Melike Eren
@neurowithmelike.bsky.social
MSc. Neuroscience &MSc.Physiotherapy| Just a researcher, microglia lover |I hope to become a PhD student in neuroscience | Neuroscience, Anatomy & Exercise Physiology
Reposted by Melike Eren
Who hasn't dreamed of overcoming gravity and getting objects to hover above ground?
Physicists from the groups of Scott Waitukaitis and Carl Goodrich have developed a method to acoustically levitate objects while keeping them physically separated using charge.
Read more: ista.ac.at/en/news/scie...
Physicists from the groups of Scott Waitukaitis and Carl Goodrich have developed a method to acoustically levitate objects while keeping them physically separated using charge.
Read more: ista.ac.at/en/news/scie...
Science is Like Magic, Just Real
Physicists from the groups of Scott Waitukaitis and Carl Goodrich at the Institute of Science and Technology Austria (ISTA) have developed a method to acoustically levitate objects while keeping them ...
ista.ac.at
December 1, 2025 at 11:31 AM
Who hasn't dreamed of overcoming gravity and getting objects to hover above ground?
Physicists from the groups of Scott Waitukaitis and Carl Goodrich have developed a method to acoustically levitate objects while keeping them physically separated using charge.
Read more: ista.ac.at/en/news/scie...
Physicists from the groups of Scott Waitukaitis and Carl Goodrich have developed a method to acoustically levitate objects while keeping them physically separated using charge.
Read more: ista.ac.at/en/news/scie...
Reposted by Melike Eren
#Throwback 🧪
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
Incretin-based therapeutics for the treatment of neurodegenerative diseases - Nature Metabolism
This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease.
bit.ly
November 29, 2025 at 7:01 PM
#Throwback 🧪
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
REVIEW | Incretin-based therapeutics for the treatment of neurodegenerative diseases
@clemmensenc.bsky.social et al
It’s been a week since I finally climbed out of my reading slump, and I honestly owe it all to The Lord of the Rings. For about the seven hundredth time😅, I returned to that world, and once again, it was the one that gently pulled me back into reading😊
November 29, 2025 at 6:53 PM
It’s been a week since I finally climbed out of my reading slump, and I honestly owe it all to The Lord of the Rings. For about the seven hundredth time😅, I returned to that world, and once again, it was the one that gently pulled me back into reading😊
Reposted by Melike Eren
‘Who is the most underrated person in history? Tupaia, the Tahitian navigator and translator who enabled #JamesCook to reach Australia and New Zealand’
🎯 Patricia Fara answers some quickfire questions
buff.ly/ZQFqvYG
🎯 Patricia Fara answers some quickfire questions
buff.ly/ZQFqvYG
On the Spot: Patricia Fara
buff.ly
April 9, 2025 at 8:09 AM
‘Who is the most underrated person in history? Tupaia, the Tahitian navigator and translator who enabled #JamesCook to reach Australia and New Zealand’
🎯 Patricia Fara answers some quickfire questions
buff.ly/ZQFqvYG
🎯 Patricia Fara answers some quickfire questions
buff.ly/ZQFqvYG
Reposted by Melike Eren
New in Science!: Microglial FPR1 is a CNS-specific driver of demyelination. Deletion in MG or CNS macrophages protects against myelin loss, while peripheral deletion helps only partly. CNS-penetrant FPR1 antagonist (T0080) reduces ROS, inflammation & disease severity www.science.org/doi/10.1126/...
Targeting formyl peptide receptor 1 reduces brain inflammation and neurodegeneration
Multiple sclerosis (MS) progresses through brain region–specific inflammation and degeneration, with poorly defined mechanisms. In individuals with MS, we identified increased expression of formyl pep...
www.science.org
November 20, 2025 at 12:55 AM
New in Science!: Microglial FPR1 is a CNS-specific driver of demyelination. Deletion in MG or CNS macrophages protects against myelin loss, while peripheral deletion helps only partly. CNS-penetrant FPR1 antagonist (T0080) reduces ROS, inflammation & disease severity www.science.org/doi/10.1126/...
Reposted by Melike Eren
New study from Jiang group gives clues to Down syndrome patients' resilience to AD: a DS-linked myeloid mutation (CSF2RB A455D) protects engrafted human microglia against tau by suppressing harmful IFN signaling, boosting phagocytosis, & reducing microglial senescence www.nature.com/articles/s41...
A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease - Nature Neuroscience
Engineering human microglia with a Down-syndrome-linked myeloid gene variant resists tau-induced dysfunction and protects neurons in chimeric brains, offering proof of concept for transformative micro...
www.nature.com
November 26, 2025 at 10:16 PM
New study from Jiang group gives clues to Down syndrome patients' resilience to AD: a DS-linked myeloid mutation (CSF2RB A455D) protects engrafted human microglia against tau by suppressing harmful IFN signaling, boosting phagocytosis, & reducing microglial senescence www.nature.com/articles/s41...
