In this Review, the authors highlight cancer cachexia as a complex and multifactorial disorder, and discuss the underlying host-driven and tumour-driven metabolic changes, therapeutic opportunities and the pertinent challenges in the treatment of cancer cachexia.

Xu et al. identify the MondoA–TXNIP signalling axis as a regulator of antitumour immune surveillance in response to lactic acid in the tumour microenvironment.

In this Review, the authors provide a detailed overview of insulin signalling and its dysfunction, highlighting new therapeutic opportunities.

Job Title: Associate or Senior Editor (Nature Metabolism and Nature Communications) Location(s): New York, Jersey City, Philadelphia, Beijing or Shanghai Application Deadline: October 26th, 2025 About...

Nature Metabolism, Published online: 02 October 2025; doi:10.1038/s42255-025-01395-7The recent developments in artificial intelligence (AI) have created both intrigue and apprehension in the world of research. In this Viewpoint, we asked 12 experts in the field of metabolism to share their — differing — opinions on the use of AI in pre-clinical and clinical metabolic research.

Here, we introduce Artificial Intelligence Ready and Equitable Atlas for Diabetes Insights (AI-READI), a multidisciplinary data-generation project designed to create and share a multimodal dataset optimized for artificial intelligence research in type 2 diabetes mellitus.

Intercellular mitochondria transfer has recently attracted substantial attention, both from a fundamental and therapeutic point of view. At the same time, the topic continues to be met with scepticism. In this Viewpoint, different experts in mitochondrial biology share their personal view on the topic.

Nature Metabolism, Published online: 09 October 2025; doi:10.1038/s42255-025-01357-zInfant ketones during breastfeeding reprogram adipose progenitors via epigenetic modifications, driving beige fat development. This confers lifelong obesity resistance and prevents metabolic disease.

Nature Metabolism, Published online: 09 October 2025; doi:10.1038/s42255-025-01378-8In the context of parental or diet-induced obesity, preweaning ketosis contributes to improved health outcomes, particularly by regulating the histone acetylome and β-hydroxybutyrylome for transcriptional activation of beige fat biogenesis genes.

Rutter and Benninger discuss the role of putative controlling beta-cell populations in the context of intra-islet connectivity, how such a cellular hierarchy might be achieved and its potential role in islet physiology and diabetes.

Job Title: Associate or Senior Editor (Nature Metabolism and Nature Communications) Location(s): New York, Jersey City, Philadelphia, Beijing or Shanghai Application Deadline: October 26th, 2025 About...

Nature Metabolism, Published online: 07 October 2025; doi:10.1038/s42255-025-01382-yA 12-month multicentre randomized clinical trial finds that replacing added sugar in foods and beverages with sweeteners and sweetness enhancers supports modest weight loss maintenance and alters gut microbiota composition, with no safety concerns identified.

Nature Metabolism, Published online: 07 October 2025; doi:10.1038/s42255-025-01381-zThe SWEET project is a multicenter, randomized, controlled trial that shows that long-term consumption of sweeteners and sweetness enhancers improves body weight control and elicits beneficial gut microbiota changes in adults with overweight or obesity.

Holst reflects on the development of GLP-1-based drugs for the therapy of obesity, from early observations to remarkable results in more recent clinical trials, discussing physiological, pharmacological and clinical considerations related to their use.

Breit and Tsai provide a concise overview of the role of GDF15 as a signalling molecule in the context of metabolic health and disease.

Nature Metabolism, Published online: 30 September 2025; doi:10.1038/s42255-025-01367-xSaber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.

Dietary cysteine enhances intestinal stem cell-mediated intestinal repair following injury by promoting CD8 T cell-regenerative immune responses.

The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

This authoritative Perspective lays a foundation for the field of obesity research by comparing commonalities and differences between competing models of obesity pathogenesis and by defining terms that are at the core of this discussion.

Extracellular vesicles (EVs) are now recognized as powerful modulators of metabolism, and thus the new field of EV-mediated metabolic regulation is growing exponentially. Here, we discuss special experimental considerations for the study of EV function in metabolism.

McGettrick et al. provide a succinct yet broad overview of the immunometabolite itaconate as an immunomodulatory molecule.

Despite the high utility and widespread use of Cre driver lines, lack of Cre specificity, Cre-induced toxicity or poor experimental design can affect experimental results and conclusions. Such pitfalls must be considered before embarking on any Cre-based studies in metabolic research.

Nature Metabolism, Published online: 26 September 2025; doi:10.1038/s42255-025-01361-3In this issue of Nature Metabolism, Wang et al. identified a non-apoptotic caspase-8 function in metabolic dysfunction-associated steatohepatitis (MASH), in which hepatocyte-derived caspase-8 induces meteorin, which in turn activates hepatic stellate cells (HSCs) to drive fibrosis. This function reveals a potential therapeutic target to directly address fibrosis and reduce the progression of metabolic dysfunction-associated steatotic liver disease (MASLD).

Nature Metabolism, Published online: 26 September 2025; doi:10.1038/s42255-025-01355-1Hepatocyte caspase-8 in MASH promotes the activation of hepatic stellate cells and liver fibrosis through an apoptosis-independent mechanism

Nature Metabolism, Published online: 02 October 2025; doi:10.1038/s42255-025-01395-7The recent developments in artificial intelligence (AI) have created both intrigue and apprehension in the world of research. In this Viewpoint, we asked 12 experts in the field of metabolism to share their — differing — opinions on the use of AI in pre-clinical and clinical metabolic research.