Mike Lee
@theleelab.bsky.social
A laboratory of Systems Pharmacology at UMass Medical School. We study cancer therapies, and aim to understand how they activate cell death and how to make this work better.
https://www.umassmed.edu/Lee-Lab
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Mike Lee
@theleelab.bsky.social
· Aug 15
RNA Pol II inhibition activates cell death independently from the loss of transcription
When RNA polymerase II (RNA Pol II) is inhibited, the inhibition is sensed and signaled
to mitochondria, leading to programmed cell death independently of the loss of RNA
Pol II transcription activity...
www.cell.com
I’m excited to highlight our latest paper, just published in Cell 🎉
We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.
1/n 🧪
www.cell.com/cell/fulltex...
We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.
1/n 🧪
www.cell.com/cell/fulltex...