Author | Lightnews

Shy Guy @shyguyfitness.bsky.social · Dec 11

The ketogenic diet triggers mitohormesis, improving mitochondrial health and resilience. It boosts antioxidants, reduces ROS, and enhances energy efficiency.

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Shy Guy @shyguyfitness.bsky.social · Dec 11

By enhancing mitochondrial function, KD could target:

• Neurodegenerative diseases (Alzheimer’s, Parkinson’s)
• Cancer
• Type 2 diabetes
• Cardiovascular diseases

KD is a systemic healer.

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Shy Guy @shyguyfitness.bsky.social · Dec 11

BHB directly influences cell health:

• Scavenges ROS.
• Prevents mitochondrial permeability (protecting cells).
• Supports mitochondrial biogenesis via PGC-1α, NRF-1, and TFAM pathways.

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Shy Guy @shyguyfitness.bsky.social · Dec 11

Neuroprotection - Studies on KD show:

• Enhanced hippocampal mitochondria function.
• Increased resistance to oxidative stress (less ROS, more antioxidants).
• Mitohormesis extends beyond the brain—KD protects liver, muscle, and other tissues.

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Shy Guy @shyguyfitness.bsky.social · Dec 11

KD increases mitochondrial uncoupling proteins (UCPs):

• UCP2/3 reduce ROS production by dissipating proton gradients.

• Protects against oxidative stress without compromising energy efficiency.

It’s a built-in antioxidant system!

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Shy Guy @shyguyfitness.bsky.social · Dec 11

Ketones (BHB) enhance antioxidant defenses by:

• Inhibiting histone deacetylases (HDACs)
• Activating transcription factors like FOXO3a and NFE2L2 (NRF2)

This boosts enzymes like:
• SOD2 (superoxide scavenger)
• Catalase (H2O2 remover)

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Shy Guy @shyguyfitness.bsky.social · Dec 11

How does KD work?

KD induces nutritional ketosis, shifting metabolism to fat and ketones (like BHB).

• Elevates ketones: 0.5–3mM BHB
• Reduces carbs (<50g/day) and moderates protein
• Enhances fat oxidation

Ketones fuel energy AND act as signaling molecules.

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Shy Guy @shyguyfitness.bsky.social · Dec 11

What’s mitohormesis?

It’s when mild stress from ROS upregulates:

1️⃣ Antioxidant defenses (e.g., SOD, catalase)
2️⃣ Mitochondrial capacity

This adaptation improves resilience against chronic diseases.

KD stimulates this through increased mitochondrial respiration.

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Shy Guy @shyguyfitness.bsky.social · Dec 11

Mitochondria are the cell's powerhouse, but impaired function leads to excess ROS (reactive oxygen species), which causes:

• Neurodegenerative diseases
• Cardiovascular issues
• Diabetes
• Cancer

Moderate ROS, however, trigger beneficial adaptations. This is mitohormesis.

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Shy Guy @shyguyfitness.bsky.social · Dec 11

Research (doi.org/10.1155/2018...) on KD and mitohormesis suggests it boosts antioxidant defenses, enhances energy production, and even extends lifespan.

Nutritional Ketosis and Mitohormesis: Potential Implications for Mitochondrial Function and Human Health

Impaired mitochondrial function often results in excessive production of reactive oxygen species (ROS) and is involved in the etiology of many chronic diseases, including cardiovascular disease, diab....

doi.org

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Shy Guy @shyguyfitness.bsky.social · Dec 10

Despite this, some nanoparticles, like aluminum, are successfully excreted. In fact, most of us urinate a few micrograms of aluminum every single day.

Shy Guy @shyguyfitness.bsky.social · Dec 10

However, nanoparticles are not so easily expelled. Many of them accumulate in the kidneys, infiltrating cells and tissues where they can remain for weeks, months, or even years.

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Shy Guy @shyguyfitness.bsky.social · Dec 10

Our kidneys play a crucial role as the body’s primary filter for these nanoparticles. They work to eliminate them by releasing the particles into our urine.

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Shy Guy @shyguyfitness.bsky.social · Dec 10

Did you know that every day, we consume micrograms of nanoparticles such as nano silica, titanium, silver, and aluminum—a fact backed by scientific research.?

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Shy Guy @shyguyfitness.bsky.social · Dec 10

Be cautious of products containing Zinc, including:

• SPF makeup
• Skincare products
• Zinc supplements

Shy Guy @shyguyfitness.bsky.social · Dec 10

Regular Zinc is white.

Nano Zinc, however, is transparent.

This transparency allows manufacturers to create sunscreen that doesn’t leave a white film on your face while boasting "superior" nano features.

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Shy Guy @shyguyfitness.bsky.social · Dec 9

Take care of your myofascial system daily to stimulate collagen renewal, slow down aging, and restore your natural beauty.

How? I’m glad you asked! Subscribe to Anastasia’s channel and start applying her techniques today.

Link: www.youtube.com/@anastasiabe...

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Shy Guy @shyguyfitness.bsky.social · Dec 9

Sugar ages your skin through glycation, forming AGEs that stiffen collagen and damage repair mechanisms.

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Shy Guy @shyguyfitness.bsky.social · Dec 9

Beyond Skin: AGEs affect the whole body.

Elevated AGEs are linked to:

• Diabetes complications
• Heart disease
• Kidney failure
• Macular degeneration

AGE-reducing diets are a win for health AND beauty.

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Shy Guy @shyguyfitness.bsky.social · Dec 9

Why It Matters?

Skin aging isn’t just about looks. Glycation harms collagen, enzymes, and gut health while driving systemic inflammation. Reducing AGEs in your diet slows aging and boosts recovery from cosmetic procedures.

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Shy Guy @shyguyfitness.bsky.social · Dec 9

How to Fight Back Against Glycation:

• Limit sugar and refined carbs.

• Avoid high-heat cooking.

• Use spices like cinnamon, garlic, and turmeric, which inhibit AGE formation.

• Antioxidants (ginger, lipoic acid, flavonoids) also protect skin and body.

• Fast!

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Shy Guy @shyguyfitness.bsky.social · Dec 9

Glycation and Gut Health:

AGE-rich diets can disrupt gut microbiota, lowering beneficial bacteria. This reduces nutrient absorption, compounding damage to your skin and overall health.

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Shy Guy @shyguyfitness.bsky.social · Dec 9

It’s not just sugar in your diet!

Foods cooked at high temperatures (fried, grilled, roasted) are high in pre-formed AGEs.

Example: Boiled rice (1 AGE) vs. crispy rice cereal (220 AGEs).

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Shy Guy @shyguyfitness.bsky.social · Dec 9

Glycation starts early—by your late 20s, glycated collagen builds up at 3.7% per year!

In diabetes, glycation accelerates, but tight glycemic control can cut AGE formation by 25% in 4 months!

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Shy Guy @shyguyfitness.bsky.social · Dec 9

How AGEs (advanced glycation end products) form:

• Glycation occurs naturally but accelerates with high blood sugar.

• UV exposure boosts the process, compounding the damage.

• Cross-linking proteins not only harms skin but also affects organs like kidneys, eyes, and heart.

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