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Which formulation of HRT would you recommend?

Prof G @gavingiovannoni.bsky.social · 6d

#MS_Selfie: Which formulation of HRT would you recommend?

"It is encouraging to see these large-scale reconsiderations of the beneficial effects of HRT. However, it is upsetting that a generation of women missed out on the process.” => buff.ly/XI08YEN

"It is encouraging to see these large-scale reconsiderations of the beneficial effects of HRT. However, it is upsetting that a generation of women missed out on the process.”

Q&A 118: ECTRIMS 2025 & CAR T-cells

Prof G @gavingiovannoni.bsky.social · 9d

#MS_Selfie Q&A 118: ECTRIMS 2025 & CAR T-cells

I believe this is one of the most promising therapeutic strategies being tested in MS for several reasons: its CNS and deep tissue penetration, as well as its anti-EBV properties. => buff.ly/dE1kODU

I believe this is one of the most promising therapeutic strategies being tested in MS for several reasons: its CNS and deep tissue penetration, as well as its anti-EBV properties.

Q&A 117: ECTRIMS 2025 - EBV & MS

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Prof G @gavingiovannoni.bsky.social · 9d

If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis? gavingiovannoni.substack.com/p/q-and-a-11...

If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis?

Q&A 117: ECTRIMS 2025 - EBV & MS

Prof G @gavingiovannoni.bsky.social · 9d

#MS_Selfie Q&A 117: ECTRIMS 2025 - EBV & MS

If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis? => buff.ly/h5QHqgM

If EBV is necessary for the development of MS, why wouldn't we consider including EBV serology as part of the MS diagnosis?

ECTRIMS 2025: blowing my own horn

Prof G @gavingiovannoni.bsky.social · 12d

#MS_Selfie ECTRIMS 2025: blowing my own horn

The highlight of the meeting was my presentation of the ocrelizumab results in the PPMS O’HAND study, which were positive. buff.ly/EWHOuBw

The highlight of the meeting was my presentation of the ocrelizumab results in the PPMS O’HAND study, which were positive.

Q&A 116: which antiviral?

Prof G @gavingiovannoni.bsky.social · 23d

#MS_Selfie Q&A 116: Which antiviral?

There is a fine line between being an innovator and a quack. The observational data strongly support moving forward with EBV antiviral strategies in MS .... buff.ly/8CaFvBv

There is a fine line between being an innovator and a quack. The observational data strongly support moving forward with EBV antiviral strategies in MS ....

Prof G @gavingiovannoni.bsky.social · 24d

What a journey for people with MS and their HCPs. Natalizumab has taught us a great deal about MS. We try to tell the story in this review paper => buff.ly/WWjC7Ql

Prof G's response to the AI-generated newsletter

Prof G @gavingiovannoni.bsky.social · 25d

One of Gemini’s scotomas (blind spots) was the lack of mention of a systemic or local toxin driving MS pathology. gavingiovannoni.substack.com/p/prof-gs-re...

One of Gemini’s scotomas (blind spots) was the lack of mention of a systemic or local toxin driving MS pathology.

Prof G's response to the AI-generated newsletter

Prof G @gavingiovannoni.bsky.social · 25d

#MS_Selfie - Prof G's response to the AI-generated newsletter

One of Gemini’s scotomas (blind spots) was the lack of mention of a systemic or local toxin driving MS pathology.

Anxiety and uncertainty are not good bedfellows when considering treatment options for multiple sclerosis.

Prof G @gavingiovannoni.bsky.social · 26d

#MS_Selfie Q&A 115: AHSCT or not?

Anxiety and uncertainty are not good bedfellows when considering treatment options for multiple sclerosis. Should this young woman have the option of AHSCT? => buff.ly/e7bwckp

Q&A 115: AHSCT or not?

How useful is AI-generated content in the field of MS?

Prof G @gavingiovannoni.bsky.social · 28d

#MS_Selfie: How useful is AI-generated content in the field of MS?

I have been having a back-and-forth argument with colleagues about the value of AI in MS research. I therefore asked Google Gemini Pro 2.5 Deep Research the following question: ... -> buff.ly/v3ot0m6

I have been having a back-and-forth argument with colleagues about the value of AI in MS research. I therefore asked Google Gemini Pro 2.5 Deep Research the following question:

Q&A 114: Muscle loss and sarcopenia on GLP-1 receptor agonists

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Prof G @gavingiovannoni.bsky.social · Sep 12

#MS_Selfie Q&A 114: Muscle loss and sarcopenia on GLP-1 receptor agonists

If you have been prescribed a GLP-1 RA, did your HCP assess your muscle function at baseline and provide you with information about how to prevent muscle loss? Are you having regular assessments? => buff.ly/qn6S9wI

If you have been prescribed a GLP-1 RA, did your HCP assess your muscle function at baseline and provide you with information about how to prevent muscle loss? Are you having regular assessments?

