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Rob Patro @robp.bsky.social · 7m

Does anyone have access to this paper genome.cshlp.org/content/earl... ?

An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms

genome.cshlp.org

Rob Patro @robp.bsky.social · 17m

yup --- www.ncbi.nlm.nih.gov/grc/human/is...

HG-2587 - Human genome issues - Genome Reference Consortium

www.ncbi.nlm.nih.gov

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Rob Patro @robp.bsky.social · 21m

Lol; this reminds me of @stevensalzberg.bsky.social's story about finding hamster genes in the human genome assembly's unplaced contigs ;P.

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Reposted by Rob Patro

Jeremy Simon @jeremymsimon.bsky.social · 3h

Incredible opportunity to go train with the Patro lab @umdscience.bsky.social and develop new genomic methods!

Rob Patro @robp.bsky.social · 4h

Hi bioinformatics, genomics and CS friends! Please help me spread the word. I'm hiring a postdoc! Come work on cutting edge method development in algorithmic genomics with me and my group at @umdscience.bsky.social! 🖥️🧬

Rob Patro @robp.bsky.social · 2d

And it's posted! If you're interested and eligible, please consider applying through the UMD portal: umd.wd1.myworkdayjobs.com/en-US/UMCP/j....

If you're a PI working in algorithmic genomics (& you can recommend my lab to your top graduating students ;P), please let them know!

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Rob Patro @robp.bsky.social · 4h

Hi bioinformatics, genomics and CS friends! Please help me spread the word. I'm hiring a postdoc! Come work on cutting edge method development in algorithmic genomics with me and my group at @umdscience.bsky.social! 🖥️🧬

Rob Patro @robp.bsky.social · 2d

And it's posted! If you're interested and eligible, please consider applying through the UMD portal: umd.wd1.myworkdayjobs.com/en-US/UMCP/j....

If you're a PI working in algorithmic genomics (& you can recommend my lab to your top graduating students ;P), please let them know!

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Rob Patro @robp.bsky.social · 4h

of specific algorithms to new variants of a problem, or reasonable type state code to ensure appropriate traditions and conversions. It’s not all simply in the experience or skill of the prompter, current systems are great at some tasks, good at many, and mediocre at some.

Rob Patro @robp.bsky.social · 4h

I don’t know what domain you work in, but my experience has been that the variability in AI quality between tasks in astronomical. I’ve seen it produce absolute wizardry in e.g. data visualization with just mild coaching, while simultaneously failing horribly to produce e.g. correct modifications …

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Rob Patro @robp.bsky.social · 14h

Yup!

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Reposted by Rob Patro

Andre Kahles @akkah21.bsky.social · 1d

After years of research and continuous refinement, we’re thrilled to share that our paper on the MetaGraph framework — enabling Petabase-scale search across sequencing data — has been published today in Nature (www.nature.com/articles/s41...)

Efficient and accurate search in petabase-scale sequence repositories - Nature

MetaGraph enables scalable indexing of large sets of DNA, RNA or protein sequences using annotated de Bruijn graphs.

www.nature.com

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Rob Patro @robp.bsky.social · 17h

I did say coding (my bad), but I was considering the case of software engineering, which involves certain problem solving and invention that I have seen AI fall completely flat on, even when gently guided toward a good solution in multiple different ways / through different prompts. 2/2

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Rob Patro @robp.bsky.social · 17h

Yea, I reject that characterization. The process of coding involves applying specific practices, often in subtly different ways, in different contexts. I have seen several different AIs mess that up horribly in different domains on multiple occasions. Also 1/2

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Reposted by Rob Patro

Robert Aboukhalil @robert.bio · 1d

Just published an interactive article about a magical algorithm known as the Burrows-Wheeler Transform, which powers sequence alignment tools like bowtie and bwa: sandbox.bio/concepts/bwt

It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.

