Combining fossil-based and molecular calibrations with data on horizontal gene transfer events, the authors develop a time-calibrated phylogeny of Fungi. This timescale, which integrates analytic uncertainties, suggests an older age of crown Fungi (1,401–896 million years ago), as well as a minimum age for ancient interactions involving fungi and the algal ancestors of embryophytes in terrestrial ecosystems (1,253–797 Ma).

People with the inflammatory skin disease are at greater risk of neuropsychiatric conditions. Researchers are trying to find out why.

To mark World Mental Health Day 2025, we are sharing a selection of Springer Nature journal articles, collections, clinical study registrations and blog posts chosen by our publishers.

If erythrocyte invasion is blocked during the blood stage of infection by Plasmodium parasites, malaria can be prevented. In this Review, structural insights on erythrocyte invasion by the merozoite form of Plasmodium are discussed in the context of rational design of a blood-stage malaria vaccine.

The most common destination for eventual Nobel laureates in physics, chemistry and medicine since 2000 is the United States, Nature has found.

When clinical trials are suddenly halted by US funding cuts, there are repercussions for investigators and patients, and they do not stop at borders.

Other researchers question whether autonomous AI scientists are possible or even desirable.

A systematic review and meta-analysis of clinical trials investigating the efficacy and safety of obesity management medications reported tirzepatide and semaglutide to be the most effective in reducing body weight and obesity-related complications.

Human actions have shaped ecosystems for thousands of years, and have profound effects on biodiversity and environmental processes. This Review explores the ways that humans have modified past ecosystems and the methods available for researchers to study these changes, as well as indicating how understanding historic change can inform conservation strategies.

The 2025 Nobel Prize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.”

Marine ecosystems face threats from human-induced stressors like climate change, pollution, and habitat loss. Despite international endeavors, significant gaps remain in understanding ocean dynamics. This article presents six policy recommendations to integrate plankton populations into conservation frameworks. These could be leveraged in the process approved at CBD’s COP16 in Colombia to update criteria for defining ecologically or biologically significant marine areas (EBSAs) and supporting science-based Marine Protected Area (MPA) designations.

Susumu Kitagawa, Richard Robson and Omar Yaghi pioneered the creation of metal-organic frameworks, which can capture and store molecules such as carbon dioxide.

The Nobel Prize in Physics 2025 was awarded to John Clarke, Michel H. Devoret and John M. Martinis "for the discovery of macroscopic quantum mechanical ...

In 1985, experiments revealed the quantum behaviour of a macroscopic degree of freedom: the phase difference across a Josephson junction. The authors recount the history of this milestone for the development of superconducting quantum circuits.