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Serdar Akkol, MD PhD @sakkol.bsky.social · 2d

#neurojobs

Serdar Akkol, MD PhD @sakkol.bsky.social · 8d

That's lovely. Curious to hear how you say CPS and your style were different and merged. Thank you again! Wondering if you have a post rock playlist you listen?

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Serdar Akkol, MD PhD @sakkol.bsky.social · 9d

Thank you for sharing your passion! It's thoughtful and really a joy to listen. It has been a while since hearing post rock in this way. Please continue CPS for us to feel deep and endless happiness of the world on days of darkness. 😌 Would love to hear your post rock playlist as well!

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Serdar Akkol, MD PhD @sakkol.bsky.social · 14d

Recently discovered @kerrymuzzey.bsky.social's post-rock project Candlepark Stars and I'm loving it. Been a while since I heard something like this. Much like Mono (Japan), @hammockmusic.bsky.social's "Departure Songs" or @explosionsinthesky.bsky.social! Thank you! open.spotify.com/artist/2o532...

Spotify – Web Player

open.spotify.com

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Serdar Akkol, MD PhD @sakkol.bsky.social · 18d

#neurojobs

Serdar Akkol, MD PhD @sakkol.bsky.social · 19d

Very interesting! #iEEG

Ben Hayden @benhayden.bsky.social · 19d

New manuscript from the lab!

"Mirror manifolds: partially overlapping neural subspaces for speaking and listening"

Led by superstar grad student Anilu Chavez (not on Bluesky)!

www.biorxiv.org/content/10.1...

Mirror manifolds: partially overlapping neural subspaces for speaking and listening

Participants in conversations need to associate words their speakers but also retain those words general meanings. For example, someone talking about their hand is not referring to the other speakers ...

www.biorxiv.org

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Reposted by Serdar Akkol, MD PhD

Serdar Akkol, MD PhD @sakkol.bsky.social · 26d

📢 Our paper published!! One of my PhD projects with @stephanbickel.bsky.social and Ashesh Mehta!
"Neural entrainment by speech in human auditory cortex revealed by intracranial recordings"
We tried to give a more nuanced picture of speech perception using #iEEG
www.sciencedirect.com/science/arti...

Neural entrainment by speech in human auditory cortex revealed by intracranial recordings

Humans live in an environment that contains rich auditory stimuli, which must be processed efficiently. The entrainment of neural oscillations to acou…

www.sciencedirect.com

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Serdar Akkol, MD PhD @sakkol.bsky.social · 26d

Learned a lot thanks to my wonderful co-authors, @akashmishra.bsky.social, Noah Markowitz, Elizabeth Espinal, Menoua Keshishian, Charles Schroeder, @nimail.bsky.social and my PhD advisors @stephanbickel.bsky.social and Ashesh Mehta. Happy to discuss more! Here's the free access link:

authors.elsevier.com

Serdar Akkol, MD PhD @sakkol.bsky.social · 26d

We believe our findings support the neural entrainment of oscillations during speech perception by acoustic edges. This is just another drop in the bucket of the vast literature on the neural oscillations. There is more to look and much to debate.

a blue background with a white light coming out of it

ALT: a blue background with a white light coming out of it

media.tenor.com

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Serdar Akkol, MD PhD @sakkol.bsky.social · 26d

This effect was localized to HG in theta and alpha bands and to STG in theta band only.

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Serdar Akkol, MD PhD @sakkol.bsky.social · 26d

If the phase concentration happened just because of the evoked potential, the 2nd cycle would have gone back to baseline values. However, what we see is that the ITPC stayed higher than the phase concentration happened before the evoked potential.

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Serdar Akkol, MD PhD @sakkol.bsky.social · 26d

Focusing on acoustic edges, we looked if the acoustic edge locked phase alignment (inter-trial phase coherence) lasts more than two cycles for events that are at least 800ms apart. We found ITPC lasts 2 cycles of theta band above the phase concentration that happens right before the acoustic edge.

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Serdar Akkol, MD PhD @sakkol.bsky.social · 26d

We initially replicated that both Heschl's gyrus and superior temporal gyrus have cerebro-acoustic coherence with speech in the theta range. But both HG and STG respond to the acoustic edge earlier than acoustic peak. As expected, since acoustic edges lead the acoustic peaks.

Cerebro-acoustic coherence between neurophysiological signal and the acoustic signal shows coherence most strongly in theta range. Acoustic peak locked evoked potentials deviate from baseline, earlier than the acoustic peak locked evoked potentials in both HG and STG.

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Serdar Akkol, MD PhD @sakkol.bsky.social · 26d

We tried to replicate these findings using intracranial EEG as there are several differences between MEEG and iEEG.
Our participants (I don't like calling them patients since they give their best effort and do this for science without return) listened to ~45min of speech stimuli.

