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Episode 31 - Can We Stop Eculizumab? Postpartum Kidney Risk & SGLT2 Electrolyte Effects

Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · Sep 2

Episode 30 - Exercise, Diet, and Spironolactone in CKD: What's the Latest?

Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · Aug 18

In this episode of Podocyte Talk, we delve into three important studies shaping the management of advanced chronic kidney disease (CKD):

🔹 Exercise Before Dialysis

🔹 Cost-Effectiveness of Low-Protein Diets

🔹 Spironolactone in CKD

#podocytetalk #Nephpearls #Nephrology #CKD

youtu.be/NFMi6Ysez5w

Episode 29 - GFR After Bariatric Surgery, Pregnancy in CKD, and DAPA Quality of Life Benefits

Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · Aug 2

In Episode 29 of Podocyte Talk, we cover three high-impact studies:

Measured GFR After Bariatric Surgery

Pregnancy and Long-Term Kidney Function in Chronic Kidney Disease

Dapagliflozin and Health-Related Quality of Life

#podocytetalk #Nephpearls #Nephrology #CKD

youtu.be/yUfhuKXL_-s

Episode 28 - Exercise During Dialysis, Kidney Function in Heart Failure, and Transplant Infections

Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · Jul 15

In Episode 28 of Podocyte Talk, we discuss three clinically relevant studies advancing care in nephrology and transplant medicine:

Intradialytic Exercise Trial .

EVEREST Post-Hoc Analysis.

Transplant Infection Study (India).

#podocytetalk #Nephpearls #Nephrology #CKD

youtu.be/LEh0boi4Ovc

Episode 27 - GLP-1 RAs in Dialysis, Biomarkers in CKD, and Foam Sclerotherapy in Polycystic Disease

Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · Jul 1

🎙️New #PodocyteTalk!
GLP-1 RAs reduce death & boost transplant listing in dialysis.
Biomarkers predict CKD outcomes.
Sotradecol foam shrinks cysts in ADPKD/ADPLD.
📺 Watch & subscribe—85% of viewers still haven’t!
🔗 youtu.be/GKCeZsl1s2M
#nephrology #CKD

Episode 26 - Can We Do More for Diabetic Kidneys?

Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · Jun 16

🎙️ In Ep. 26 of Podocyte Talk:
– Finerenone + empagliflozin: better together in DKD
– Hypoglycaemia common post-dialysis in older adults
– Tirzepatide lowers albuminuria in obesity, with/without diabetes
Listen now! #CKD #Nephrology #Diabetes #GLP1

youtu.be/NiNvQYVdhIw

Episode 25 - Early Albuminuria and AF | Long-Term Rituximab in MN | Pulmonary HTN & Transplant Risk

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · Jun 5

Dual therapy with finerenone + empagliflozin cut albuminuria by ~30% more than either drug alone in CKD + T2D—with no added safety concerns.
A promising step for combo treatment in DKD.
#CKD #T2D #SGLT2i #Finerenone #CONFIDENCE #Nephrology #BlueskyMD

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · Jun 1

Episode 25 of Podocyte Talk is out!
🎧 Albuminuria predicts AF in the elderly
💉 Rituximab shows >95% 10-yr renal survival in MN
🫁 Pre-KTx pulmonary HTN = higher graft loss
Smart nephrology insights you can use.
#CKD #Nephrology #Podcasts

youtu.be/EO0eLgu6uuw

Episode 24 - SGLT2i vs GLP-1RA, Finerenone & eGFR Drop, and Carbs in Dialysis

Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · May 15

Podocyte Talk Episode 24:
– SGLT2i vs GLP-1RA in real-world CKD care
– Finerenone works regardless of early eGFR drop
– High-carb diets raise mortality in dialysis patients

#Nephrology #KidneyCare #Finerenone #SGLT2i #GLP1RA
#podocytetalk #Nephpearls #Nephrology #CKD

youtu.be/uMbtbhPYBPc

Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · May 11

Simultaneous initiation of SGLT2i, RASi, ns-MRA, and GLP1-RAs presents a promising approach to mitigate the risk of CV events and the progression of kidney disease in patients with CKD.
#podocytetalk #Nephpearls #Nephrology #CKD

journals.lww.com/jasn/abstrac...

Comparative Effectiveness of Glucagon-Like Peptide-1 Receptor Agonists and Sodium/Glucose Cotransporter 2 Inhibitors in Preventing Chronic Kidney Failure and Mortality in Patients With Type 2 Diabetes...

Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · May 10

Finerenone reduced kidney and cardiovascular events in CKD and T2D patients, regardless of frailty. Benefits included lower albuminuria and slower eGFR decline, supporting its use even in frail individuals.

#podocytetalk #Nephpearls #Nephrology #CKD

journals.lww.com/cjasn/abstra...

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · May 7

Patients receiving SGLT2i demonstrated lower rates of progression to KRT compared to those receiving GLP1RA. These findings may inform the choice of these therapies in the setting of CKD and T2DM.

#podocytetalk #Nephpearls #Nephrology #CKD #nephsky

www.ajkd.org/article/S027...

Both glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium/glucose cotransporter 2 (SGLT2) inhibitors improve cardiovascular, kidney, and survival outcomes in patients with type 2 diabetes; ...

www.ajkd.org

Analysis of the prespecified FIDELITY pooled patient dataset examined the efficacy and safety of finerenone in patients with an acute change in estimated glomerular filtration rate.

Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · May 5

In patients with CKD and T2DM, finerenone reduced cardiovascular and kidney events regardless of whether eGFR rose or declined in the first month. Even with >10% acute eGFR drop, benefits were preserved.
#podocytetalk #CKD #Nephsky
www.kidney-international.org/article/S008...

The efficacy and safety of finerenone (a non-steroidal mineralocorticoid receptor antagonist) versus placebo were assessed according to different changes in estimated glomerular filtration rate (eGFR)...

www.kidney-international.org

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · May 5

In a diverse IgAN cohort, 36% reached kidney failure, major eGFR decline, or died within 2.7 years. Proteinuria ≥0.5 g/g strongly predicted poor outcomes, challenging past beliefs that <1 g/g is low risk.

#podocytetalk #Nephpearls #Nephrology #CKD #nephsky

academic.oup.com/ndt/advance-...

Pre-treatment GFR slopes predict dapagliflozin response in IgA nephropathy

Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · May 4

Kidney outcomes were poor in genetic nephrotic syndrome; in FSGS outcomes were strongly associated with proteinuria level. MCD patients had better proteinuria control than FSGS and had better outcomes at each proteinuria level.
#podocytetalk #Nephpearls #nephsky

journals.lww.com/jasn/abstrac...

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · May 4

In IgA nephropathy, dapagliflozin slowed eGFR decline, especially in patients with faster pre-treatment loss. The pre-treatment eGFR slope predicted post-treatment benefit, suggesting value in guiding therapy.
#podocytetalk #CKD #GN #Nephsky

www.kireports.org/article/S246...

Dapagliflozin exerts renoprotective effects in patients with IgA nephropathy (IgAN). However, the association between the pre-treatment estimated glomerular filtration rate (eGFR) slope and post-treat...

www.kireports.org

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · May 4

In CKD, furosemide use—especially >100 mg/day—is linked to higher serum levels of protein-bound uraemic toxins like IS, PCS, Kyn, and IAA. Furosemide may impair toxin clearance via OAT1/3 transporters, contributing to toxin accumulation.
#podoctyetalk #CKD #Nephsky
www.kireports.org/article/S246...

Furosemide and Serum Protein-Bound Uraemic Toxin Concentrations in Patients with Chronic Kidney Disease

Furosemide is commonly prescribed to patients with CKD but may impair the kidney’s excretion of protein-bound uraemic toxins (PBUTs) via the organic anion transporters 1 and 3 (OAT1/OAT3). We evaluate...

www.kireports.org

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · May 1

In Episode 23 of Podocyte Talk, we dive into three important new studies: use of finerenone in IgA nephropathy, incidence and outcomes of acute kidney injury in very old patients, and risk of UTIs with SGLT2 inhibitors

#podocytetalk #Nephpearls #Nephrology #CKD #nephsky

youtu.be/X5dh2G-FAuI

Episode 23 - Finerenone in IgA Nephropathy, AKI in the Very Old, and SGLT2i UTI Risks

Episode 22 - Phosphate Binders, Cancer Risk & Early Treatment in CKD – Test Yourself with 2 MCQs

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Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · Apr 15

Podocyte Talk is now twice monthly! Each episode includes 2 multiple-choice questions—answer in the comments and test your nephrology knowledge!

In this episode, we explore three impactful studies in nephrology

#podocytetalk #Nephpearls #Nephrology #CKD

youtu.be/C1MQgOdVdv4

Episode 21 - Breakthroughs in Kidney Care: SGLT2i in CKD, New Biomarkers, and Better Dialysis Flow

Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · Apr 1

✅ SGLT2 inhibitors in patients with advanced CKD
✅ Anti-nephrin antibodies as relapse predictors in MCD & FSGS
✅ Sacubitril/valsartan improves dialysis access flow in heart failure

#podocytetalk #Nephpearls #Nephrology #CKD #nephsky

youtu.be/YkNoV6CDmxU

Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · Mar 28

Among low-risk patients undergoing PCI, contrast-associated AKI was rare, and withholding or continuing SGLT2 inhibitors had no impact on AKI risk or renal function. discontinuation in this setting may not be necessary.

journals.lww.com/kidney360/pa...
#Podocytetalk @asnpublications.bsky.social

Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · Mar 28

This study highlights the negative impact of hypertension early after kidney transplantation and emphasizes the importance of effective treatment to improve long-term graft and patient survival.

www.kireports.org/article/S246...

#Podocytetalk #nephrology #CKD #Nephsky

Episode 20 - BP Target in renal transplant, SGLT2i with contrast, and Glucose Monitoring in Dialysis

Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · Mar 24

BP targets post kidney transplant, SGLT2i use in angiography, and CGM insights in dialysis—all in Ep. 20 of Podocyte Talk. Tune in for key updates in nephrology! 🎧 #Nephrology #KidneyCare
#podocytetalk #Nephpearls #nephsky
youtu.be/fW2Ug1Sk9Rk

Episode 19 - Lupus nephritis, Phosphate Binders & Tolvaptan: Key Updates in Nephrology!

Podocyte Talk - Dr. Anass Qasem @podocytetalk.bsky.social · Mar 17

This week, we break down three major nephrology studies:
✅ Obinutuzumab’s role in lupus nephritis
✅ Best phosphate binders for dialysis patients
✅ Long-term effects of tolvaptan in ADPKD

#podocytetalk #Nephpearls #Nephrology #CKD

youtu.be/86pdnfUKlsA