Reposted by Melike Eren
What’s it like for our staff to return to #Gaza City?
Zaher and Sami, MSF nurses, were forced to flee during an Israeli offensive. Now, they’re back and recount their return to a city reduced to rubble.
Despite everything, they’ve resumed their work in two health facilities.
Zaher and Sami, MSF nurses, were forced to flee during an Israeli offensive. Now, they’re back and recount their return to a city reduced to rubble.
Despite everything, they’ve resumed their work in two health facilities.
November 27, 2025 at 2:05 PM
What’s it like for our staff to return to #Gaza City?
Zaher and Sami, MSF nurses, were forced to flee during an Israeli offensive. Now, they’re back and recount their return to a city reduced to rubble.
Despite everything, they’ve resumed their work in two health facilities.
Zaher and Sami, MSF nurses, were forced to flee during an Israeli offensive. Now, they’re back and recount their return to a city reduced to rubble.
Despite everything, they’ve resumed their work in two health facilities.
Wow 👌🏻
Open access link to new study in Nature Communications:
Topological turning points across the human lifespan.
🧪🧠 #neuroskyence
www.nature.com/articles/s41...
Topological turning points across the human lifespan.
🧪🧠 #neuroskyence
www.nature.com/articles/s41...
Topological turning points across the human lifespan - Nature Communications
Researchers discovered five phases of brain rewiring across the lifespan. The eras of childhood, adolescence, adulthood, early aging, and late aging each have characteristic rewiring of structural con...
www.nature.com
November 28, 2025 at 5:46 PM
Wow 👌🏻
Reposted by Melike Eren
Hey my first #microglia paper was featured by ASCB! This was a wild result that I first saw as a grad student and couldn’t get out of my head. Im proud of my team for getting this out into the world.
🧠 MBoC study from Benjamin Bartelle (ASU) shows that after neural injury, microglia—not invading macrophages—express Tie2. MRI + Ts-Biotag imaging reveal microglial activity over time. 🔗 www.molbiolcell.org/doi/10.1091/...
November 22, 2025 at 10:49 PM
Hey my first #microglia paper was featured by ASCB! This was a wild result that I first saw as a grad student and couldn’t get out of my head. Im proud of my team for getting this out into the world.
Reposted by Melike Eren
A 2023 Review in #ScienceTranslationalMedicine looks at the complex connections between astrocytes and other types of cells in the nervous system, including neurons, oligodendrocytes, and microglia.
Learn more: https://scim.ag/48bOKbZ #ScienceMagArchives
Learn more: https://scim.ag/48bOKbZ #ScienceMagArchives
Neuroinflammation: An astrocyte perspective
The diverse roles of astrocytes and their cell-cell interactions in neurologic diseases offer opportunities for their therapeutic targeting.
scim.ag
November 27, 2025 at 10:13 PM
A 2023 Review in #ScienceTranslationalMedicine looks at the complex connections between astrocytes and other types of cells in the nervous system, including neurons, oligodendrocytes, and microglia.
Learn more: https://scim.ag/48bOKbZ #ScienceMagArchives
Learn more: https://scim.ag/48bOKbZ #ScienceMagArchives
Reposted by Melike Eren
The presence of aberrant forms of APP is linked to #AlzheimersDisease, but its loss leads to motor deficits. This study shows that #APP supports motor coordination by regulating Na+ channels in #PurkinjeCells, expanding our understanding of APP's role in the brain @plosbiology.org 🧪 plos.io/3M1WMwL
November 26, 2025 at 5:40 PM
The presence of aberrant forms of APP is linked to #AlzheimersDisease, but its loss leads to motor deficits. This study shows that #APP supports motor coordination by regulating Na+ channels in #PurkinjeCells, expanding our understanding of APP's role in the brain @plosbiology.org 🧪 plos.io/3M1WMwL
Reposted by Melike Eren
📢 Reminder! Just a few days left to apply for the #Neurorehabilitation and Neural Repair (NNR) Early Career Editorial Program! Applications are due December 1st!
More information and details on how to apply here: www.asnr.com/files/Call_f...
#rehabilitation #careerdevelopment #neuroscience
More information and details on how to apply here: www.asnr.com/files/Call_f...
#rehabilitation #careerdevelopment #neuroscience
November 26, 2025 at 5:08 PM
📢 Reminder! Just a few days left to apply for the #Neurorehabilitation and Neural Repair (NNR) Early Career Editorial Program! Applications are due December 1st!
More information and details on how to apply here: www.asnr.com/files/Call_f...
#rehabilitation #careerdevelopment #neuroscience
More information and details on how to apply here: www.asnr.com/files/Call_f...
