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Stephen Oh

@mpndoc.bsky.social

460 followers 160 following 31 posts

Physician-scientist interrogating inflammatory cytokine-signaling networks in myeloproliferative neoplasms. #mpnsm. Co-Chief, Division of Hematology, Washington University School of Medicine. ohlab.org

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Stephen Oh @mpndoc.bsky.social · Jan 17

Delighted to share our latest study now online @naturecomms.bsky.social! Thanks to 1st author Tim Kong + multiple Oh Lab members & collaborators for their contributions! #hemesky @washumedicine.bsky.social @sitemancenter.bsky.social
medicine.washu.edu/news/drug-in...
www.nature.com/articles/s41...

Drug in clinical trials for breast cancer could also treat some blood cancers | WashU Medicine

Researchers are working with industry toward a clinical trial for blood cancer patients

medicine.washu.edu

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Stephen Oh @mpndoc.bsky.social · Jun 18

Congrats to all awardees + special shoutout to my dear friend, collaborator & sage adviser Jorge Di Paola truly deserving of the ASH Mentor Award! 🥳🙌👏 @washumedicine.bsky.social

American Society of Hematology @ash.hematology.org · Jun 18

ASH is proud to recognize 11 hematologists whose groundbreaking research and leadership have transformed the understanding and care of blood disorders. Congratulations to all! 👏

🔗 https://bit.ly/3G14rIW

#HemeSky #ASHAwards

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Stephen Oh @mpndoc.bsky.social · May 6

Proud to roll with this crew! 🤩 Celebrating our graduating students Varun, Lowell, and Tim! 🥳

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Stephen Oh @mpndoc.bsky.social · Apr 27

Congrats Katherine! 🎉

Stephen Oh @mpndoc.bsky.social · Jan 17

We further unveil a novel therapeutic approach utilizing a first-in-class RSK inhibitor, PMD-026, that suppressed disease burden across syngeneic and PDX leukemia mouse models spanning the spectrum of driver and disease-modifying mutations.

Stephen Oh @mpndoc.bsky.social · Jan 17

Combining ATAC-Seq, CUT&Tag, RNA-seq, and CyTOF, we demonstrate that targeting of RSK1 suppresses NFκB activation and diminishes pro-inflammatory mediators including TNF associated with MPN disease severity and transformation.

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Stephen Oh @mpndoc.bsky.social · Jan 17

Here we establish a comprehensive atlas across MPNs and secondary AML including RNA-sequencing of 158 primary samples encompassing CD34+ HPSCs and CD14+ monocytes. Supported by mass cytometry (CyTOF) profiling, we reveal aberrant PI3K/AKT/mTOR signaling and NFκB-mediated hyper-inflammation.

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Stephen Oh @mpndoc.bsky.social · Jan 17

Drug in clinical trials for breast cancer could also treat some blood cancers | WashU Medicine

Researchers are working with industry toward a clinical trial for blood cancer patients

medicine.washu.edu

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Stephen Oh @mpndoc.bsky.social · Jan 12

Postdoc candidates check out this exciting opportunity! 🤩 #HemeSky

Yoona Kang @ykanglab.bsky.social · Jan 12

We are hiring 😀

Postdoctoral position – Stem cells, Cancer, and Aging

We study cell fate decision and lineage specification in hematopoietic stem and multipotent progenitor populations to modulate lineage output for therapeutic purpose in diseases and aging contexts.

Stephen Oh @mpndoc.bsky.social · Dec 15

🎉 Happy Holidays from #OhLab #TeamMPN! 🎉 #familypic #holidayparty #BooCatClub #speakeasyafterparty

Stephen Oh @mpndoc.bsky.social · Dec 8

Was too busy with 🥳🍷🎉to take many pics but had so much fun at our WashU Hematology reception Friday evening especially co-hosting with great friend and collaborator Jorge Di Paola! #ASH24 @ash-hematology.bsky.social

Stephen Oh @mpndoc.bsky.social · Dec 7

Nice back 2 back talks & worlds colliding with new WashU faculty Helen Ajufo presenting her studies wifh Raajit Rampal and Jeff Zwicker + former WashU IM resident Joan How presenting GASTRO-MPN a collaborative effort including our faculty Kristen Sanfilippo! #ASH24 @ash-hematology.bsky.social

Stephen Oh @mpndoc.bsky.social · Dec 7

🤩 Wow wow wow #ASH24 attendees have 2x opportunities today to catch Molly Brakhane presenting her work today!

