Xi Chen
@xichen.bsky.social
940 followers 750 following 28 posts
Assistant Professor of Integrative Neuroscience at Department of Psychology, SUNY - Stony Brook University || Postdoc @ UC Berkeley & Lawrence Berkeley Lab || PhD @ UT Dallas & CVL || Cognitive Aging, Alzheimer’s Biomarker, fMRI, PET 🧠 || drxichen.com
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xichen.bsky.social
🚨Please apply/RT! The Department of Psychology at Stony Brook University (SUNY- Stony Brook) is hiring a tenure track Assistant Professor in integrative neuroscience. We are in beautiful Long Island. Come work with us! apply.interfolio.com/171691 #neuroskyence #PsychSciSky @futurepislack.bsky.social
xichen.bsky.social
🚨If you are in Toronto for #AAIC25, come to room701 at 2pm today (Tuesday)! I’ll present in the developing topic session on tau biomarkers!🩸->🧠
Reposted by Xi Chen
sfnjournals.bsky.social
Apply for the opportunity to serve on JNeurosci’s Early Career Researcher Advisory Board to get more involved in scientific publishing and advocate as an early career researcher.
Learn more and submit your application by July 25, 2025, 5pm ET: https://www.jneurosci.org/content/ecr-board-applications
xichen.bsky.social
Hi Early Career Researchers (ECR) in neuroscience!🧠 I've had a great time working as an ECR advisory board member in the Journal of Neuroscience @sfnjournals.bsky.social and learned so much from my peers and journal editors! We now invite you to join us! @sfn.org www.jneurosci.org/content/ecr-...
xichen.bsky.social
With the first blood test for AD approved for clinical use, there may be great use of it to infer regional pathology when PET is not an option. Hasom Moon (the first author of the paper) is now studying the discordant cases to better understand and maximize the use of blood-based biomarkers!
xichen.bsky.social
With these relationships, we can use p-tau217 to estimate the staging/severity of tau in the brain🧠. The comparison between p-tau217-estimated tau map and actual tau PET shows high similarities(!) for both cross-sectional estimation (top) and longitudinal prediction (bottom)!
xichen.bsky.social
First paper from CHEN lab!🩸->🧠Can we use p-tau217 value to estimate PET-like map of AD pathology?🤔 We say YES!💡In two datasets (A4, ADNI), p-tau217 level can predict concurrent Ab (but NOT Ab change) and future tau accumulation almost everywhere!
www.sciencedirect.com/science/arti...
xichen.bsky.social
Come to sunny Puerto Rico ☀️ #HAI2025 and see our poster on the predictive value of plasma pTau217 on tau PET at the regional level! Please check out Poster No.80 on Thursday 16th! 🧠 🩸
a man with glasses and suspenders is standing in front of a group of people and says science !!
ALT: a man with glasses and suspenders is standing in front of a group of people and says science !!
media.tenor.com
Reposted by Xi Chen
relajoie.bsky.social
Working in this paper was a really fun collaboration with folks at AMYPAD, Lyduine Collij, Ariane Bollack, Gill Farrar and many others.
This should be a helpful piece for people who want to understand Centiloids!
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
xichen.bsky.social
I’d love to be added if possible! Thank you!
xichen.bsky.social
I’d love to be added if possible. Thank you!
xichen.bsky.social
I’d love to be added if possible! Thank you!
xichen.bsky.social
I’d love to be added if possible! Thank you!
xichen.bsky.social
I’d love to be added if possible! Thanks!
xichen.bsky.social
I’d love to be added! Thank you for creating it!
xichen.bsky.social
🤩 would love to be added!
xichen.bsky.social
Many thanks to my coauthors who are not on Bluesky!🙏 We are excited about these interesting results! It gives us more hope🤩 in localizing early pathology and neural deficits driving differential cog declines, which is part of my current research! (I'm recruiting PhD students🧑‍🎓 if you are interested!)
xichen.bsky.social
We think these specific pathology-cog relationships may be due to the regions' functional roles and the particular vulnerabilities of the frontal-parietal (executive) network to Aβ and temporal (memory) network to tau in the very early stage of AD development!
xichen.bsky.social
Then relating the domain-specific residuals to PET change, we found Aβ increases in right frontoparietal tracked EF decline, but not memory, even after controlling for tau change; tau increases in left MTL tracked memory decline, but not EF, after controlling for Aβ change -- a double dissociation?!
xichen.bsky.social
Using longitudinal data in 76 older adults from the Berkeley Aging Cohort Study (~3 yrs PET, ~5 yrs cog), we first calculated domain-specific cog change residuals that represent how much faster their EF declined than expected based on their rate of memory decline (and vice versa)
xichen.bsky.social
🚨 Please check out our new paper on a double (triple?) dissociation between early AD pathology and cognition: frontal-parietal Aβ increases related to executive function (EF) decline, but not memory; temporal tau increases related to memory decline, but not EF! www.sciencedirect.com/science/arti...
Longitudinal relationships between Aβ and tau to executive function and memory in cognitively normal older adults
The early accumulation of AD pathology such as Aβ and tau in cognitively normal older people is predictive of cognitive decline, but it has been diffi…
www.sciencedirect.com
xichen.bsky.social
The application deadline is Jan 15! Our PhD students are fully funded; if you are a US domestic student, we encourage you to apply before Dec 15 for consideration for additional fellowship!
#neuroskyence #psychscisky #psychjobs #academicsky #BlackInNeuro #Neuroimaging #cogpsyc #Psychology #PhDSky
xichen.bsky.social
‼️I am recruiting integrative neuroscience PhD students (fully funded) for this coming cycle Fall 2025 at SUNY-Stony Brook University.🧑‍🎓Email me if you are interested in cognitive aging, Alzheimer’s disease, and neuroimaging! 🧠 RT is appreciated! www.stonybrook.edu/commcms/psyc...
#neurojobs
Integrative Neuroscience | Department of Psychology
SUNY Stony Brook Psychology Integrative Neuroscience Overview
www.stonybrook.edu