#rehabilitation #careerdevelopment #neuroscience
Reposted by Melike Eren
A PhD project co-supervised by Dr. Jamie Johnston is available in my lab.
This project offers a unique opportunity to pioneer the world’s first in vivo model of human neuron–microglia interactions.
To know more and apply: www.findaphd.com/phds/project...
Deadline: 07.01.2026, 5pm (UK time)
This project offers a unique opportunity to pioneer the world’s first in vivo model of human neuron–microglia interactions.
To know more and apply: www.findaphd.com/phds/project...
Deadline: 07.01.2026, 5pm (UK time)
Building the First In Vivo Model of Human Neuron–Microglia Interactions at University of Leeds on FindAPhD.com
PhD Project - Building the First In Vivo Model of Human Neuron–Microglia Interactions at University of Leeds, listed on FindAPhD.com
www.findaphd.com
November 6, 2025 at 4:38 PM
A PhD project co-supervised by Dr. Jamie Johnston is available in my lab.
This project offers a unique opportunity to pioneer the world’s first in vivo model of human neuron–microglia interactions.
To know more and apply: www.findaphd.com/phds/project...
Deadline: 07.01.2026, 5pm (UK time)
This project offers a unique opportunity to pioneer the world’s first in vivo model of human neuron–microglia interactions.
To know more and apply: www.findaphd.com/phds/project...
Deadline: 07.01.2026, 5pm (UK time)
Reposted by Melike Eren
Up to $25k in funding is available for established #neuroscience internship programs for underrepresented undergraduates in the US & Canada - covering stipends, supplies & more
Apply by 10 Jan 2026:
https://ibro.org/grant/fund-for-undergraduate-research-internship-programs/
#IBROinUSCanada
Apply by 10 Jan 2026:
https://ibro.org/grant/fund-for-undergraduate-research-internship-programs/
#IBROinUSCanada
November 18, 2025 at 6:00 AM
Up to $25k in funding is available for established #neuroscience internship programs for underrepresented undergraduates in the US & Canada - covering stipends, supplies & more
Apply by 10 Jan 2026:
https://ibro.org/grant/fund-for-undergraduate-research-internship-programs/
#IBROinUSCanada
Apply by 10 Jan 2026:
https://ibro.org/grant/fund-for-undergraduate-research-internship-programs/
#IBROinUSCanada
Reposted by Melike Eren
⚠️ Just out in @natmetabolism.nature.com ⚠️
Our latest review with @pluchinolab.bsky.social & @biancasilvalab.bsky.social explores how #microglia and #neuron #metabolism shapes #brain health and cognition! 🧠
Our Evridiki Asimakidou did a wonderful job leading this! 👏
www.nature.com/articles/s42...
Our latest review with @pluchinolab.bsky.social & @biancasilvalab.bsky.social explores how #microglia and #neuron #metabolism shapes #brain health and cognition! 🧠
Our Evridiki Asimakidou did a wonderful job leading this! 👏
www.nature.com/articles/s42...
The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism
This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.
www.nature.com
November 21, 2025 at 5:32 PM
⚠️ Just out in @natmetabolism.nature.com ⚠️
Our latest review with @pluchinolab.bsky.social & @biancasilvalab.bsky.social explores how #microglia and #neuron #metabolism shapes #brain health and cognition! 🧠
Our Evridiki Asimakidou did a wonderful job leading this! 👏
www.nature.com/articles/s42...
Our latest review with @pluchinolab.bsky.social & @biancasilvalab.bsky.social explores how #microglia and #neuron #metabolism shapes #brain health and cognition! 🧠
Our Evridiki Asimakidou did a wonderful job leading this! 👏
www.nature.com/articles/s42...
Reposted by Melike Eren
The #Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in #microglia www.nature.com/articles/s41...
The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia - Nature Neuroscience
Lecanemab, a leading therapy for Alzheimer’s disease, induces an Fc-mediated transcriptional program in human microglia, linked to osteopontin and enhanced plaque phagocytosis, suggesting alternative ...
www.nature.com
November 25, 2025 at 3:49 PM
The #Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in #microglia www.nature.com/articles/s41...
Reposted by Melike Eren
Our latest review, led by @anikavear.bsky.social with Michael Heneka, explores the emerging role of incretin-based therapies in neurodegenerative disease treatment www.nature.com/articles/s42...
Incretin-based therapeutics for the treatment of neurodegenerative diseases - Nature Metabolism
This Review summarizes preclinical and clinical evidence highlighting the potential of incretin-based drugs as treatments of neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s dise...
www.nature.com
April 14, 2025 at 9:19 AM
Our latest review, led by @anikavear.bsky.social with Michael Heneka, explores the emerging role of incretin-based therapies in neurodegenerative disease treatment www.nature.com/articles/s42...
