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francirizz.bsky.social
Francesca Rizzollo
@francirizz.bsky.social
950 followers 1K following 6 posts
PhD student at VIB-CCB 👩🏻‍🔬 Cancer biology, cell death, and chasing little organelles 🔬 Food and music lover, professional singer in the shower 🍕
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francirizz.bsky.social
Francesca Rizzollo @francirizz.bsky.social · 25d
Aligned with ferroptosis restricting circulating cancer cells, the BDH2–2,5-DHBA pathway protects mesenchymal cells from ferroptosis in the blood, boosting their capacity to seed secondary organs.
francirizz.bsky.social
Francesca Rizzollo @francirizz.bsky.social · 25d
Restoring BDH2 or supplementing 2,5-DHBA rescues iron transfer, lysosomal pH, and ferroptosis resistance.
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francirizz.bsky.social
Francesca Rizzollo @francirizz.bsky.social · 25d
When BDH2 is lost, iron gets trapped in lysosomes, lysosomal pH rises, and contacts weaken. As a consequence, mesenchymal cells become highly vulnerable to ferroptosis.
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francirizz.bsky.social
Francesca Rizzollo @francirizz.bsky.social · 25d
We show that BDH2 is a key regulator of inter-organelle Fe(II) transfer. In melanocytic cells, BDH2 localizes at mitochondria–lysosome contacts. There it produces the siderophore 2,5-DHBA, which ferries Fe(II) into mitochondria. This supports respiration and lysosomal acidification.
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francirizz.bsky.social
Francesca Rizzollo @francirizz.bsky.social · 25d
Excited to share my PhD paper out now in Nature Metabolism! 🚨 We studied how intracellular iron trafficking controls ferroptosis vulnerability in melanoma. Shout-out to @agostinislab.bsky.social and all collaborators who made this possible! @natmetabolism.nature.com
agostinislab.bsky.social
Agostinis Lab @agostinislab.bsky.social · 25d
Do melanoma cells rewire interorganelle iron flow? ⚡️We found that BDH2 controls lysosome-to-mitochondria Fe2+ transport, coupling lysosomal pH to ferroptosis vulnerability. Huge congrats to @francirizz.bsky.social, thanks to @juliebonnereau.bsky.social and collabs 🙏

www.nature.com/articles/s42...
BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma cell states - Nature Metabolism
Rizzollo et al. show that BDH2 participates in iron distribution between cellular compartments, which sets the threshold for the ferroptosis vulnerability of the melanoma cell phenotypes, ultimately a...
www.nature.com
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Reposted by Francesca Rizzollo
jclandoni.bsky.social
Juan C. Landoni 🔬 @jclandoni.bsky.social · Nov 17
🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! 🚀📜🧪

www.annualreviews.org/content/jour...

#Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA
Review title Review sections graphic Sub compartments of mitochondria graphic Mitochondrial.dynamics graphic
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Reposted by Francesca Rizzollo
nicola-fattorelli.bsky.social
Nicola Fattorelli @nicola-fattorelli.bsky.social · Nov 16
Hi Bluesky 🦋 I’m Nico, a microglia enthusiast based in VIB, Belgium 🧠 if you are curious about the science we do, take a look at our latest work! Here we use xenotransplantation models to map the spectrum of human microglia responses to Alzheimer’s disease pathology www.nature.com/articles/s41...
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology - Nature Neuroscience
Human microglia transplanted in the mouse brain mount a multipronged response to amyloid-β pathology, displaying unique transcriptional states. Alzheimer’s disease risk genes are differentially regula...
www.nature.com
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Reposted by Francesca Rizzollo
wmeira.bsky.social
Willian Meira @wmeira.bsky.social · Nov 17
#StartPack for the #Ferroptosis researchers community.

A small but growing list—let’s expand it together!

Please, feel free to reach out if you'd like to be added or removed. 🧪🔬

go.bsky.app/35UvtTi
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Reposted by Francesca Rizzollo
ivanoamelio.bsky.social
Ivano Amelio @ivanoamelio.bsky.social · Nov 16
Let's bring the #CellDeath community together here on 🦋

Just get in touch to join this Starter Pack

go.bsky.app/R6mGrKU
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francirizz.bsky.social
Francesca Rizzollo @francirizz.bsky.social · Nov 15
Hi Bluesky community 👋🏻🦋 just moved in! I’m a PhD student @ VIB (Belgium), interested in iron metabolism, membrane contact sites, ferroptosis, and cancer biology. If this sounds like something for you, take a look at our latest preprint 👉 www.researchsquare.com/article/rs-5...
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