partwave∴
@partickle.bsky.social
1.3K followers 5.6K following 16K posts
Post and be damned; I stand (auto) corrected --- LOC: ... ethereal knoll ...; ../ Daisyworld & wood wide web || nonlocality ;sans faceboot / x --- digitaly indistinguishable from spam (difs) ---- banner.img art from bsky.app/profile/hanaayoob.co.uk
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partickle.bsky.social
if you read
some drivel i post
(do let me know if my *numerous errors* are obvious to you)
*spelling excluded 😅
bsky.app/profile/gera...
gerardharbison.bsky.social
When I ran a research group, I'd tell my students that when you appear to have uncovered something anomalous, the first thing you say to yourself is "I fucked up". And the second thing you say is "I'm so stupid I can't even see where I fucked up".

No one is teaching Elon's script kiddies this.
Reposted by partwave∴
drannecarpenter.bsky.social
The change is subtle and not consistent for all patients so this isn’t useful as a diagnostic. Instead, we are excited because we can now test thousands of candidate drugs in skin cells to see if any will make the mito location more normal. Which could then be developed and tested in patients.
Reposted by partwave∴
drannecarpenter.bsky.social
I’d think fewer mito at the synapses means LESS signaling and therefore depression, not psychosis. But weirdly, researchers recently found that mito in brain cells consume energy (ATP) rather than produce it! So that makes sense, fewer mito would mean more energy near synapses and more signaling.
Reposted by partwave∴
drannecarpenter.bsky.social
Brain cells (neurons) have long skinny arms with synapses near the ends. It’s speculation, but we think that if mito aren’t getting to the very ends of those arms, that could cause signaling problems for the brain cells.
Reposted by partwave∴
drannecarpenter.bsky.social
For those patients the mito tend to stay away from the cell edge (in skin cells). Skin cells are relatively compact so it probably doesn’t matter too much. But we see the same pattern in actual brains (in our prior paper) where we bet the mito location matters a lot more (& may be causing symptoms)…
Reposted by partwave∴
drannecarpenter.bsky.social
Thrilled to! Mitochondria are a part of the cell that helps convert food into energy. Normally they are distributed throughout the cell (except for the nucleus, where the DNA/genes are). But we found a subtle shift in location for patients with psychosis (including schizophrenia & bipolar)…
Reposted by partwave∴
loeffelsoflove.bsky.social
I want to understand this so badly. Can you explain it very simply to someone who has no previous basis of understanding
Reposted by partwave∴
drannecarpenter.bsky.social
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
mitochondria from bipolar patients are closer to the nucleus in these images; control patients' are spread out further
Reposted by partwave∴
coestar.live
famous guy doesn't believe in wheels
appointed head of "department of cars"
now all cars lie flat on the ground
journalists argue whether cars need wheels to move
fossil fuel stock values plummet
executive order mandates all cars to run 3h/day
fossil fuel stock values rocket
everyone dies
Reposted by partwave∴
norabombay.bsky.social
Again and again, the discovery of why things like banking regulations exist. So close to getting it.
augustjpollak.bsky.social
I love how the big news on Trump’s tariff announcement is how moments before he made it a bunch of people made insanely profitable shorts on crypto, a thing that Bitcoin Bros are all astounded to see happening in a completely unregulated market of a fake currency primarily used by criminals.
BREAKING: Look at this.

A new crypto account was opened yesterday morning.

30 minutes BEFORE Trump's announcement of 100% tariffs on China, it added a huge multi-million dollar levered Bitcoin short position, per YF.

The market dumped.

The trader made a profit of $192 million in two hours.

Unusual. JUST IN: An anonymous trader opened massive crypto short positions just 30 minutes before Trump’s tariff announcements yesterday.

They made an estimated $192M in profits.
Someone knew the market would crash….

A Random brand new fresh wallet opened a massive $BTC short just 30 minutes before Trump’s tariff announcement and this trader made $88,000,000 profits. Donald Trump needs to go to jail. He is thief, he is literally robbing people internationally. 

He announced 100% Tarrifs on China and sends the US stock market into a death spiral. 

At the same time someone put over 1 Billion dollars into crypto with orders for 100 million being placed on Ethereum and Bitcoin and other crypto currencies across the board whilst markets got wiped after what he said. Billions, and I mean fucking billions got wiped out, whilst Bitcoin had it a biggest dip ever in a single candle losing 20k per Bitcoin, Whilst alt coins lost over 60-70% of value, everyone with leverage on the market with even 2 x leverage got murdered and robbed. 

This was co ordinated, this was market manipulation with one anonymous wallet making over 200 million dollars in one day with trades showing that they knew Trump was going to announce this and crash the market.
Reposted by partwave∴
meganpiont.bsky.social
The Spanish language zines have really been a group effort. Many thanks to @kimtillman.bsky.social, Rommel and the Marin Promise Partnership, @mediaperuana.bsky.social, Leah and @taniazsk.bsky.social!!!

You can find them here: drive.google.com/drive/folder...
Hand holding Spanish “how to report ICE” zines Spanish ALERTA protocol