Kai Doberstein
@kai82do.bsky.social
Science, Biology, Fahrrad, Triathlon, Mannheim
Reposted by Kai Doberstein
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Naked mole rats get much older than closely related mamals of a similar size. cGAS mutations may have an important role in this.
www.science.org/doi/...
1/9
Naked mole rats get much older than closely related mamals of a similar size. cGAS mutations may have an important role in this.
www.science.org/doi/...
1/9
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that naked mole-rat cyclic guanosine monophosphate–adenosine ...
www.science.org
October 9, 2025 at 9:31 PM
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Naked mole rats get much older than closely related mamals of a similar size. cGAS mutations may have an important role in this.
www.science.org/doi/...
1/9
Naked mole rats get much older than closely related mamals of a similar size. cGAS mutations may have an important role in this.
www.science.org/doi/...
1/9
🧵 Excited to share that our new paper has been published in Communications Biology! Here is the link to the paper and a short thread 0/6:
Long non-coding RNAs are identified as non-invasive biomarkers predicting homologous recombination deficiency and PARP inhibitor sensitivity in high-grade serous ovarian cancer, enabling improved precision oncology approaches.
www.nature.com/articles/s42...
@kai82do.bsky.social
www.nature.com/articles/s42...
@kai82do.bsky.social
Long non-coding RNAs as a biomarker for homologous recombination deficiency and parp inhibitor sensitivity in high-grade serous ovarian cancers - Communications Biology
Long non-coding RNAs are identified as non-invasive biomarkers predicting homologous recombination deficiency and PARP inhibitor sensitivity in high-grade serous ovarian cancer, enabling improved precision oncology approaches.
www.nature.com
October 6, 2025 at 6:43 AM
🧵 Excited to share that our new paper has been published in Communications Biology! Here is the link to the paper and a short thread 0/6:
Reposted by Kai Doberstein
Long non-coding RNAs are identified as non-invasive biomarkers predicting homologous recombination deficiency and PARP inhibitor sensitivity in high-grade serous ovarian cancer, enabling improved precision oncology approaches.
www.nature.com/articles/s42...
@kai82do.bsky.social
www.nature.com/articles/s42...
@kai82do.bsky.social
Long non-coding RNAs as a biomarker for homologous recombination deficiency and parp inhibitor sensitivity in high-grade serous ovarian cancers - Communications Biology
Long non-coding RNAs are identified as non-invasive biomarkers predicting homologous recombination deficiency and PARP inhibitor sensitivity in high-grade serous ovarian cancer, enabling improved precision oncology approaches.
www.nature.com
October 3, 2025 at 10:14 AM
Long non-coding RNAs are identified as non-invasive biomarkers predicting homologous recombination deficiency and PARP inhibitor sensitivity in high-grade serous ovarian cancer, enabling improved precision oncology approaches.
www.nature.com/articles/s42...
@kai82do.bsky.social
www.nature.com/articles/s42...
@kai82do.bsky.social
Reposted by Kai Doberstein
600 Kinder verunglückt:
„Wir können nicht nach Gutdünken Tempo 30 anordnen“
WARUM NICHT?
"Außerdem sollte das Kind einen Helm tragen, gut sichtbar sein, möglichst die Radfahrprüfung absolvieren und einfach ganz, ganz vorsichtig sein"
VICTIMBLAIMING AT ITS FINEST.
#Verkehrswende #CDU #UteBonde
„Wir können nicht nach Gutdünken Tempo 30 anordnen“
WARUM NICHT?
"Außerdem sollte das Kind einen Helm tragen, gut sichtbar sein, möglichst die Radfahrprüfung absolvieren und einfach ganz, ganz vorsichtig sein"
VICTIMBLAIMING AT ITS FINEST.
#Verkehrswende #CDU #UteBonde
Berlins Verkehrssenatorin zur Schulwegsicherheit: „Wir können nicht nach Gutdünken Tempo 30 anordnen“
Ute Bonde (CDU) erklärt im Interview, wie sie Schulwege sicherer machen will. Autofreie Straßen vor Schulen wie in Frankreich betrachtet die Berliner Senatorin aber skeptisch.
www.tagesspiegel.de
September 8, 2025 at 12:55 PM
600 Kinder verunglückt:
„Wir können nicht nach Gutdünken Tempo 30 anordnen“
WARUM NICHT?
