Although few studies have assessed human exposure to microplastics (MPs) via drinking, almost all have considered human daily fluid intake as composed…

Here, Delaroque et al. show that maternal intake of dietary emulsifiers alters offspring microbiota early in life, which, associated with perturbation of goblet cell function, promotes increased susce...

Rochester General Hospital, the University of Texas Southwestern Medical Center, and Aga Khan University report that applying newer cardiovascular risk equations could sharply reduce the number of mid...

BACKGROUND: The incidence of postural orthostatic tachycardia syndrome (POTS) in long COVID has been a growing concern since the first cases were reported in 2021. The aim of this study was to assess ...

In brief, Santos-Pujol and colleagues characterize the multiomics landscape of the human with the most extreme longevity. The study enables the association of advantageous genetic variants, an engaged...

Lung cancer mortality can be lowered through early-diagnostic screening of people demonstrating a ≥1.5 % 6-year risk of tumor development. However, ma…

YouTube video by Prof. Dr. Christian Rieck

To evaluate the association between chocolate intake and incident clinically apparent atrial fibrillation or flutter (AF).. The Danish Diet, Cancer and Health Study is a large population-based prospec...

Satellites beaming sunlight down to Earth sound like science fiction – and they have astronomers very worried.

Signal Transduction and Targeted Therapy - Oleic acid restores the impaired antitumor immunity of γδ-T cells induced by palmitic acid

Lung cancer mortality can be lowered through early-diagnostic screening of people demonstrating a ≥1.5 % 6-year risk of tumor development. However, ma…

Signal Transduction and Targeted Therapy - Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport

YouTube video by DoktorWeigl

Unwell with a bad throat and temperature? You may have one of the new Covid strains circulating this autumn.

acute-toxicity-and-hypolipidemic-activities-of-clove-and-ginger-extract

In many countries, a large majority of adults consume caffeine daily. This review summarizes the evidence about the varied physiological effects of caffeine and coffee and the risks of cardiovascul...

In brief, Santos-Pujol and colleagues characterize the multiomics landscape of the human with the most extreme longevity. The study enables the association of advantageous genetic variants, an engaged...

BACKGROUND: The incidence of postural orthostatic tachycardia syndrome (POTS) in long COVID has been a growing concern since the first cases were reported in 2021. The aim of this study was to assess ...

Rochester General Hospital, the University of Texas Southwestern Medical Center, and Aga Khan University report that applying newer cardiovascular risk equations could sharply reduce the number of mid...

BackgroundThere is indirect evidence that inhaled traffic-related particulate matter (PM) penetrates into the human circulation. Since nanoparticles readily adhere to red blood cells (RBCs) in vitro, we sought to determine whether a mechanism of systemic transport of translocated traffic-related particles is via adherence to RBCs in vivo.MethodsAdult volunteers were exposed to traffic-related emissions from a main road for 1 h. Volunteers were also exposed to emissions wearing a FFP2 mask. Exposure to black carbon PM was assessed by portable aethalometer. The mean area (μm2) of adherent black PM per RBC was determined from unstained blood smears from 3000 cells by light microscopy. Particle composition was determined by scanning transmission electron microscopy and energy dispersive x-ray analyses. The capacity of diesel exhaust particles (DEP) to adhere to human RBCs in vitro was determined, and RBCs were examined after intratracheal instillation of DEP to a mouse model.ResultsExposure to traffic-related emissions increased personal black carbon PM (n=12, p=0.001 vs. baseline). Exposure increased the area of particles adherent to RBCs (p<0.001 versus baseline), and this was reduced by wearing a FFP2 mask (p=0.002 versus no mask). Traffic exposure increased the abundance of metal-bearing nanoparticles associated with RBCs. Diesel exhaust particles adhered to RBCs in vitro in a dose-dependent manner. Particles were found adherent to circulating RBCs after intratracheal diesel exhaust particles.ConclusionAdhesion of traffic-related PM to RBCs is a systemic transport mechanism. Quantification of particles on RBCs is a putative practical biomarker of inhaled dose.

These findings suggest that IAV infections enhance the systemic propensity for NETosis and foster a procoagulant state, thereby increasing the risk of cerebral damage and thrombosis following stroke. ...

This study assesses the association between cardiorespiratory fitness and long-term mortality in adults undergoing exercise treadmill testing.

Unwell with a bad throat and temperature? You may have one of the new Covid strains circulating this autumn.

YouTube video by Patrick recherchiert