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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · 1d

Maternal diet shapes the next generation. Dr. Mike Thompson shared how obesogenic diets in mothers profoundly alter the gut microbiome and bile acid metabolism of offspring.
#PPI @washumedicine.bsky.social
@hepatocrinologist.bsky.social

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · 23d

Dr. Colin G. Nichols shared how the KATP channel drives both neonatal diabetes & congenital hyperinsulinism. 🧬 Key insights: SUR1 mutations, shifts in calcium sensitivity, & why diazoxide works (when sulfonylureas may not).
@washumedicine.bsky.social @colinnicholslab.bsky.social #EndoSky

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · 23d

Euglycemic DKA can develop in patients on SGLT2 inhibitors — even without diabetes. ⚠️ Important to counsel families on fasting and DKA symptoms as use of these meds grows in pediatric heart failure. @washumedicine.bsky.social
#Endocrinology #DiabetesCare #HeartFailure #MedTwitter

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · 25d

Sketchnote from Dr. Carmen Halabi’s talk:
👉 Lox is essential for elastin in large vessels
👉 Knockout = aortic aneurysms
👉 Early mortality in mice
👉 Why is the ascending aorta most at risk?
Big insights at the interface of genetics + vascular biology!
#Research @washumedicine.bsky.social

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Aug 8

🌟 Grand Rounds with Dr. Megan Cooper 🌟
One patient’s story can unlock diagnoses for dozens more. 🧬

From inborn errors of immunity to targeted therapies, genome sequencing is transforming care for #PrimaryImmuneDeficiency.

#Genomics #PrecisionMedicine #Pediatrics #RareDisease

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 16

That’s a wrap on #ENDO2025!
Thank you to the incredible speakers, attendees, and organizers who made this week unforgettable.

Sketching my way through the science was a blast—what was your favorite?
@endocrinesociety.bsky.social

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 15

Christoffer Clemmensen’s #ENDO2025 talk forecasted what’s coming next in obesity pharmacotherapy:
💉 Dual/triple/quad agonists (GLP-1, GIP, amylin, glucagon)
🧠 NMDA receptor targets = neuroplasticity
🔬 ghrelin → prevents regain
📉 GLP-1/GIP/meranzin combo↓

@endocrinesociety.bsky.social

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 15

Robert Semple at #ENDO2025 is pushing boundaries with deep mutational scanning of the #insulin receptor:
🔬 Testing all possible variants
🧩 Critical insights into cysteine-rich domains
🧠 Epitope mapping + therapeutic responsiveness
@endocrinesociety.bsky.social

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 15

Vincent Harley at #ENDO2025 identified 2 novel genes in 46,XY DSD:
🧠 MAP3K7 kinase domain variants—Sertoli-specific, WNT-β-catenin disruption
🧬 DMRT3 variants—potential estrogen activation & gain-of-function
@endocrinesociety.bsky.social
#DSD #Genetics

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 15

Luca Persani on behalf of Federica Marelli presented cutting-edge models of thyroid hormone resistance at #ENDO2025:
🐟 Zebrafish = functional platform for VUS
📉 Easier to ID THRβ defects via TFT signature
📘 Guidelines -specific variant interpretation
@endocrinesociety.bsky.social
#ThyroidGenetics

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 15

Tracy Rankin’s #ENDO2025 session was full of practical grant-writing advice:
✅ Know when to contact your program vs. review officer
✅ Tailor your career dev plan for Ks
✅ Plan for conceptual + technical pitfalls
✅ Be aware of timelines—and stay resilient!