"Außerdem sollte das Kind einen Helm tragen, gut sichtbar sein, möglichst die Radfahrprüfung absolvieren und einfach ganz, ganz vorsichtig sein"
VICTIMBLAIMING AT ITS FINEST.
#Verkehrswende #CDU #UteBonde
„Wir können nicht nach Gutdünken Tempo 30 anordnen“
WARUM NICHT?
"Außerdem sollte das Kind einen Helm tragen, gut sichtbar sein, möglichst die Radfahrprüfung absolvieren und einfach ganz, ganz vorsichtig sein"
VICTIMBLAIMING AT ITS FINEST.
#Verkehrswende #CDU #UteBonde
Reposted by Kai Doberstein
Berliner Verkehrssenat: Temo 30 gestoppt, Radwegprojekte gestoppt, Kiezblocks gestoppt, Fußgängerzone gestoppt — aber jetzt den Schulkindern einreden, sie seien selbst dafür verantwortlich, wenn ihnen was passiert.
www.tagesspiegel.de/berlin/berli...
www.tagesspiegel.de/berlin/berli...
Berlins Verkehrssenatorin zu Schulwegen: „Helm tragen und ganz, ganz vorsichtig sein“
Ute Bonde (CDU) erklärt im Interview, wie sie Schulwege sicherer machen will. Autofreie Straßen vor Schulen wie in Frankreich betrachtet die Berliner Senatorin aber skeptisch.
www.tagesspiegel.de
September 8, 2025 at 5:49 AM
Berliner Verkehrssenat: Temo 30 gestoppt, Radwegprojekte gestoppt, Kiezblocks gestoppt, Fußgängerzone gestoppt — aber jetzt den Schulkindern einreden, sie seien selbst dafür verantwortlich, wenn ihnen was passiert.
www.tagesspiegel.de/berlin/berli...
www.tagesspiegel.de/berlin/berli...
Reposted by Kai Doberstein
August 27, 2025 at 4:47 PM
Reposted by Kai Doberstein
da steht man nur noch fassungslos daneben www.deutschlandfunk.de/zoll-deal-us...
Zoll-Abkommen mit Trump: Schlechter Deal fürs Klima?
Die Einigung mit US-Präsident Donald Trump bringt der EU niedrigere Zölle, aber auch eine Vervierfachung der bisherigen Importe von Kohle, Öl und Gas aus den USA. Schadet das Handelsabkommen dem EU-Kl...
www.deutschlandfunk.de
July 29, 2025 at 7:05 AM
da steht man nur noch fassungslos daneben www.deutschlandfunk.de/zoll-deal-us...
Reposted by Kai Doberstein
Let's talk about these two department store owners: brother and sister Louis Bamberger and Caroline Bamberger Fuld. From Newark, New Jersey.
They are random people, basically. But in the late 1920s, with fascism taking over Europe, they made a choice that profoundly changed the world: 🧵
They are random people, basically. But in the late 1920s, with fascism taking over Europe, they made a choice that profoundly changed the world: 🧵
May 14, 2025 at 4:41 AM
Let's talk about these two department store owners: brother and sister Louis Bamberger and Caroline Bamberger Fuld. From Newark, New Jersey.
They are random people, basically. But in the late 1920s, with fascism taking over Europe, they made a choice that profoundly changed the world: 🧵
They are random people, basically. But in the late 1920s, with fascism taking over Europe, they made a choice that profoundly changed the world: 🧵
Reposted by Kai Doberstein
Incoming - new preprint alert from the Parkes lab led by @brunobeernaert.bsky.social Full bluetutorial follows! 1/ 11 www.biorxiv.org/content/10.1...
May 12, 2025 at 12:08 PM
Incoming - new preprint alert from the Parkes lab led by @brunobeernaert.bsky.social Full bluetutorial follows! 1/ 11 www.biorxiv.org/content/10.1...
