George Caputa
@curiousdrgeorge.bsky.social
senior editor at Nature for cellular & mitochondrial metabolism, metabolic physiology, cardiology, vascular biology, clinical science. All views my own.
nerdy | queer | they/m
nerdy | queer | they/m
For single cell foundation model fans, Raul Rabadan & colleagues just published GET in @nature.com, which trained on chromatin accessibility data to predict transcription factor interactions/motifs, cis-regulatory elements, & gene expression from 213 human cell types
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A foundation model of transcription across human cell types - Nature
A foundation model learns transcriptional regulatory syntax from chromatin accessibility and sequence data across a range of cell types to predict gene expression and transcription factor interactions...
www.nature.com
January 9, 2025 at 10:10 AM
For single cell foundation model fans, Raul Rabadan & colleagues just published GET in @nature.com, which trained on chromatin accessibility data to predict transcription factor interactions/motifs, cis-regulatory elements, & gene expression from 213 human cell types
www.nature.com/articles/s41...
www.nature.com/articles/s41...
First 2025 metabolism publication in @nature.com is from Michael Karin's group, finding that metabolic hepatosteatosis promotes senescence of hepatocytes, but is bypassed through transcriptional inactivation of FBP1, a novel gatekeeper against hepatocellular carcinoma
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Paradoxical link between senescent cell state and liver cancer resolved
DNA damage caused by a high-fat diet can increase the risk of tumour formation in the liver.
www.nature.com
January 9, 2025 at 10:03 AM
First 2025 metabolism publication in @nature.com is from Michael Karin's group, finding that metabolic hepatosteatosis promotes senescence of hepatocytes, but is bypassed through transcriptional inactivation of FBP1, a novel gatekeeper against hepatocellular carcinoma
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Two studies published recently in @nature.com proposed cryoEM structures of the lipoprotein apoB. Some of the biggest protein-lipid complexes ever visualized and some cool insights into lipoprotien bio.
January 9, 2025 at 9:48 AM
Two studies published recently in @nature.com proposed cryoEM structures of the lipoprotein apoB. Some of the biggest protein-lipid complexes ever visualized and some cool insights into lipoprotien bio.
Reposted by George Caputa
a great opportunity to join the Nature team: we're looking for a neuroscience editor, ideally with a strong record in systems neuro: springernature.wd3.myworkdayjobs.com/SpringerNatu...
Associate or Senior Editor, Nature
Job Title: Associate or Senior Editor, Nature Locations: New York or Berlin (Hybrid working model) Application Deadline: December 15th, 2024 About Springer Nature Group Springer Nature opens the doors...
springernature.wd3.myworkdayjobs.com
November 26, 2024 at 8:40 AM
a great opportunity to join the Nature team: we're looking for a neuroscience editor, ideally with a strong record in systems neuro: springernature.wd3.myworkdayjobs.com/SpringerNatu...
Reposted by George Caputa
We are delighted to share our latest findings in @natureportfolio.bsky.social! We describe cardiogenic regulation of sleep after cardiac injury.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Myocardial infarction augments sleep to limit cardiac inflammation and damage - Nature
Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic sign...
www.nature.com
November 14, 2024 at 5:13 PM
We are delighted to share our latest findings in @natureportfolio.bsky.social! We describe cardiogenic regulation of sleep after cardiac injury.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Sleeping is one of my fav activities. Very excited that we got to share this study by @mcalpinelab.bsky.social showing that cardiac inflammation after a heart attack dictates sleep patterns and promotes healing/recovery.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Myocardial infarction augments sleep to limit cardiac inflammation and damage - Nature
Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic sign...
www.nature.com
November 25, 2024 at 10:51 AM
Sleeping is one of my fav activities. Very excited that we got to share this study by @mcalpinelab.bsky.social showing that cardiac inflammation after a heart attack dictates sleep patterns and promotes healing/recovery.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A great study by @lydialynch.bsky.social 's group showing that IL-17 producing immune cells in adipose dictate the circadian rhythm of that tissue and orchestrate de novo lipogenesis and systemic metabolism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Rhythmic IL-17 production by γδ T cells maintains adipose de novo lipogenesis - Nature
Innate IL-17-producing T cells—in particular, adipose γδ17 T cells—are enriched in molecular-clock genes, and the circadian expression of IL-17A and RORγt by these cells has a role in maintaining loca...
www.nature.com
November 25, 2024 at 10:48 AM
A great study by @lydialynch.bsky.social 's group showing that IL-17 producing immune cells in adipose dictate the circadian rhythm of that tissue and orchestrate de novo lipogenesis and systemic metabolism
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Very cool paper by Craig Thompon's group spearheaded by @keunwooryu.bsky.social identifying distinct subpopulations of oxidative and reductive mitochondria.
