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kirolloskamel.bsky.social @kirolloskamel.bsky.social · Sep 1

🚨FDA approves rilzabrutinib – 1st BTK inhibitor for ITP

LUNA3: heavily pre-treated pts (median 4 prior lines, 28% splenectomy), durable PLT response 23% vs 0% PBO; 64% initial rise; median 15d. ↓ rescue Rx, ↓ bleeding, ↑ QoL. Well-tolerated

Australia needs this! 🇦🇺
@thanzblood.bsky.social #hemesky

kirolloskamel.bsky.social @kirolloskamel.bsky.social · Sep 1

Results of HIPRO single centre RCT out In pts w/ provoked VTE + enduring risk (obesity, chronic inflammation, CVD, lung dz), 12 mo low-dose apixaban cut recurrence 1.3% vs 10% (HR 0.13, NNT≈12). Major bleed rare; CRNM bleed ↑ (NNH≈32). Subgroup analysis underpowered.

www.nejm.org/doi/full/10....

Apixaban for Extended Treatment of Provoked Venous Thromboembolism | NEJM

The appropriate duration of anticoagulation for venous thromboembolism (VTE) in patients who have a transient provoking factor (e.g., surgery, trauma, or immobility) and concomitant enduring risk f...

www.nejm.org

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kirolloskamel.bsky.social @kirolloskamel.bsky.social · Aug 2

t(8;14) IGH-MYC. Rarely 2;8 or 8;22

kirolloskamel.bsky.social @kirolloskamel.bsky.social · Aug 1

Poll question for haematologists

Is there still a role for Activated Protein C Resistance testing in the assessment for thrombophilia, when FVL PCR is readily available?

1️⃣ YES
2️⃣ NO

Reply with number below.

#hemesky

kirolloskamel.bsky.social @kirolloskamel.bsky.social · Jul 19

Splenic marginal zone lymphoma

kirolloskamel.bsky.social @kirolloskamel.bsky.social · Jul 6

www.sciencedirect.com/science/arti...

I came across this “practical guideline” for major heritable thrombophilia. I am not sure I agree with some of their recommendations - should generate an interesting debate though. Also have never tested for the F2 AT resistance mutations!

#hemesky

Practical guideline for major hereditary thrombophilia

www.sciencedirect.com

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kirolloskamel.bsky.social @kirolloskamel.bsky.social · Jul 6

Plasmodium falciparurm

kirolloskamel.bsky.social @kirolloskamel.bsky.social · Jun 26

Combined HbC trait and G6PD deficiency!

Blood Journals' Portfolio @bloodjournals.hematology.org · Jun 25

A previously healthy 7-year-old African American boy was admitted for anemia and hemoglobinuria. buff.ly/WDXkNJT #hemesky #BloodWork

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kirolloskamel.bsky.social @kirolloskamel.bsky.social · Jun 23

Biology resists simplicity #ISTH2025 plenary session

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kirolloskamel.bsky.social @kirolloskamel.bsky.social · Jun 23

Personal highlights from day 2 of #ISTH2025 👇

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kirolloskamel.bsky.social @kirolloskamel.bsky.social · Jun 23

Personal highlights from day 1 of #ISTH2025 👇

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kirolloskamel.bsky.social @kirolloskamel.bsky.social · Jun 14

Babesiosis - the insert shows a Maltese Cross

kirolloskamel.bsky.social @kirolloskamel.bsky.social · May 31

Giant pronormoblasts seen in parvovirus B19

kirolloskamel.bsky.social @kirolloskamel.bsky.social · May 4

I think this drug will settle many an argument ….

jamanetwork.com/journals/jam...

Prothrombin Complex Concentrate vs Frozen Plasma in Cardiac Surgery

This clinical trial compares the efficacy and safety of prothrombin complex concentrate with frozen plasma in patients requiring coagulation factor replacement for bleeding during cardiac surgery.

jamanetwork.com

kirolloskamel.bsky.social @kirolloskamel.bsky.social · May 4

Fascinating paper; which reinforces my own clinical experience that the majority of clinically encountered type I protein S deficiency behave like a low risk thrombophilia, presumably as they have the missense variant. We need more studies like this!

jamanetwork.com/journals/jam...