Reposted by Kai Doberstein
Bottom trawling is horribly destructive to coastal ocean ecosystems, and deep-sea mining will do the same to the open ocean. #OceanFilm 🌊
May 10, 2025 at 8:39 AM
Bottom trawling is horribly destructive to coastal ocean ecosystems, and deep-sea mining will do the same to the open ocean. #OceanFilm 🌊
Reposted by Kai Doberstein
archive.is/IJKPs
Radfahren in Mannheim
Radfahren in Mannheim
archive.is
May 6, 2025 at 7:03 PM
archive.is/IJKPs
Radfahren in Mannheim
Radfahren in Mannheim
Reposted by Kai Doberstein
On the anniversary of the sinking of the Titanic, we thought we'd answer a question that's often asked,
"If they raised the Mary Rose, why not raise the Titanic?"
Allow our scaled diagram to explain...
"If they raised the Mary Rose, why not raise the Titanic?"
Allow our scaled diagram to explain...
April 15, 2025 at 8:21 AM
On the anniversary of the sinking of the Titanic, we thought we'd answer a question that's often asked,
"If they raised the Mary Rose, why not raise the Titanic?"
Allow our scaled diagram to explain...
"If they raised the Mary Rose, why not raise the Titanic?"
Allow our scaled diagram to explain...
Reposted by Kai Doberstein
Surprising findings of BRCA mutations on the Fallopian tubes. Result of a tremendous team effort with @shenhui1986.bsky.social @vainstitute.bsky.social, Chuck Drescher @fredhutch.bsky.social, and Jarrod Marto @danafarber.bsky.social.
@pennmedcso.bsky.social
www.nature.com/articles/s41...
@pennmedcso.bsky.social
www.nature.com/articles/s41...
Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube - Nature Communications
The human Fallopian tube (FT) is implicated as a site of origin for pelvic serous cancers. Here the authors conduct multi-omics analysis on over 100 FTs. The results challenge the assumption that BRCA...
www.nature.com
March 27, 2025 at 2:29 PM
Surprising findings of BRCA mutations on the Fallopian tubes. Result of a tremendous team effort with @shenhui1986.bsky.social @vainstitute.bsky.social, Chuck Drescher @fredhutch.bsky.social, and Jarrod Marto @danafarber.bsky.social.
@pennmedcso.bsky.social
www.nature.com/articles/s41...
@pennmedcso.bsky.social
www.nature.com/articles/s41...
Reposted by Kai Doberstein
Le Monde reporting that a French scientist traveling to Houston to attend a conference was denied entry to US after a search of his phone & computer revealed messages critical of Trump's science cuts, "which [says CPB] conveyed hatred of Trump & could be qualified as terrorism". Computer confiscated
March 19, 2025 at 6:11 PM
Le Monde reporting that a French scientist traveling to Houston to attend a conference was denied entry to US after a search of his phone & computer revealed messages critical of Trump's science cuts, "which [says CPB] conveyed hatred of Trump & could be qualified as terrorism". Computer confiscated
Reposted by Kai Doberstein
Last Tuesday, I was set to give a talk on 'climate change in the Northeast' at a retirement home but had to cancel due to hourly job threats.
After nearly two weeks of overwhelming uncertainty, today it happened. I was fired from my dream of working at NOAA. I'm so sorry to everyone also affected.
After nearly two weeks of overwhelming uncertainty, today it happened. I was fired from my dream of working at NOAA. I'm so sorry to everyone also affected.
February 27, 2025 at 10:34 PM
Last Tuesday, I was set to give a talk on 'climate change in the Northeast' at a retirement home but had to cancel due to hourly job threats.
After nearly two weeks of overwhelming uncertainty, today it happened. I was fired from my dream of working at NOAA. I'm so sorry to everyone also affected.
After nearly two weeks of overwhelming uncertainty, today it happened. I was fired from my dream of working at NOAA. I'm so sorry to everyone also affected.
Reposted by Kai Doberstein
Die Macht des (Rechts-)Populismus in einem Bild.
February 24, 2025 at 11:16 AM
Die Macht des (Rechts-)Populismus in einem Bild.
