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cmullighan.bsky.social
Charles Mullighan
@cmullighan.bsky.social
210 followers 46 following 4 posts
Haematologist/Haematopathologist ex Adelaide advancing understanding and cures of leukemia at St. Jude Children's Research Hospital.
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cmullighan.bsky.social
Charles Mullighan @cmullighan.bsky.social · Dec 9
Our preprint led by Nicole Michmerhuizen and Emily Heikamp showing the key role and targetability of the MOZ/MORF history acetyltransferases in high-risk NUP98-rearranged acute myeloid leukemia.

www.biorxiv.org/content/10.1...
MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia
NUP98 fusion oncoproteins (FOs) are a hallmark of childhood acute myeloid leukemia (AML) and drive leukemogenesis through liquid-liquid phase separation-mediated nuclear condensate formation. However,...
www.biorxiv.org
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cmullighan.bsky.social
Charles Mullighan @cmullighan.bsky.social · Dec 6
Ilaria Iacobucci presenting work from the lab showing the key role of heme metabolism in erythroleukemia #ASH2024
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cmullighan.bsky.social
Charles Mullighan @cmullighan.bsky.social · Dec 6
#ASH2024
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cmullighan.bsky.social
Charles Mullighan @cmullighan.bsky.social · Nov 20
Glad to share the work of the fantastic Cancer Biomarkers Laboratory of St Jude showing the power and utility of cell free genomic analysis to detect diverse genomic variants in leukemia and many solid tumors. Exciting potential for mutation-specific monitoring. www.nature.com/articles/s41...
Genomic profiling of circulating tumor DNA for childhood cancers - Leukemia
Leukemia - Genomic profiling of circulating tumor DNA for childhood cancers
www.nature.com
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