people seem to talk about 3 factors.

1. dynamics of GAL4 itself, life cycle / lifespan changes with temp
2. thermodynamics of the GAL4
3. A few cite HS promoters on the UAS side.

There could be other contributors

Figure 4 supplement 1 shows the effect on protein

elifesciences.org/articles/053...

Congrats Danielle!!!

Excess Wnt in neurological disease url:https://portlandpress.com/biochemj/article/482/10/BCJ20240265/236054/Excess-Wnt-in-neurological-disease

Over 1300 signatures and climbing.

docs.google.com/document/d/1...

It is so amazing to see that over 800 people so far have signed on to this open letter from Canadian researchers to the federal party leaders! So many incredible people who do such amazing research docs.google.com/document/d/1...

Dear Canadian researchers, faculty, RAs, PDFs and grad students, this letter is for the federal party leaders asking them to defend and expand Canadian research sovereignty with a historic investment in science, please sign and share
docs.google.com/document/d/1...

Congrats!!!!

Canada should double the entire research budget for base level funding (project, discovery, insight) and trainee fellowships. @markcarney2025.bsky.social if you win today - research needs to be part of the platform. The economics work. Research investments pay for themselves (and then some).