🏃🏃‍♀️🏃‍♂️Jog/run/sprint (don’t walk) to the poster walk at 11:15am featuring Molly’s poster.

And come to the poster session this evening (#1169)! 😁

@ash-hematology.bsky.social

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Stephen Oh @mpndoc.bsky.social · Dec 6

Excited for this workshop this afternoon and grateful to the organizers Christina Glytsou, Panos Ntziachristos, & Dan Starczynowski for the opportunity to speak in the session alongside @gritsmanlab.bsky.social & Marek Mraz! #ASH24 #hemesky @ash-hematology.bsky.social
ash.confex.com/ash/2024/web...

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Stephen Oh @mpndoc.bsky.social · Dec 5

Ready to board the WashU bus to #ASH24! @ash-hematology.bsky.social #hemesky

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Stephen Oh @mpndoc.bsky.social · Dec 5

And check out my talk on Friday afternoon at the Scientific Workshop on Therapy Resistance Mechanisms in Blood Malignancies where I will be highlighting work from superstar MSTP student Tim Kong!
ash.confex.com/ash/2024/web...

Paper: Aberrant DUSP6-RSK1 Signaling Axis Mediates Treatment Resistance and Disease Progression in Myeloproliferative Neoplasms

ash.confex.com

Stephen Oh @mpndoc.bsky.social · Dec 5

Come to Fan's oral presentation during the MPN session on Monday afternoon!
ash.confex.com/ash/2024/web...

Paper: Monocyte-Driven Aberrant Inflammation in Myeloproliferative Neoplasms Is Regulated By Galectin-1

ash.confex.com

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Stephen Oh @mpndoc.bsky.social · Dec 5

Check out Molly's presentation during the poster walk on Saturday morning & at the evening poster session!
ash.confex.com/ash/2024/web...
ash.confex.com/ash/2024/web...

Paper: Altered Calcium Signaling Via STIM1 Drives Aberrant Megakaryopoiesis and Myelofibrosis

ash.confex.com

Stephen Oh @mpndoc.bsky.social · Dec 5

Super proud of Oh Lab members Molly Brakhane & Fan He presenting at #ASH24! 🤩

Both are recipients of @ash-hematology.bsky.social abstract achievement awards! 🥳

#mpnsm #ASHkudos

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Reposted by Stephen Oh

Kellie Machlus @kmachlus.bsky.social · Dec 5

Everyone headed to #ASH24 - if you’re looking for your favorite scientists in hematopoiesis to follow on here, we have you covered 👇🏼

Kellie Machlus @kmachlus.bsky.social · Nov 17

Finally- the starter pack we have all been waiting for is here … Hematopoiesis 🎉❤️🩸🦴

So excited to have reached a critical mass of this community on here. 🙌🏻
Let me know if you want to be added!!

go.bsky.app/KWdX5w7

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Stephen Oh @mpndoc.bsky.social · Dec 5

#Publixsub FTW > Moffit or Coronado pizza #amirite

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Stephen Oh @mpndoc.bsky.social · Nov 29

Very exciting Beth, congrats to your team and looking forward to these presentations!

Reposted by Stephen Oh

Anand Patel @anand-88-patel.bsky.social · Nov 29

very cool paper by @mpndoc.bsky.social et al looking at RSK1 as a therapeutic target in FLT3-ITD AML!

www.nature.com/articles/s41...

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Stephen Oh @mpndoc.bsky.social · Nov 28

Stay tuned for our companion manuscript which we anticipate sharing soon 😀. Finally, check out my talk on this work at the #ASH24 Scientific Workshop on Therapy Resistance Mechanisms in Blood Malignancies!
@ash-hematology.bsky.social
ash.confex.com/ash/2024/web...

Stephen Oh @mpndoc.bsky.social · Nov 28

Also grateful to long-time collaborator Grant Challen as well as Sandi Dunn and Phoenix Molecular Designs for working closely with us on this effort. Excited to move this concept into the clinic in the near future!

Stephen Oh @mpndoc.bsky.social · Nov 28

Finally, we demonstrated that the first-in-class RSK inhibitor PMD-026 ameliorated leukemic disease burden across multiple FLT3-mutant animal models. These findings illustrate an unconventional and promising therapeutic strategy targeting FLT3-ITD leukemia.