Can't wait to see everyone check their fav cell types for these populations!
www.nature.com/articles/s41...
Can't wait to see everyone check their fav cell types for these populations!
www.nature.com/articles/s41...
Cellular ATP demand creates metabolically distinct subpopulations of mitochondria - Nature
Mitochondria are able to maintain two competing metabolic pathways—oxidative phosphorylation and the reductive synthesis of proline and ornithine—by generating two mitochondrial subpopulations that ar...
www.nature.com
November 25, 2024 at 10:44 AM
Very cool paper by Craig Thompon's group spearheaded by @keunwooryu.bsky.social identifying distinct subpopulations of oxidative and reductive mitochondria.
Can't wait to see everyone check their fav cell types for these populations!
www.nature.com/articles/s41...
Can't wait to see everyone check their fav cell types for these populations!
www.nature.com/articles/s41...
First post! Didn't see this study on @bsky.app.
From @zgerharthines.bsky.social group identifying neuronal NK2R as a regulator of feeding/hunger & energy expenditure, and demonstrating the efficacy of a small molecule agonist in non-human primates for weight loss.
www.nature.com/articles/s41...
From @zgerharthines.bsky.social group identifying neuronal NK2R as a regulator of feeding/hunger & energy expenditure, and demonstrating the efficacy of a small molecule agonist in non-human primates for weight loss.
www.nature.com/articles/s41...
NK2R control of energy expenditure and feeding to treat metabolic diseases - Nature
In mouse and nonhuman primate models, treatment with selective, long-acting neurokinin 2 receptor agonists aids weight loss by suppressing appetite and increasing energy expenditure, as well as b...
www.nature.com
November 25, 2024 at 10:41 AM
First post! Didn't see this study on @bsky.app.
From @zgerharthines.bsky.social group identifying neuronal NK2R as a regulator of feeding/hunger & energy expenditure, and demonstrating the efficacy of a small molecule agonist in non-human primates for weight loss.
www.nature.com/articles/s41...
From @zgerharthines.bsky.social group identifying neuronal NK2R as a regulator of feeding/hunger & energy expenditure, and demonstrating the efficacy of a small molecule agonist in non-human primates for weight loss.
www.nature.com/articles/s41...
Reposted by George Caputa
🧬 New in @Nature: Our team found that fat cells keep a “memory” of their previous obese state even after weight loss, helping explain why maintaining weight loss is so challenging. Excited to share this work!!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature
Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...
www.nature.com
November 19, 2024 at 5:12 AM
🧬 New in @Nature: Our team found that fat cells keep a “memory” of their previous obese state even after weight loss, helping explain why maintaining weight loss is so challenging. Excited to share this work!!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by George Caputa
‘A place of joy’: why scientists are joining the rush to Bluesky
For me, it certainly feels good to be here!
@natureportfolio.bsky.social @bsky.app
www.nature.com/articles/d41...
For me, it certainly feels good to be here!
@natureportfolio.bsky.social @bsky.app
www.nature.com/articles/d41...
‘A place of joy’: why scientists are joining the rush to Bluesky
Researchers say the social-media platform — an alternative to X — offers more control over the content they see and the people they engage with.
www.nature.com
November 22, 2024 at 6:49 AM
‘A place of joy’: why scientists are joining the rush to Bluesky
For me, it certainly feels good to be here!
@natureportfolio.bsky.social @bsky.app
www.nature.com/articles/d41...
For me, it certainly feels good to be here!
@natureportfolio.bsky.social @bsky.app
www.nature.com/articles/d41...