Sebastian Greenhough
@sebgreenhough.bsky.social
240 followers 270 following 21 posts
Cell biologist and drug discovery scientist with Cancer Research Horizons. Based at the CRUK Scotland Institute in Glasgow.
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sebgreenhough.bsky.social
Update: Mini quiches not bad and some interesting science too. It’s a shame the IP landscape around organoids is so restrictive as I’d like to see more use of them in drug discovery.
sebgreenhough.bsky.social
Organoids Are Us 2025 is happening at the Scotland Institute this week. I didn’t sign up but might sneak a look at the posters and/or buffet later.
sebgreenhough.bsky.social
Things like this don’t surprise me, but I wish we could stop talking about biology in terms of rules. All we really have are models, which either have real-world applications or they don’t. Keep breaking those rules, ants.
sebgreenhough.bsky.social
Saw the number plate P53 APC today and can only assume that I work with whoever owns it.
sebgreenhough.bsky.social
Read all about our small molecule pan-Ras inhibitors below! A 15-year effort from a team who still can’t get enough of near-impossible drug targets. I was only at the fringes of the project myself but pleased to have helped out here and there. Great work all!
crhorizons.bsky.social
🎉 Congrats to our scientists at The Scotland Institute on their publication in the Journal of Medicinal Chemistry!

They’ve developed reversible Ras inhibitors with tunable affinity for active & inactive forms, a big step in #DrugDiscovery.

More: tinyurl.com/y45t4yy7
#OnMyHorizon @acs.org
sebgreenhough.bsky.social
Finishing out in style with a thought-provoking address from René Bernards on therapeutic overactivation of oncogenic signalling.

A great final day with a strong showing for immunogenic cell death including the first clinical data I’ve seen combining IAP & PD-1 inhibitors. Exciting! #BACR2025
René Bernards addressing the conference auditorium in the closing keynote.
sebgreenhough.bsky.social
All done with day 2 of #BACR2025. Lots of great immune stuff today - I believe neutrophils were mentioned more than 500 times but I’m here for it.
sebgreenhough.bsky.social
Back in Edinburgh for day 2 of the BACR meeting. A bit nostalgic for my old commute, but I’m glad I don’t now have to get a bus to Little France. Or Roslin.
The Scott Monument in Edinburgh on a sunny morning.
sebgreenhough.bsky.social
Day 1 of the British Association for Cancer Research 65th Anniversary Meeting. Some good stuff on DNA repair, nonsense-mediated decay, epigenetics, dormancy, metabolism and lots more.

Nice venue too - The Royal College of Physicians of Edinburgh. Back again tomorrow! @thebacr.bsky.social #BACR2025
A busy conference auditorium awaits the first speaker. The ornate ceiling of the Great Hall featuring gold pillars, statues, elaborate plasterwork and a chandelier. The Progress Pride flag flies outside the main entrance.
sebgreenhough.bsky.social
Congratulations on the move! I did my undergrad in Bath and it’s one of my favourite cities in the world.
sebgreenhough.bsky.social
Enjoyed visiting the Crick for the first time this week. Also if you’re in the area and need a breather then the nearby stretch of Regent’s Canal is lovely.
The Francis Crick Institute on a sunny spring day. Regent’s Canal on a sunny day. Barges, trees and waterfowl are visible. Ducks on Regent’s Canal, with greenery and a heron on the bank.
sebgreenhough.bsky.social
If you’re looking for an exciting immuno-oncology postdoc position in a great city then I would advise applying for this!
cruk-mi.bsky.social
We are recruiting #postdoctoral scientists to join @giampazolias.bsky.social and our Cancer Immunosurveillance group 🧪🥼🧫🦠

For full details of the position, please visit our website:

www.cruk.manchester.ac.uk/career/mi-24...

Closing date: 4th April

#OncoSky #CanSky #CancerResearch #microbiome
Job Advert for Postdoctoral Scientist in the Cancer Immunosurveillance Group

Salary £37,000-£44,852 dependent upon qualifications and experience

Job ID MI/24/55-2

Apply by 4th April 2025
sebgreenhough.bsky.social
The Athena Swan Gold Award celebration was genuinely better than quite a few weddings I’ve been to.
An Athena Swan Gold Award printed cake, ornately presented on a table with various other gold-themed cakes, bottles of sparkling wine, gold balloons & napkins, a cake knife and a server.
sebgreenhough.bsky.social
I’m very glad to have been able to help out with this as a member of the @scs-voice.bsky.social committee over the past few years. Great work everyone!
uofgcancersciences.bsky.social
We are incredibly proud to announce that the School of Cancer Sciences has been awarded the prestigious Athena Swan Gold Award ⭐
sebgreenhough.bsky.social
I’m a little late to the party, but this is a great read.
dev-journal.bsky.social
A case for broadening our view of mechanism in developmental biology

Read this Perspective Article from B. Duygu Özpolat @biyolokum.bsky.social , Swathi Arur @swathiarur.bsky.social and Mansi Srivastava:
https://journals.biologists.com/dev/article/152/2/dev204605/365016/
Word clouds summarizing answers to survey questions. (A) Question 1: In your area of work, what is the most common interpretation of the term ‘mechanism’ as applied to research questions? The most common word is 'Gene', followed by 'Process', 'Molecular' and 'Cell'. (B) Question 2: When you assess work in your field, what do you look for in terms of a mechanistic understanding of development? The most common word is 'Cell', followed by 'Look', 'Level', 'Process' and 'Gene'.
sebgreenhough.bsky.social
Just registered for this. Should be good!
cusystemsimmu.bsky.social
‪Science Seminar with Prof. Luke O'Neill on February 13th at 1pm on 'How Mitochondria Control Cytokines'.

Please register at www.eventbrite.co.uk/e/cardiff-un...

@lukeanthonyoneill.bsky.social
sebgreenhough.bsky.social
Hi everyone, it’s been a while!