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Jeronimo Lukin

@jer0luk.bsky.social

170 followers 590 following 3 posts

🇦🇷⚽🏆 🐞| Neuroscience 🧠 | Postdoc at @DeRubeisLab, Mount Sinai.

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Jeronimo Lukin @jer0luk.bsky.social · May 20

New paper from our lab!

Happy to contribute to this collective effort, advancing our understanding of DDX3X and its role in #DDX3Xsyndrome

Silvia De Rubeis @derubeislab.bsky.social · May 18

🧪 New paper alert!

In new work led by Adele Mossa out now in @natcomms.nature.com, we find that the #autism risk gene #DDX3X is a critical regulator of sexual dimorphisms in neuronal neurodevelopment 🧬 🧠

www.nature.com/articles/s41...

Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X - Nature Communications

Genetic mutations in the DDX3X gene are associated with a neurodevelopmental disorder primarily affecting females. Here authors show that Ddx3x mediates sexual dimorphisms during brain development at ...

www.nature.com

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Reposted by Jeronimo Lukin

Biology Open @biologyopen.bsky.social · Mar 24

#DDX3X syndrome is a rare neurodevelopmental disorder affecting motor & cognitive functions. Using a mouse model of DDX3X 🐭 , Michael Flores & co investigate how the development and circuit organization of a layer five neuronal subpopulation in the cortex is disrupted. doi.org/10.1242/bio....

Cortico-brainstem neurons of Ddx3x mutant female mice have altered laminar position and expression of CTIP2 and BRN1. (A) Retrograde tracing of cortico-brainstem neurons reaching the pons. Subpanel a, schematics of the coronal plane corresponding to the site of injection of rAVV-CAG-GFP (pontine reticular nucleus, PNRr), including a sagittal view. Subpanel b, coronal section of a brain 3 weeks after the stereotaxic surgery, showing the ipsilateral labeling of neurons extending axons from the MOp and SSp to the brainstem. Subpanel c, sagittal section of a brain 3 weeks after the stereotaxic surgery, as in subpanels a and b.

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Jeronimo Lukin @jer0luk.bsky.social · Feb 21

Huge thanks to the incredible co-authors for their collaboration. Great multidisciplinary team!
@msbeckel @OPedroncini @SebasGiusti @Ivanaml_ @inespatop.bsky.social @achernom.bsky.social @amarinburgin.bsky.social @skadener.bsky.social @IBioBA_MPSP

Jeronimo Lukin @jer0luk.bsky.social · Feb 21

😊🔬 Happy to share our preprint manuscript from my PhD! This study sheds light on stimuli specific activity-dependent gene expression and its changes during neuronal development in vitro. Looking forward to discussions and new perspectives!

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Feb 21

Neuronal development shapes activity-dependent gene expression in a stimulus-specific manner https://www.biorxiv.org/content/10.1101/2025.02.19.638694v1

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Reposted by Jeronimo Lukin

Artemis Iatrou @artemiat.bsky.social · Dec 9

#ACNP2024
@nikosdaskalakis.bsky.social introduced part of my work during his talk. Stop by my poster T130 tomorrow Tuesday 5-7pm for a chat and more insights. 🧠🫧

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