Example speech stimulus marking acoustic edge and peaks, density plot of intervals between acoustic edge and peaks, electrode localizalization on a common freesurfer-average brain

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Serdar Akkol, MD PhD @sakkol.bsky.social · 26d

One elegant way to answer the difference is by looking at the phase alignment after an evoked activity as elegantly proposed by @oganiany.bsky.social et al.
www.jneurosci.org/content/43/2...

Phase Alignment of Low-Frequency Neural Activity to the Amplitude Envelope of Speech Reflects Evoked Responses to Acoustic Edges, Not Oscillatory Entrainment

The amplitude envelope of speech is crucial for accurate comprehension. Considered a key stage in speech processing, the phase of neural activity in the theta-delta bands (1-10 Hz) tracks the phase of...

www.jneurosci.org

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Serdar Akkol, MD PhD @sakkol.bsky.social · 26d

Two hypotheses emerged as potential mechanisms in understanding how we perceive speech:
Neural entrainment of oscillations has amassed much attention due to its flexibility and rich background.
Evoked response hypothesis explains what we see as a combination of ongoing responses to auditory stream.

a man in a suit and tie is standing in front of a handicapped men 's bathroom .

ALT: a man in a suit and tie is standing in front of a handicapped men 's bathroom .

media.tenor.com

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Serdar Akkol, MD PhD @sakkol.bsky.social · 26d

📢 Our paper published!! One of my PhD projects with @stephanbickel.bsky.social and Ashesh Mehta!
"Neural entrainment by speech in human auditory cortex revealed by intracranial recordings"
We tried to give a more nuanced picture of speech perception using #iEEG
www.sciencedirect.com/science/arti...

Neural entrainment by speech in human auditory cortex revealed by intracranial recordings

Humans live in an environment that contains rich auditory stimuli, which must be processed efficiently. The entrainment of neural oscillations to acou…

www.sciencedirect.com

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Serdar Akkol, MD PhD @sakkol.bsky.social · 26d

Thank you!

Reposted by Serdar Akkol, MD PhD

Pierre Mégevand @vanmedge.bsky.social · 26d

"Neural entrainment by speech in human auditory cortex revealed by intracranial recordings"
Akkol and colleagues, Progress in Neurobiology 2025
#iEEG
www.sciencedirect.com/science/arti...

Neural entrainment by speech in human auditory cortex revealed by intracranial recordings

Humans live in an environment that contains rich auditory stimuli, which must be processed efficiently. The entrainment of neural oscillations to acou…

www.sciencedirect.com

1 1 1

Reposted by Serdar Akkol, MD PhD

Auditory-Visual Speech Association (AVISA) @avsp.bsky.social · Sep 11

Neural entrainment by speech in human auditory cortex revealed by intracranial recordings www.sciencedirect.com/science/arti... 12 people had intracranial electrodes & listened to natural speech oscillatory -> speech edge induced activity persisted after evoked responses thus ...neural entrainment?

Neural entrainment by speech in human auditory cortex revealed by intracranial recordings

Humans live in an environment that contains rich auditory stimuli, which must be processed efficiently. The entrainment of neural oscillations to acou…

www.sciencedirect.com

2 3

Serdar Akkol, MD PhD @sakkol.bsky.social · Sep 8

Timely review of the HFA based functional mapping of cortical functions. There some more stuff to do:
onlinelibrary.wiley.com/doi/epdf/10....

A critical review of high‐frequency activity for functional mapping in SEEG

You have to enable JavaScript in your browser's settings in order to use the eReader.

onlinelibrary.wiley.com

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Serdar Akkol, MD PhD @sakkol.bsky.social · Sep 5

Well, good news, one paper got accepted! 🎉 More details soon...

Reposted by Serdar Akkol, MD PhD

Brian Ervin, PhD @brianervin.bsky.social · Sep 4

Conversation Mapping in Action!

scienceblog.cincinnatichildrens.org/new-method-s...

#HGM #Epilepsy #Neurosurgery #iEEG #Neurophysiology

New Method Simplifies Brain Evaluations for Planning Epilepsy Surgery - Research Horizons

scienceblog.cincinnatichildrens.org

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Reposted by Serdar Akkol, MD PhD

Oscar Woolnough @owoolnough.bsky.social · Sep 3

As it's hiring season again I'm resharing the NeuroJobs feed. Add #NeuroJobs to your post if you're recruiting or looking for an RA, PhD, Postdoc, or faculty position in Neuro or an adjacent field.

bsky.app/profile/did:...

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Reposted by Serdar Akkol, MD PhD

andrea e. martin @andreaeyleen.bsky.social · Sep 3

Interested in doing a PhD with me and lacns.github.io? Or with any of the incredible fellows in the IMPRS School of Cognition www.maxplanckschools.org/cognition-en - apply before Dec 1st at cognition.maxplanckschools.org/en/application

Language and Computation in Neural Systems

We are an international group of scientists consisting of linguists, cognitive scientists, cognitive neuroscientists, computational neuroscientists, computational modellers, computational scientists, ...

lacns.github.io

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