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chemsynthbiol.bsky.social
Gavin Williams
@chemsynthbiol.bsky.social
170 followers 150 following 6 posts
Professor and Department Head of Chemistry at NC State. Natural products synthetic biology. Husband. Father. Liverpool Football Club fan.
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chemsynthbiol.bsky.social
Gavin Williams @chemsynthbiol.bsky.social · Apr 18
Excited to share our #polyketide #biosensor artwork featured on the cover of Biochemistry! Thanks to several group members for your help with this! #MyACSCover
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chemsynthbiol.bsky.social
Gavin Williams @chemsynthbiol.bsky.social · Apr 4
pubs.acs.org/doi/full/10....
Engineering the Specificity of Acetyl-CoA Synthetase for Diverse Acyl-CoA Thioester Generation
CoA thioesters are valuable intermediates in numerous biosynthetic routes and metabolic processes. However, diversifying these compounds and their corresponding downstream products hinges on broadenin...
pubs.acs.org
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chemsynthbiol.bsky.social
Gavin Williams @chemsynthbiol.bsky.social · Apr 4
Thrilled to share our latest enzyme engineering in ACS Chemical Biology! We improved an enzyme involved in #polyketide starter unit biosynthesis and used it to generate polyketide acceptor substrates in vitro. Kudos to Jared and the team of authors! @pubs.acs.org
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chemsynthbiol.bsky.social
Gavin Williams @chemsynthbiol.bsky.social · Mar 26
pubs.acs.org/doi/10.1021/...
Promiscuity of an Alcohol-Dependent Hemiterpene Pathway for the In Vivo Production of a Non-Natural Alkylated Tryptophan Derivative
The prenyl motif determines the biological activity of many natural products. Yet, structural diversification of the prenyl site has been restricted due to the limitations of native biosynthetic pathw...
pubs.acs.org
chemsynthbiol.bsky.social
Gavin Williams @chemsynthbiol.bsky.social · Mar 26
Excited to share our @pubs.acs.org Syn Bio publication on the production of non-natural alkylated Trp derivatives in E. coli. Potential applications for #terpene diversification. Kudos to everyone who contributed to this work.
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chemsynthbiol.bsky.social
Gavin Williams @chemsynthbiol.bsky.social · Mar 19
I am thrilled to share our latest biosensor publication in ACS Biochemistry. In this work, we engineered a #biosensor strain for detecting polyketide macrolactones as a step toward applying high-throughput #synbio to polyketide synthases. pubs.acs.org/doi/10.1021/... @ncstatechem.bsky.social
Directed Evolution of a Macrolide-Sensing Transcription Factor Biosensor for the Detection of Macrolactone Aglycones via “Effector Walking” and Efflux Pump Deletion
Glycosylated macrolactones (macrolides) often display broad and potent biological activities and are targets for drug development and discovery. The modular genetic organization of macrolide polyketid...
pubs.acs.org
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