Q&A 113: Should I take creatine supplements?

Prof G @gavingiovannoni.bsky.social · Sep 11

#MS_Selfie Q&A 113: Should I take creatine supplements?

If you have started taking creatine, have you noted any impact on your MS symptoms, level of functioning and quality of life? => buff.ly/LumDjFy

If you have started taking creatine, have you noted any impact on your MS symptoms, level of functioning and quality of life?

Burnout RX: HCP's silent struggle

Prof G @gavingiovannoni.bsky.social · Sep 11

Burnout RX: HCP's silent struggle impact.economist.com/health/healt...

Burnout RX—the hidden social and economic costs of a silent crisis among healthcare professionals

impact.economist.com

Prof G @gavingiovannoni.bsky.social · Sep 10

#MS_Selfie - Energy drinks vs. Coffee

Are you self-medicating MS-related symptoms using energy drinks or coffee? => buff.ly/2CGG9Za

Energy drinks vs. Coffee

Are you self-medicating MS-related symptoms using energy drinks or coffee?

If you are going to go ahead with cladribine, I recommend TB prophylaxis, but this needs to be done via a TB clinic. I would not recommend INH alone, but the two-drug combination.

Prof G @gavingiovannoni.bsky.social · Sep 9

If you are going to go ahead with cladribine, I recommend TB prophylaxis, but this needs to be done via a TB clinic. I would not recommend INH alone, but the two-drug combination.

GAVIN GIOVANNONI gavingiovannoni.substack.com/p/q-and-a-11...

Q&A 112: Latent TB

If you are going to go ahead with cladribine, I recommend TB prophylaxis, but this needs to be done via a TB clinic. I would not recommend INH alone, but the two-drug combination.

Prof G @gavingiovannoni.bsky.social · Sep 9

#MS_Selfie Q&A 112: Latent TB

Q&A 112: Latent TB

Q&A 111: Glucagon-like peptide-1 receptor agonists (GLP-1RAs)

Prof G @gavingiovannoni.bsky.social · Sep 4

#MS_Seflie Q&A 111 (a Nelson): Glucagon-like peptide-1 receptor agonists (GLP-1RAs)

Should I start tirzepatide or semaglutide to treat my MS? => buff.ly/OueDpzp

Should I start tirzepatide or semaglutide to treat my MS?

DR KRISTEN KRYSKO WINS 2025 RACHEL HORNE PRIZE FOR WOMEN’S RESEARCH IN MULTIPLE SCLEROSIS

Prof G @gavingiovannoni.bsky.social · Sep 3

Women's Health & Research MS is finally getting the recognition it deserves. gavingiovannoni.substack.com/p/dr-kristen...

Women's Health & Research MS is finally getting the recognition it deserves.

Women's Health & Research MS is finally getting the recognition it deserves.

Prof G @gavingiovannoni.bsky.social · Sep 3

DR KRISTEN KRYSKO WINS 2025 RACHEL HORNE PRIZE FOR WOMEN’S RESEARCH IN MULTIPLE SCLEROSIS

If you have a significant problem with anxiety and/or depression, please discuss this with your HCP. Simply living with anxiety and depression as a ‘new normal’ is not a solution.

Prof G @gavingiovannoni.bsky.social · Sep 2

#MS_Selfie Q&A 110: Anxiety and MS

If you have a significant problem with anxiety and/or depression, please discuss this with your HCP. Simply living with anxiety and depression as a ‘new normal’ is not a solution. buff.ly/3VAmZVZ

Q&A 110: Anxiety and MS

Q&A 109: Antivirals as treatment for MS

Prof G @gavingiovannoni.bsky.social · Sep 1

I would be interested to hear how many of you have started taking antivirals as a potential treatment for your MS; if so, who prescribed the antivirals? gavingiovannoni.substack.com/p/q-and-a-10...

I would be interested to hear how many of you have started taking antivirals as a potential treatment for your MS; if so, who prescribed the antivirals?

Q&A 109: Antivirals as treatment for MS

Prof G @gavingiovannoni.bsky.social · Sep 1

#MS_Selfie Q&A 109: Antivirals as treatment for MS

I would be interested to hear how many of you have started taking antivirals as a potential treatment for your MS; if so, who prescribed the antivirals? buff.ly/N88fBfB

I would be interested to hear how many of you have started taking antivirals as a potential treatment for your MS; if so, who prescribed the antivirals?

Q&A 108: Dairy Sensitivity and MS

Prof G @gavingiovannoni.bsky.social · Aug 29

I apologise for the delay in responding to your question. It has taken me some time to review the relevant literature. I hope this newsletter helps. gavingiovannoni.substack.com/p/q-and-a-10...

I apologise for the delay in responding to your question. It has taken me some time to review the relevant literature. I hope this newsletter helps.