Reposted by Kai Doberstein
We got a message from the university to remove any use of the "DEI", "diversity", "equity", or "inclusion" from all public-facing documents. They said that even "biodiversity" is being flagged by the federal government. We live in the dumbest timeline.
February 11, 2025 at 8:47 AM
We got a message from the university to remove any use of the "DEI", "diversity", "equity", or "inclusion" from all public-facing documents. They said that even "biodiversity" is being flagged by the federal government. We live in the dumbest timeline.
Reposted by Kai Doberstein
Fucking go birds
February 3, 2025 at 1:50 AM
Fucking go birds
Reposted by Kai Doberstein
“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
scim.ag
January 22, 2025 at 11:28 PM
“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO
Reposted by Kai Doberstein
An updated look (through 2024) at how much faster the land is warming (where we live) - this point can be obscured in the standard global mean temperature plots... 🧪⚒️
+ Data from NASA GISTEMPv4: data.giss.nasa.gov/gistemp/
+ Download graphic at: zacklabe.com/climate-chan...
+ Data from NASA GISTEMPv4: data.giss.nasa.gov/gistemp/
+ Download graphic at: zacklabe.com/climate-chan...
January 19, 2025 at 2:21 AM
An updated look (through 2024) at how much faster the land is warming (where we live) - this point can be obscured in the standard global mean temperature plots... 🧪⚒️
+ Data from NASA GISTEMPv4: data.giss.nasa.gov/gistemp/
+ Download graphic at: zacklabe.com/climate-chan...
+ Data from NASA GISTEMPv4: data.giss.nasa.gov/gistemp/
+ Download graphic at: zacklabe.com/climate-chan...
Reposted by Kai Doberstein
🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
Engineered extrachromosomal oncogene amplifications promote tumorigenesis - Nature
Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...
www.nature.com
December 18, 2024 at 4:54 PM
🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
Reposted by Kai Doberstein
The GOP messaging on modern technology is a fascinating mess. Scientific innovations in food, agriculture, and public health are part of a nefarious globalist plot to destroy you. ON the other hand, Elon Musk's rockets, AI, and crypto are noble forms of liberation via technological innovation.
RFKs plan to eliminate pesticides and genetically modified foods without viable alternatives would precipitate massive crop failures and cause global food shortages.
While it's preferable not to use gmos and pesticides, we would not be able to produce cheap grain at current scale without them.
While it's preferable not to use gmos and pesticides, we would not be able to produce cheap grain at current scale without them.
November 15, 2024 at 6:46 AM
The GOP messaging on modern technology is a fascinating mess. Scientific innovations in food, agriculture, and public health are part of a nefarious globalist plot to destroy you. ON the other hand, Elon Musk's rockets, AI, and crypto are noble forms of liberation via technological innovation.
Reposted by Kai Doberstein
Looks like there will be control groups for each and every vaccine preventable disease soon…
November 14, 2024 at 9:53 PM
Looks like there will be control groups for each and every vaccine preventable disease soon…
Reposted by Kai Doberstein
Dass ausufernde Befristung ohne Perspektiven schlecht ist, ist das eine. Dann aber auch noch die befristet Beschäftigten sowie die, die erwägen, es zu werden, mit den immer gleichen Nonsens-Argumenten zu vereimern (Verstopfung! Existenzangst macht kreativ! etc.): Gewagter Move, Freunde. #IchBinHanna
Bleibt übrigens 1 besonderes Vergnügen, sich als befristet Beschäftigte von Leuten auf unbefristeten Verträgen & mit sehr hohen Einkommen erklären zu lassen, warum Befristung ohne Perspektive 1 supertolle Sache ist. Bonus heute: 6 von 7 männl. Experten, 5 davon Profs. Wow, einfach wow. #IchBinHanna
November 13, 2024 at 6:11 PM
Dass ausufernde Befristung ohne Perspektiven schlecht ist, ist das eine. Dann aber auch noch die befristet Beschäftigten sowie die, die erwägen, es zu werden, mit den immer gleichen Nonsens-Argumenten zu vereimern (Verstopfung! Existenzangst macht kreativ! etc.): Gewagter Move, Freunde. #IchBinHanna