Determining the crystal structures of covalent organic frameworks (COFs) with atomic precision is pivotal for uncovering their properties and optimizing functionalities. However, the synthesis of high...

Using the Debus–Radziszewski reaction, eight imidazole-based macrocycles were synthesized from cyclotetrabenzil, while three oxazole analogs were prepared by the Davidson oxazole synthesis starting wi...

Aqueous anions play a crucial role in chemical and biological processes. They are traditionally classified as “structure makers” or “structure breakers” based on their impact on the viscosity of elect...

Carborane-substituted arenes have emerged as versatile building blocks in medicinal chemistry, materials science, and coordination chemistry owing to the unique three-dimensional aromaticity, exceptio...

Flexible covalent organic pillars (flex-COP-n) are adaptive nanotubular hosts formed via dynamic imine condensation. Their self-assembly displays an odd–even effect, yielding enantiomeric or meso dup...

A new strategy for catenane synthesis is reported that does not require persistent strong binding interactions on the components nor the addition of templates. Metal-free active template synthesis sp...

We repeat the earliest claimed [2]catenane synthesis, reported by Wasserman over 60 years ago, in order to ascertain whether or not a nontemplate, statistical synthesis by acyloin macrocyclization doe...

A novel thionating reagent, 7-phenyl-2,4,6,8,9-pentathia-1,3,5-triphosphaadamantane 1,3,5-trisulfide (1), bearing an S–P adamantane framework, has been developed as a practical and environmentally ben...

We design the macrocycles capable of stimuli-triggered, reversible transformation between nonhomeomorphic topologies (one-hole ring versus two-hole figure-eight ring). By leveraging the ring size cha....

Metal complexes with tunable ligands play a crucial role in olefin polymerization and impart control over molecular weight, crystallinity, and stereoregularity. We report the single-step synthesis of imine-phenoxy ligands in excellent yields (81–93%). The identity of electronically tuned imine-phenoxy ligands was unambiguously ascertained by using a combination of spectroscopic and analytical methods. These ligands were treated with [Pd(COD)MeCl] in the presence of 2,6-lutidine, resulting in the formation of discrete mononuclear palladium complexes Pd1–Pd4 in excellent yields. 1–2D NMR spectroscopy, mass spectrometry analysis, and single-crystal X-ray diffraction confirmed the identity of the palladium complexes. X-ray analysis revealed a distorted square planar geometry around the palladium center. Proton NMR analysis suggested that the Pd1 catalyst was deshielded, indicating electronically deficient palladium metal compared to the other complexes. Moreover, the Pd1 catalyst showed the highest buried volume percentage (%Vbur = 44.9). When exposed to norbornene, Pd1–Pd4 were found to be active and produced poly(norbornene) (PNB). High-temperature SEC analysis revealed that the electronically deficient and sterically hindered Pd1 catalyst produced the highest molecular weight polymer (PNB 37.4 kDa). Boron and aluminum-based cocatalysts were screened, and MMAO was found to outperform others with high catalytic activity (up to 63.2 × 105 g of PNB (mol Pd)−1 h–1).

New two-dimensional (2D) covalent organic frameworks (COFs) with a tri(oxa)azatriangulene (TANG) node and different polarity of the imine linkers (C═N vs N═C) and internode distance have been synthesi...

Precisely controlling the up- or down-regulation of catalysis in a biomimetic fashion is a challenging goal in supramolecular chemistry. Here, the inclusion complex of Mo8O264− within a metal–organic....

Macrocyclic hosts are pivotal in supramolecular chemistry, yet the discovery of synthetically scalable platforms that combine rich host–guest behavior, facile crystallizability, and solid-state functi...

Rotaxane organocatalysis presents a new direction toward controlled one-pot catalytic reactions. By combining molecular switches and catalysts, fluorescence and pH-responsive switching along with the ...

A series of new photoresponsive macrocyclic anion receptors were synthesized via integration of an azobenzene unit and multiple anion binding sites. They exhibited highly selective binding to dianioni...

A spirobipyridine ligand bearing a hydroxy group recognizes pyridine and quinoline substrates through hydrogen bonding, and in combination with an iridium catalyst enables C−H borylation with site se....

Herein we report a practical and highly efficient methodology for the β-selective synthesis of N-glycosides via Buchwald–Hartwig coupling. This glycosylation strategy employs glycosyl chloride with di...

What is the size limit for global aromaticity? How large can a macrocyclic π-system be and still exhibit an aromatic ring current around its circumference? We address this question by investigating a ...

The discovery of new weak supramolecular interactions and supramolecular synthons is essential for directing self-assembly processes with enhanced precision, diversity, and functionality in complex mo...

Direct photoreforming of waste poly(ethylene terephthalate) (PET) plastic into high-value-added chemicals is a promising method that improves resource utilization. However, the traditional method for ...

Unlike aromatic porphyrins, conventional oxidative coupling reactions do not yield dimeric or oligomeric antiaromatic porphyrinoids. We describe here the first example of a β–β-linked antiaromatic exp...

Artificial photosynthesis of hydrogen peroxide (H2O2) from water and oxygen is a green method, which requires catalysts that can complete oxygen reduction and water oxidation reactions simultaneously....

The quality of covalent organic frameworks is often compromised by structural damages induced during their activation procedure which influences their subsequent applications. Here, the authors descri...

Nature precisely regulates multicomponent assemblies with the assistance of cooperativity. However, establishing such high precision in multicomponent assemblies of artificial supramolecular structure...

An aromatic helical foldamer linked to a peptide rod, which is incapable of self-complexation or polymerization, has been shown to preferentially assemble through inter-strand hydrogen-bonding intera...

The selective recognition of hydrophilic carbohydrates in water remains a longstanding challenge in supramolecular chemistry due to solvent competition and the lack of a strong driving force comparabl...

The employment of multicomponent reactions enables the synthesis of the highest component [6+24+24] covalent organic cages featuring coronavirus-shaped structures. These cages are assembled through C...

Threefold symmetric hexa-cationic hydrazone cages coordinate a range of transition metal ions upon deprotonation. When the cage contains ethyl solubilising groups the expected threefold symmetric cag...