research to improve lives. Join us in spreading awareness and hope.💚 #Osteoarthritis #RheumaticDiseases #MedSky #AcademicSky #BrigantLab

💚 May is Arthritis Awareness Month! 💚

Arthritis Awareness Month is a global initiative to raise awareness about the impact of rheumatic and musculoskeletal diseases (RMDs), which affect millions of lives worldwide. 🌍

At Brigantlab, we’re shining a light on osteoarthritis (OA)—a common form of arthritis that impacts joints like the knees, hips, and hands. For those living with OA, chronic pain, stiffness, and reduced mobility are daily challenges.🦵🤲

For over 500 million people, OA means chronic pain, stiffness, and reduced mobility, but together, we can make a difference. 💥

🔬 Our research dives deep into how chondrocytes (the cells in cartilage) respond under pathological conditions. With every discovery, we’re closer to better diagnosis, treatments, and hope for those affected.🧬

Let’s remember:
✅ OA doesn’t discriminate—it can affect anyone, at any age.
✅ It’s life-changing, but through awareness and innovation, we can fight back.
✅ Research is the key to unlocking a better future.

Join us this month to raise awareness and support advancements in arthritis research. Together, we can take steps toward a pain-free future! 🔥💚✨

#arthritisawarenessmonth #supportarthritis #EULAR #eularadvocacy #osteoarthritis #osteoarthritsawareness #chondrocyteresearch #scienceforchange #research #brigantlab

1 4

The Brigant Lab @brigantlab.bsky.social · May 2

Proud to be part of this new study on uremic toxins & miR-223 in CKD anemia.
🔗Check it:https://doi.org/10.1016/j.ncrna.2025.04.009

#ckd #nephrology #MedSky #AcademicSky #Science #Research #BrigantLab

🚨 Exciting Research Update! 🚨

We’re thrilled to announce the publication of an important and exciting study in Non-Coding RNA Research where BrigantLab was part ! 🎉

We reveal a strong link between uremic toxin levels and the microRNA miR-223 in chronic kidney disease (CKD)-associated anemia. We demonstrated that the uremic toxin indoxyl sulfate (IS) increases miR-223 expression in both human erythroid cell lines and primary cells. In a cohort of over 500 CKD patients, serum miR-223 levels correlated with IS and other uremic toxins, as well as with markers of endothelial dysfunction and anemia severity. 🧬

Why is this important?

These findings position miR-223 as a promising biomarker for monitoring CKD-related anemia and vascular complications—opening the door to more personalized and non-invasive diagnostic strategies. 💡

A huge congratulations to Laurent Metzinger for spearheading this important work, and to all the incredible co-authors: Emma Brisot, Pierre-Marie Leprêtre, Eya Hamza, PhD, MBA, Ophelie Fourdinier, Hakim Ouled-Haddou, Gabriel Choukroun, Ziad Massy, Francis Verbeke, Valérie Metzinger-Le Meuth, and Griet Glorieux! ✨

🔗 Read the full article here: https://doi.org/10.1016/j.ncrna.2025.04.009 [or link in bio]

📖 Stay tuned for more updates from BrigantLab ! 🚀

#ckd #chronickidneydisease #chronickidneydiseaseawareness #anemia #BiomarkerDiscovery #mir223 #uremictoxins #nephrology #Research #Researchpapers #science #lablife #brigantlab

1 2

The Brigant Lab @brigantlab.bsky.social · Apr 25

👋🔬 Behind BrigantLab: Meet co-founder Dr. Benjamin Brigant (NTNU)! 9+ yrs in molecular bio, from France to Norway. Focus: rare genetic conditions, osteoarthritis & more. Cross-country ski lover! ❄️ Follow our science journey! ➡️ [Linktree in bio]
#AcademicSky #MedSky #lablife #BehindBrigantLab

👋🔬 "Behind the BrigantLab" series - Meet the Minds Behind BrigantLab!

Today, let's spotlight Dr. Benjamin Brigant, researcher at NTNU in Trondheim, co-founder and a driving force of BrigantLab ! Currently based at the Norwegian University of Science and Technology (NTNU) in Trondheim, Benjamin brings over 9 years of expertise in molecular and cellular biology to the forefront of our research.

💡 His journey spanned studying studying microRNAs in France (UPJV), pioneering CRISPR-Cas13 RNA targeting in Canada (UoA, Alberta), and exploring CD5L in Norway (NTNU).

Now, at BrigantLab, Benjamin’s work bridges his diverse experiences in inflammation and cartilage biology. His focus includes osteoarthritis, joint disorders, and rare genetic conditions like MULIBREY nanism and Ehlers-Danlos Syndrome, with a special emphasis on joint, cartilage, and inflammation abnormalities. 🧬💪

🌍 His passion for discovery is matched only by his enthusiasm for connecting ideas across disciplines—whether in the lab or at collaborative works.