@endocrinesociety.bsky.social #NIDDK

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 15

Jens Holst at #ENDO2025 called incretins “the silver bullet”—and for good reason:
💡 Modified GLP-1 has powerful central effects
🫀 Broad benefits: ↓ CV risk, ↓ inflammation, sleep apnea, MASH, Cancer?
🔑 Lifestyle change is key to keeping the weight off.
@endocrinesociety.bsky.social

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 14

🚨 Poster alert! I’ll be presenting MON-573 at #ENDO2025 today from 12–1:30 PM.
🧬 Come learn about novel GLUT4 (SLC2A4) variants in atypical young-onset diabetes
📊 Proud to be part of the #RADIANT -study and this incredible research community.
@endocrinesociety.bsky.social

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 14

At #ENDO2025, dinner with some of the most brilliant and kind-hearted Peds Endos I’ve ever met.
These are the moments that make conferences meaningful—connection, mentorship, and shared purpose.
@endocrinesociety.bsky.social #PedsEndo

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 14

#ENDO2025 “Meet the Professors” session featured Onno Holleboom & Eveline Bruinstroop with updates on MASLD:
🧬 FGF21 analogs + PPARδ = emerging therapies
📊 FIT-4 score + FibroScan = easy, non-invasive tools
🧠 GLP-1s may help too
@endocrinesociety.bsky.social
#MASLD

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 14

At #ENDO2025, Iza Machado shared key data linking puberty timing to adult cardiometabolic health:
📍 Early menarche = ↑ CV risk
📍 Late menarche = ↑ coronary artery disease
📊 Based on a large population cohort from Brazil

@endocrinesociety.bsky.social
#PubertyMatters #ENDO2025

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 13

Found my dose on the wall!
137 mcg Synthroid, powering me since 1994.
Here’s to #ENDO2025, long-term hormone therapy, and stable thyroid vibes 🦋#LevothyroxineLife @endocrinesociety.bsky.social @abbvie.bsky.social

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 13

At #ENDO2025, Melanie Haines emphasized the need to monitor muscle and bone health in patients on GLP-1 therapy:
🏋️‍♀️ Muscle loss is an under-recognized concern
👵 Women + older adults face higher risk
🦴 Bone resorption via CTX?
Whole-patient care matters.
@endocrinesociety.bsky.social

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 13

Rossella Cannarella at #ENDO2025 highlighted how tirzepatide might address more than just weight:
🧬 Effective for metabolic hypogonadism
🍆 Boosts sexual function
👶 May hold promise for fertility
🔍 Could Sertoli-sperm cell signaling be key?
Big questions, big potential.
@endocrinesociety.bsky.social

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 13

Angela Rao at #ENDO2025 discussed GLP-1 use alongside bariatric surgery:
💊 Adjunctive therapy is not statistically significant yet—but may benefit Class IV obesity
🧩 Calls for individualized care plans
📝 Recommends pre- and post-op GLP-1
@endocrinesociety.bsky.social

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 13

At #ENDO2025, Christian Roth introduced KCN1—a novel antibody hitting GLP1, MCHR, and MC5R.
🔬 Rat studies show improved glucose tolerance, weight loss, and fewer GI side effects.
🤓 Also: Did you know rats can’t vomit?
Precision obesity therapy may have a new contender. @endocrinesociety.bsky.social

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 13

Nancy Cox at #ENDO2025 dropped truths about the intersection of genomics + EHR data:
📊 Medical phenome analysis at Vanderbilt is transforming rare disease discovery
📢 “A diagnosis isn’t truth—it’s data”
What does this mean for the future of precision endocrinology? @endocrinesociety.bsky.social

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 13

“Not just a library—a learning system.”
Sir Mark Caulfield at #ENDO2025 highlighted the 100,000 Genomes Project is transforming diagnostics
✅ NHS-wide integration
✅ 25% rare disease Dx rate
What if this was the future of newborn screening?
@endocrinesociety.bsky.social @markcaulfield.bsky.social

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 13

Opening #ENDO2025 with urgency and hope.
In his presidential address, John Newell-Price reminded us what matters most:
🧠 Science.
🌍 Inclusivity.
🗣️ Advocacy.
Follow @endocrinesociety.bsky.social for updates and reflections throughout the meeting.

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Stephen Stone, MD 🔬🧬🐁✏️ @stevestonedraws.bsky.social · Jul 13

Thrilled to be attending my very first #ENDO2025!
I’ll be sketching my way through the conference, translating the latest endocrine science into visual snapshots.
Let’s make this one to remember. Follow along: @endocrinesociety.bsky.social ✍️🧬🧠

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