Population-Scale Studies of Protein S Abnormalities and Thrombosis

This cross-sectional study evaluates the risk associated with protein S deficiency across multiple arterial thrombosis phenotypes in population-level cohorts.

jamanetwork.com

kirolloskamel.bsky.social @kirolloskamel.bsky.social · Apr 11

Delighted to present our survey results on the management of superficial thrombophlebitis in the short saphenous vein when in close proximity to the saphenopopliteal junction at ISTH congress June 21-25, 2025.

If you’re there, come and check out our poster.

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kirolloskamel.bsky.social @kirolloskamel.bsky.social · Apr 11

@isth.org #Hemesky

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Reposted

Displaycia Journals @displaycia.bsky.social · Apr 10

📢 Hematology Breakthrough! 🧑‍⚕️🔬

📌 Follow us for more updates: @displaycia.bsky.social

🔗 Read more: displaycia.com/medic...

#Hematology #HealthScience #Breakthrough #MedicalScience #ManuscriptSubmission #ScientificResearch #Innovation #Displaycia

Hematology Breakthrough | Displaycia | Global Journal of Medical and Health Sciences Research (GJMHSR)

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kirolloskamel.bsky.social @kirolloskamel.bsky.social · Apr 7

Bottom line - the LLN for Ferritin in both women and men should be at least 30 in the absence of inflammation and chronic kidney disease.

American Society of Hematology @ash.hematology.org · Apr 5

Non-anemic iron deficiency (NAID) and iron deficiency anemia (IDA) affect millions of women, yet many are often underdiagnosed and undertreated.

Why? Structural barriers, inconsistent diagnostic thresholds, and lack of awareness.

Learn more: https://bit.ly/4c901LU

#Hematology #HemeSky

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kirolloskamel.bsky.social @kirolloskamel.bsky.social · Apr 2

Interstitial infiltration with monomorphic medium mature lymphocytes. Starry sky appearance would favour Burkitt but is not specific.

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Reposted

Raza @transfusion.health · Mar 31

FARES-II: Much anticipated randomized trial @jama.com comparing Plasma to PCC in cardiac surgery (n=420)

Those in PCC arm had ↑ hemostatic efficacy and ↓ RBC transfusion

Hopefully practice-changing for many!

jamanetwork.com/journals/jam...

#transfusion #hemesky

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kirolloskamel.bsky.social @kirolloskamel.bsky.social · Mar 30

@nejm.org

kirolloskamel.bsky.social @kirolloskamel.bsky.social · Mar 30

Finally! More data to add to the EVE trial

APICAT showed non inferiority of apixaban 2.5BD in patients with CAVTE who have completed 6m anticoagulation to 5BD in terms of VTE recurrence (2.1% v 2.8%) and lower clinically relevant bleeding (12.1% v 15.6%)

#Hemesky #BSH

www.nejm.org/doi/full/10....

Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism | NEJM

In patients with active cancer and venous thromboembolism, whether extended treatment with a reduced dose of an oral anticoagulant is effective in preventing recurrent thromboembolic events and dec...

www.nejm.org

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kirolloskamel.bsky.social @kirolloskamel.bsky.social · Mar 30

doi.org/10.1182/hem....

This is a fantastic read. Strongly recommended. #Hemesky

A Hematopathologist’s Approach to Atypical Lymphocytosis

A 23-year-old presented to the emergency room with a headache and a fever of 101.5 degrees Fahrenheit. Physical examination revealed a fatigued patient wit

doi.org

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kirolloskamel.bsky.social @kirolloskamel.bsky.social · Mar 29

Spherocytes lacking central pallor. Differential diagnosis warm autoimmune haemolytic anaemia, haemolytic transfusion reactions and hereditary spherocytosis