✨ Fun fact: When he’s not in the lab, you might find him hitting the snow ❄️ and cross-country skiing 🎿 during the winter months!

👉 Follow us for more behind-the-scenes moments, research updates, and a peek into life at BrigantLab!

🦓 Don’t forget, you can support our latest project: https://gofund.me/15cbe96b

🔗 Visit our Linktree in bio to learn more!

#BehindBrigantLab #meettheteam #brigantlab #science #research #supportscience #lablife #skiingscientists

2

The Brigant Lab @brigantlab.bsky.social · Apr 15

Wonder what happens at BrigantLab?🤔
▶️ Exploring the molecular roots of osteoarthritis & genetic diseases like EDS. From lab to clinic, bringing hope! 🧬🔬💫
🔗 Support us via Linktree in bio!

#molecularbiology #osteoarthritis #EDS #AcademicSky #MedSky #lablife #InsideBrigantLab

3

The Brigant Lab @brigantlab.bsky.social · Apr 13

For me (Davina) it took around 15 years. Like you, symptoms had been around since childhood but wasn't heard. Even now, it's a battle to receive appropriate care where I live now, while some symptoms worsen ... Even with more knowledge, it's still complicated...
Thank you for sharing your story🦓🩵💫

1 1

The Brigant Lab @brigantlab.bsky.social · Apr 13

Thank you so much for your support and repost 💫💫💫

1

The Brigant Lab @brigantlab.bsky.social · Apr 4

Thank you. We make the changes. Hope without mistakes 😅

The Brigant Lab @brigantlab.bsky.social · Apr 4

Thank you for being part of the journey. Your support means the world to us. 💫

2

The Brigant Lab @brigantlab.bsky.social · Apr 4

💡 Let’s pave the way of hope together — for better diagnosis, better care, and better futures.

1 3

The Brigant Lab @brigantlab.bsky.social · Apr 4

👉 We just launched our crowdfunding campaign and need YOUR help to make this possible. Whether you can donate, share, or simply spread awareness, you’re already part of this journey.

1 2

The Brigant Lab @brigantlab.bsky.social · Apr 4

🧬 This project is fueled by real stories, real struggles — and the hope that science can bring change.

1 2

The Brigant Lab @brigantlab.bsky.social · Apr 4

For too many, the journey to a diagnosis takes 10+ years, filled with doubt, misdiagnoses, and invisible suffering. We believe people living with EDS deserve better. That’s why our team is working to discover biomarkers that can make diagnosis faster, fairer, and more accurate. 🔬❤️

2 2

The Brigant Lab @brigantlab.bsky.social · Apr 4

Today, we’re proud to launch a research project dedicated to improving the diagnosis of Ehlers-Danlos Syndrome (EDS) — a group of rare and often misunderstood connective tissue disorders that affect millions around the world. 💔

1 2

The Brigant Lab @brigantlab.bsky.social · Apr 4

🌟 After a few weeks of silence, we're thrilled to finally share something close to our hearts — the latest project from Brigant Lab, and it needs your support.

1 2

The Brigant Lab @brigantlab.bsky.social · Apr 4

Help us speed up EDS diagnosis! 🦓 Brigant Lab's biomarker research aims for faster, fairer answers. 💥

🔗 gofund.me/15cbe96b

Your support (donations, shares, kind words) means the world! Thank you! 💖✨
#EDS #ehlersdanlossyndrome #MedSky #Zebras #InsideBrigantLab

Hi everyone!

🌟 After a few weeks of silence, we're thrilled to finally share something close to our hearts — the latest project from Brigant Lab, and it needs your support.

🎉 We’re Launching: “Paving the Way of Hope” 🦓💫

Today, we’re proud to launch a groundbreaking research project dedicated to improving the diagnosis of Ehlers-Danlos Syndrome (EDS) — a group of rare and often misunderstood connective tissue disorders that affect millions around the world. 💔

For too many, the journey to a diagnosis takes 10+ years, filled with doubt, misdiagnoses, and invisible suffering. We believe people living with EDS deserve better. That’s why our team at the Brigant Lab (NTNU, Norway) is working to discover biomarkers that can make diagnosis faster, fairer, and more accurate. 🔬❤️

🧬 This project is fueled by real stories, real struggles — and the hope that science can bring change.

👉 We just launched our crowdfunding campaign and need YOUR help to make this possible. Whether you can donate, share, or simply spread awareness, you’re already part of this journey.

💡 Let’s pave the way of hope together — for better diagnosis, better care, and better futures.

🔗 https://gofund.me/15cbe96b

Thank you for being part of the journey. Your support means the world to us. 🤍

#Pavingthewayofhope#eds#ehlersdanlossyndrome#ehlersdanlossyndromeawareness#chronicillness#invisibledisability#edscommunity#raredisease#zebrastrong #genetics#medicalresearch#crowdfundingscience#supportresearch#supportscience#researchers#lablife #BrigantLab

2 4