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Rob Patro @robp.bsky.social · 1d

Agreed; 100%

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Rob Patro @robp.bsky.social · 1d

This endorsement means a lot to me! This is because Mohsen (a) was my student, and so knows not just about the work we do in the lab but also about what it's like to work with me as an advisor/mentor and (b) has long since graduated and so is under no duress to provide such an endorsement 🤣!

Mohsen Zakeri @mohsenzakeri.bsky.social · 1d

An awesome opportunity, strongly recommended to anyone looking for a postdoc in algorithms and genomics!

Rob Patro @robp.bsky.social · 2d

And it's posted! If you're interested and eligible, please consider applying through the UMD portal: umd.wd1.myworkdayjobs.com/en-US/UMCP/j....

If you're a PI working in algorithmic genomics (& you can recommend my lab to your top graduating students ;P), please let them know!

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Reposted by Rob Patro

Mohsen Zakeri @mohsenzakeri.bsky.social · 1d

An awesome opportunity, strongly recommended to anyone looking for a postdoc in algorithms and genomics!

Rob Patro @robp.bsky.social · 2d

And it's posted! If you're interested and eligible, please consider applying through the UMD portal: umd.wd1.myworkdayjobs.com/en-US/UMCP/j....

If you're a PI working in algorithmic genomics (& you can recommend my lab to your top graduating students ;P), please let them know!

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Rob Patro @robp.bsky.social · 1d

Oh man; long-form interview with @jonhoo.eu about Rust and other things! I can't wait to watch this: youtu.be/nOSxuaDgl3s?...

Rust 2025: 400K Salaries, AI, Defence & Borrow Checker — Jon Gjengset on Rust & the Future of Coding

YouTube video by JetBrains

youtu.be

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Rob Patro @robp.bsky.social · 1d

The Metagraph paper is out in Nature; it showed up in my feeds today! Congratulations to Mikhail Karasikov, @gxxxr.bsky.social, @akkah21.bsky.social and all of the other authors (whom I'd love to follow on Bluesky if I can find you ;P) www.nature.com/articles/s41...

Efficient and accurate search in petabase-scale sequence repositories - Nature

MetaGraph enables scalable indexing of large sets of DNA, RNA or protein sequences using annotated de Bruijn graphs.

www.nature.com

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Reposted by Rob Patro

Jon Gjengset @jonhoo.eu · 1d

In August, I was interviewed by JetBrains about programming and Rust, ranging from the borrow checker, to agentic coding, to hiring. And it's now on YouTube! It's also general enough that it should be interesting even to those not already knee deep in Rust 😅
www.youtube.com/watch?v=nOSx...

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Rob Patro @robp.bsky.social · 1d

Even if not, you'll Google it again in 6 years or so when you've forgotten about this episode ;P.

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Rob Patro @robp.bsky.social · 1d

I agree interviews are hard, but disagree that AI covers the whole field (by discrete areas, not size ... by size, much software is already trivial copypasta that AI can handle just fine). But 80% of the hard stuff is in a small number of places.

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Rob Patro @robp.bsky.social · 1d

And as my second post pointed out. If you don't need those skills, why hire a person?

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Rob Patro @robp.bsky.social · 1d

Because for certain important skill sets, that is manifestly not true.

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Rob Patro @robp.bsky.social · 1d

Don't forget to turnoff the AI!

www.google.com/search?q=how...

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Reposted by Rob Patro

David Buchanan @retr0.id · 3d

how to deactivate torment nexus

torment nexus deactivation tutorial

torment nexus deactivation tutorial working 2025

deactivate torment nexus no survey

77 1.5K 5.3K

Reposted by Rob Patro

Travis Wheeler @wheelerlab.org · 2d

Dream postdoc - Rob's science is excellent (and he's pretty great, too)

Rob Patro @robp.bsky.social · 2d

And it's posted! If you're interested and eligible, please consider applying through the UMD portal: umd.wd1.myworkdayjobs.com/en-US/UMCP/j....

If you're a PI working in algorithmic genomics (& you can recommend my lab to your top graduating students ;P), please let them know!

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