Merci beaucoup à la @sfvirologie.bsky.social pour ce prix et pour ces journées riches en belle science ❤️🦠
Vivement l'année prochaine à Toulouse

En direct des #JFV2025!
@sfvirologie.bsky.social

Our latest collaborative study with the Pasteur Institute and University of Toronto on the role of RANBP2 in #influenza -associated hyperinflammation #AcuteNecrotizingEncephalopathy @aneinternational.bsky.social @ribonucleicacids.bsky.social @irim-life.bsky.social
www.biorxiv.org/content/10.1...

Congratulations! Such a nice study. What a year for the team 🎉

Thank you, Juan! I'm glad you enjoyed the read. I believe this small protein still has many secrets to reveal

Thanks for everyone involved in this study, and especially my great superviser who allowed all of this to happen @sebnisole.bsky.social ! 🎊

@irim-life.bsky.social

𝗪𝗵𝗲𝗿𝗲 𝗶𝘀 𝗠𝗜𝗧𝗗𝟭 𝗶𝗻𝗱𝘂𝗰𝗲𝗱 𝗯𝘆 𝗶𝗻𝘁𝗲𝗿𝗳𝗲𝗿𝗼𝗻?

🧠 Mouse data pointed to the 𝗯𝗿𝗮𝗶𝗻, so we tested human brain cells. Only microglia, the immune sentinels of the brain, showed interferon-driven MITD1 expression.

🚨 This makes 𝗠𝗜𝗧𝗗𝟭 𝗮 𝗺𝗶𝗰𝗿𝗼𝗴𝗹𝗶𝗮-𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰 𝗜𝗦𝗚, protecting the brain from flaviviruses

𝗛𝗼𝘄 𝗱𝗼𝗲𝘀 𝗠𝗜𝗧𝗗𝟭 𝗯𝗹𝗼𝗰𝗸 𝘃𝗶𝗿𝗮𝗹 𝗿𝗲𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻?

🧬 MITD1 overexpression forms cytoplasmic aggregates that deplete CHMP1B+4B, key ESCRT-III proteins.

🔬 PLA confirmed their recruitment to flavivirus replication factories. Knockdown of CHMP1B+4B hinders MITD1’s antiviral effect—proving a link

To uncover new host factors restricting flavivirus replication, we screened a library of >1,000 interferon-stimulated genes (ISGs) across multiple species.

Among known antiviral ISGs, we found 𝗠𝗜𝗧𝗗𝟭, a never-described-as-antiviral-before factor, as a potent inhibitor of WNV, USUV, ZIKV & DENV

🚨 New study in @pnas.org ! 🚨

We identified MITD1, a brain-specific interferon-inducible factor that 𝗶𝗻𝗵𝗶𝗯𝗶𝘁𝘀 𝗳𝗹𝗮𝘃𝗶𝘃𝗶𝗿𝘂𝘀 𝗿𝗲𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻, including WNV, USUV, ZIKV & DENV.

🔗 Read the paper: www.pnas.org/doi/10.1073/...
👇 Thread with take-home messages below!

#Virology #Flavivirus #Interferon

Check our latest opinion piece, just out in @cp-trendsmicrobiol.bsky.social! We delve into how the antiviral RNase ISG20 targets viral RNA and how some viruses escape it.
@irim-life.bsky.social @ciri-lyon.bsky.social

www.cell.com/trends/micro...