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havardtl.bsky.social
Håvard Lindholm
@havardtl.bsky.social
37 followers 98 following 2 posts
Bioinformatics, transposable elements, immunology and more! Department of Pathology, Oslo University Hospital
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Reposted by Håvard Lindholm
daniel-decarvalho.bsky.social
Daniel De Carvalho @daniel-decarvalho.bsky.social · 16d
Excited to have this paper out today!

Repeats mimic pathogen-associated patterns across a vast evolutionary landscape."

It was a fun and productive collaboration with Benjamin Greenbaum John LaCava, Simona Cocco, Petr Šulc and many others!

www.cell.com/cell-genomic...
Repeats mimic pathogen-associated patterns across a vast evolutionary landscape
An emerging hallmark of disease is transcription of pathogen-associated molecular patterns from within the genome–known as viral mimicry. We propose a statistical physics framework to measure “selecti...
www.cell.com
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havardtl.bsky.social
Håvard Lindholm @havardtl.bsky.social · 17d
Nice to see this story out! The idea that viral mimicry is an intrinsic feedback mechanism for sensing cellular dysregulation is fascinating and this paper explores this idea really well.

It was inspiring to be part of this collaborative work. Thanks to @bengrbm.bsky.social and the rest!
Repeats mimic pathogen-associated patterns across a vast evolutionary landscape
An emerging hallmark of disease is transcription of pathogen-associated molecular patterns from within the genome–known as viral mimicry. We propose a statistical physics framework to measure “selecti...
www.cell.com
1 4
havardtl.bsky.social
Håvard Lindholm @havardtl.bsky.social · 22d
😂
Reposted by Håvard Lindholm
uhnresearch.ca
Research at UHN @uhnresearch.ca · Apr 11
Congratulations to Dr. Daniel De Carvalho (@daniel-decarvalho.bsky.social) on winning the 2025 Gairdner Momentum Award! 🎉

His impactful work in cancer epigenetics is revolutionizing early detection and treatment. A well-deserved honour! 👏

🔗 www.uhnresearch.ca/news/gairdne...
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Reposted by Håvard Lindholm
daniel-decarvalho.bsky.social
Daniel De Carvalho @daniel-decarvalho.bsky.social · Jan 17
Our recent work on Viral mimicry escape in Ovarian Cancer is out at Cancer Discovery: aacrjournals.org/cancerdiscov...
Chronic viral mimicry induction following p53 loss promotes immune evasion
Abstract. Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through ‘viral mimicry’ responses. Paradoxically, cancer-initiating events also facili...
aacrjournals.org
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