Brandon Walters
@brandon.theepilab.ca
Professor of Biology at University of Toronto Mississauga. Specializing in Molecular Neuroscience, RNA modifications, and being grumpy! All views expressed are my own.
Always such great work from a great lab. Looking forward to the waves it makes!
New preprint! In 2014, we showed that histone variants are new regulators of memory and ever since, we wondered if histone H2A.Z contributes to Alzheimer's. Using human brains and 5xFAD mice, we found that it depends on if you're male or female. Summary below. www.biorxiv.org/cgi/content/...
Opposing effects of H2A.Z on memory, transcription and pathology in male and female Alzheimer's disease mice and patients
Alzheimer's disease (AD) is a devastating neurodegenerative disease that disproportionately impacts women, but underlying mechanisms for sex-divergent outcomes are unknown. Here, we show that the hist...
www.biorxiv.org
June 3, 2025 at 1:46 PM
Always such great work from a great lab. Looking forward to the waves it makes!
Reposted by Brandon Walters
New preprint! In 2014, we showed that histone variants are new regulators of memory and ever since, we wondered if histone H2A.Z contributes to Alzheimer's. Using human brains and 5xFAD mice, we found that it depends on if you're male or female. Summary below. www.biorxiv.org/cgi/content/...
Opposing effects of H2A.Z on memory, transcription and pathology in male and female Alzheimer's disease mice and patients
Alzheimer's disease (AD) is a devastating neurodegenerative disease that disproportionately impacts women, but underlying mechanisms for sex-divergent outcomes are unknown. Here, we show that the hist...
www.biorxiv.org
June 2, 2025 at 11:58 AM
New preprint! In 2014, we showed that histone variants are new regulators of memory and ever since, we wondered if histone H2A.Z contributes to Alzheimer's. Using human brains and 5xFAD mice, we found that it depends on if you're male or female. Summary below. www.biorxiv.org/cgi/content/...
To my American scientists. I don't know how you are gonna do this. I have a student applying for grad school in the US. 2 of the 4 programs she applied to have since cancelled their entire 1st year class.
This feels very much like Nero watching Rome burn...
This feels very much like Nero watching Rome burn...
March 5, 2025 at 12:32 AM
To my American scientists. I don't know how you are gonna do this. I have a student applying for grad school in the US. 2 of the 4 programs she applied to have since cancelled their entire 1st year class.
This feels very much like Nero watching Rome burn...
This feels very much like Nero watching Rome burn...
Was fun making a unique construct for this project! Congratz @sjo09 (on twitter), Sylvie and all involved!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice
Stress induces aversive memory overgeneralization, a hallmark of many psychiatric disorders. Memories are encoded by a sparse ensemble of neurons acti…
www.sciencedirect.com
November 15, 2024 at 4:51 PM
Was fun making a unique construct for this project! Congratz @sjo09 (on twitter), Sylvie and all involved!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Come see @Bowtie_IRL (on twitter) present his
MS work. "Charcterizing the role of m6A and Fto in the amygdala using a model of social instability stress in adolescence using a novel Fto fused Abobec1" Y24 this afternoon! #SFN2024. Thanks @CherylMMcC for this great colab!!
MS work. "Charcterizing the role of m6A and Fto in the amygdala using a model of social instability stress in adolescence using a novel Fto fused Abobec1" Y24 this afternoon! #SFN2024. Thanks @CherylMMcC for this great colab!!
October 8, 2024 at 3:38 PM
Come see @Bowtie_IRL (on twitter) present his
MS work. "Charcterizing the role of m6A and Fto in the amygdala using a model of social instability stress in adolescence using a novel Fto fused Abobec1" Y24 this afternoon! #SFN2024. Thanks @CherylMMcC for this great colab!!
MS work. "Charcterizing the role of m6A and Fto in the amygdala using a model of social instability stress in adolescence using a novel Fto fused Abobec1" Y24 this afternoon! #SFN2024. Thanks @CherylMMcC for this great colab!!
SFN 2024. Chicago really stepping up this year!
October 6, 2024 at 9:49 PM
SFN 2024. Chicago really stepping up this year!
2 in 1 year! How will my lab ever recover! I want to take this opportunity to congratulate Isabella (@bellagalluzzo3 on twitter) for successfully defending her M.S degree! Wonderful thesis and defence!
September 13, 2024 at 7:53 PM
2 in 1 year! How will my lab ever recover! I want to take this opportunity to congratulate Isabella (@bellagalluzzo3 on twitter) for successfully defending her M.S degree! Wonderful thesis and defence!
I have the honor of congratulating Luca (@Bowtie_IRL on twitter) for successfully defending his M.S. thesis! Well deserved and well defended! Now get started on that Ph.D.!
August 26, 2024 at 7:54 PM
I have the honor of congratulating Luca (@Bowtie_IRL on twitter) for successfully defending his M.S. thesis! Well deserved and well defended! Now get started on that Ph.D.!
My dissecting scope may look silly now, but give me a 3D printer and I can attach anything to anything.
October 10, 2023 at 8:46 PM
My dissecting scope may look silly now, but give me a 3D printer and I can attach anything to anything.