Reposted by Melike Eren
🎉 Huge congratulations to @roisinmcmanus.bsky.social and Michael Heneka on this exciting study uncovering a novel role for NLRP3 in regulating microglial metabolism and phagocytosis to promote Alzheimer’s disease progression www.cell.com/immunity/abs...
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3
is located at mitochondria where it regulates microglial metabolism. Depletion or
chronic pharmacological inhibiti...
www.cell.com
February 6, 2025 at 8:35 PM
🎉 Huge congratulations to @roisinmcmanus.bsky.social and Michael Heneka on this exciting study uncovering a novel role for NLRP3 in regulating microglial metabolism and phagocytosis to promote Alzheimer’s disease progression www.cell.com/immunity/abs...
Reposted by Melike Eren
Neonatal hypoxic–ischaemic encephalopathy (HIE) is a leading cause of infant morbidity and mortality. Cortical subplate neurons transiently secrete a brain specific protein, neuroserpin.
We now show that exogenous neuroserpin is protective agains mild neonatal HIE (doi.org/10.3390/cell...).
We now show that exogenous neuroserpin is protective agains mild neonatal HIE (doi.org/10.3390/cell...).
November 22, 2025 at 3:11 PM
Neonatal hypoxic–ischaemic encephalopathy (HIE) is a leading cause of infant morbidity and mortality. Cortical subplate neurons transiently secrete a brain specific protein, neuroserpin.
We now show that exogenous neuroserpin is protective agains mild neonatal HIE (doi.org/10.3390/cell...).
We now show that exogenous neuroserpin is protective agains mild neonatal HIE (doi.org/10.3390/cell...).
Reposted by Melike Eren
🚨 New review out from our lab! We’re pleased to share our latest article @cp-cellreports.bsky.social exploring the airway immunometabolic response to common bacterial and viral pathogens. Shout out to @ridhimaw.bsky.social, Eric Tang and Roy Wong.
👉 Read it here: www.cell.com/cell-reports...
👉 Read it here: www.cell.com/cell-reports...
Airway immunometabolic responses during pulmonary bacterial and viral infections
Wadhwa et al. examine how respiratory bacterial and viral pathogens exploit host metabolism
to evade immune responses and influence disease outcomes. They underscore the need
for deeper insight into i...
www.cell.com
November 23, 2025 at 2:59 AM
🚨 New review out from our lab! We’re pleased to share our latest article @cp-cellreports.bsky.social exploring the airway immunometabolic response to common bacterial and viral pathogens. Shout out to @ridhimaw.bsky.social, Eric Tang and Roy Wong.
👉 Read it here: www.cell.com/cell-reports...
👉 Read it here: www.cell.com/cell-reports...
Reposted by Melike Eren
Don’t forget to sign up for the upcoming MSF Paediatric Days, held 24-25 November.
On Day 1 we will focus on paediatric care in conflict settings, addressing physical trauma and mental health.
🔗 Register today to join the conversation:
On Day 1 we will focus on paediatric care in conflict settings, addressing physical trauma and mental health.
🔗 Register today to join the conversation:
MSF Paediatric Days 2025
msf.me
November 23, 2025 at 1:23 PM
Don’t forget to sign up for the upcoming MSF Paediatric Days, held 24-25 November.
On Day 1 we will focus on paediatric care in conflict settings, addressing physical trauma and mental health.
🔗 Register today to join the conversation:
On Day 1 we will focus on paediatric care in conflict settings, addressing physical trauma and mental health.
🔗 Register today to join the conversation:
Reposted by Melike Eren
Origins of language, one of humanity’s most distinctive traits, may be best explained as a unique convergence of multiple capacities each with its own evolutionary history, involving intertwined roles of biology & culture. This framing can expand research horizons. A 🧵 on our @science.org paper.🧪1/n
What enables human language? A biocultural framework
Explaining the origins of language is a key challenge in understanding ourselves as a species. We present an empirical framework that draws on synergies across fields to facilitate robust studies of l...
www.science.org
November 23, 2025 at 11:54 AM
Origins of language, one of humanity’s most distinctive traits, may be best explained as a unique convergence of multiple capacities each with its own evolutionary history, involving intertwined roles of biology & culture. This framing can expand research horizons. A 🧵 on our @science.org paper.🧪1/n
Reposted by Melike Eren
Researchers analyzed structural & task-free functional MRI scans from patients across the #Alzheimers -frontotemporal dementia (FTD) spectrum to identify relationships between gray matter atrophy & functional connectivity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 23, 2025 at 12:03 PM
Researchers analyzed structural & task-free functional MRI scans from patients across the #Alzheimers -frontotemporal dementia (FTD) spectrum to identify relationships between gray matter atrophy & functional connectivity
www.nature.com/articles/s41...
www.nature.com/articles/s41...