Nicolas Hubacz
@nicolashubacz.bsky.social
Neuromodulation / Biotech / Healthcare / Innovation
🧬 2024 Nobel laureate David Baker has done the unthinkable — building proteins that never existed in nature.
From self-assembling nanostructures to molecular rotors, his work is turning biology into an engineering discipline.
#ProteinDesign #NobelPrize
From self-assembling nanostructures to molecular rotors, his work is turning biology into an engineering discipline.
#ProteinDesign #NobelPrize
November 12, 2025 at 4:04 PM
🧬 2024 Nobel laureate David Baker has done the unthinkable — building proteins that never existed in nature.
From self-assembling nanostructures to molecular rotors, his work is turning biology into an engineering discipline.
#ProteinDesign #NobelPrize
From self-assembling nanostructures to molecular rotors, his work is turning biology into an engineering discipline.
#ProteinDesign #NobelPrize
🧠 Microglia are the brain’s living sensors — extending and retracting their fine “feet” to shape synapses, sense activity, and repair tissue.
In this clip from Forrest Collman’s EM team, a microglia (purple) reaches across a neuron (gold), revealing the brain’s hidden choreography.
In this clip from Forrest Collman’s EM team, a microglia (purple) reaches across a neuron (gold), revealing the brain’s hidden choreography.
November 11, 2025 at 3:56 PM
🧠 Microglia are the brain’s living sensors — extending and retracting their fine “feet” to shape synapses, sense activity, and repair tissue.
In this clip from Forrest Collman’s EM team, a microglia (purple) reaches across a neuron (gold), revealing the brain’s hidden choreography.
In this clip from Forrest Collman’s EM team, a microglia (purple) reaches across a neuron (gold), revealing the brain’s hidden choreography.
🧠 MRI or monster? 👻
No filters. No effects. Just science — and it’s terrifyingly real.
These are T2-weighted MRI scans of a human head — fluid glows white, turning anatomy into nightmare fuel.
Happy Halloween from the inside out 🎃🩻
#Halloween #MRI #Neuroscience #SpookyScience
No filters. No effects. Just science — and it’s terrifyingly real.
These are T2-weighted MRI scans of a human head — fluid glows white, turning anatomy into nightmare fuel.
Happy Halloween from the inside out 🎃🩻
#Halloween #MRI #Neuroscience #SpookyScience
October 31, 2025 at 5:17 PM
🧠 MRI or monster? 👻
No filters. No effects. Just science — and it’s terrifyingly real.
These are T2-weighted MRI scans of a human head — fluid glows white, turning anatomy into nightmare fuel.
Happy Halloween from the inside out 🎃🩻
#Halloween #MRI #Neuroscience #SpookyScience
No filters. No effects. Just science — and it’s terrifyingly real.
These are T2-weighted MRI scans of a human head — fluid glows white, turning anatomy into nightmare fuel.
Happy Halloween from the inside out 🎃🩻
#Halloween #MRI #Neuroscience #SpookyScience
Our eyes are extraordinary—but evolution shaped vision in wildly different ways.
🦅 Eagles see miles away.
🐈 Cats rule the dark.
🐙 Octopuses have no blind spot.
🦐 Mantis shrimp see colors we can’t imagine.
So many ways to see—one goal: make sense of light.
#Eyes #Life #Evolution
🦅 Eagles see miles away.
🐈 Cats rule the dark.
🐙 Octopuses have no blind spot.
🦐 Mantis shrimp see colors we can’t imagine.
So many ways to see—one goal: make sense of light.
#Eyes #Life #Evolution
October 28, 2025 at 4:12 PM
Our eyes are extraordinary—but evolution shaped vision in wildly different ways.
🦅 Eagles see miles away.
🐈 Cats rule the dark.
🐙 Octopuses have no blind spot.
🦐 Mantis shrimp see colors we can’t imagine.
So many ways to see—one goal: make sense of light.
#Eyes #Life #Evolution
🦅 Eagles see miles away.
🐈 Cats rule the dark.
🐙 Octopuses have no blind spot.
🦐 Mantis shrimp see colors we can’t imagine.
So many ways to see—one goal: make sense of light.
#Eyes #Life #Evolution
A single sensory neuron grown from an induced pluripotent stem cell (iPSC), labeled for tubulin and actin to reveal its inner architecture.
🧠 This living model is used to study neurodevelopment, regeneration, and disease — how sensory pathways form, fail, and might be repaired.
#FluorescenceFriday
🧠 This living model is used to study neurodevelopment, regeneration, and disease — how sensory pathways form, fail, and might be repaired.
#FluorescenceFriday
October 24, 2025 at 3:47 PM
A single sensory neuron grown from an induced pluripotent stem cell (iPSC), labeled for tubulin and actin to reveal its inner architecture.
🧠 This living model is used to study neurodevelopment, regeneration, and disease — how sensory pathways form, fail, and might be repaired.
#FluorescenceFriday
🧠 This living model is used to study neurodevelopment, regeneration, and disease — how sensory pathways form, fail, and might be repaired.
#FluorescenceFriday
Light sheet microscopy reveals the ovary in 3D — not in slices, but as a living system.
💛 Oocytes (MVH)
💠 Blood vessels (CD31)
🧡 Granulosa cells (AMH)
A stunning look at how technology can map the architecture of fertility — where biology meets design.
💛 Oocytes (MVH)
💠 Blood vessels (CD31)
🧡 Granulosa cells (AMH)
A stunning look at how technology can map the architecture of fertility — where biology meets design.
October 23, 2025 at 4:07 PM
Light sheet microscopy reveals the ovary in 3D — not in slices, but as a living system.
💛 Oocytes (MVH)
💠 Blood vessels (CD31)
🧡 Granulosa cells (AMH)
A stunning look at how technology can map the architecture of fertility — where biology meets design.
💛 Oocytes (MVH)
💠 Blood vessels (CD31)
🧡 Granulosa cells (AMH)
A stunning look at how technology can map the architecture of fertility — where biology meets design.
The brain’s inhibitory neurons keep billions of signals in check — balancing excitation, refining rhythms, and preventing chaos.
This video shows just a glimpse of their incredible diversity.
🎥 Beauty in structure, elegance in control.
#Neuroscience
This video shows just a glimpse of their incredible diversity.
🎥 Beauty in structure, elegance in control.
#Neuroscience
October 21, 2025 at 5:09 PM
The brain’s inhibitory neurons keep billions of signals in check — balancing excitation, refining rhythms, and preventing chaos.
This video shows just a glimpse of their incredible diversity.
🎥 Beauty in structure, elegance in control.
#Neuroscience
This video shows just a glimpse of their incredible diversity.
🎥 Beauty in structure, elegance in control.
#Neuroscience
What looks like art is actually biology — a rat liver cell seen under the microscope.
Those glowing strands are actin and microtubules, the scaffolding that lets the liver filter blood, detoxify chemicals, and even regrow itself.
Credit to Dr. Francisco Lázaro-Diéguez!
#Science #Microscopy
Those glowing strands are actin and microtubules, the scaffolding that lets the liver filter blood, detoxify chemicals, and even regrow itself.
Credit to Dr. Francisco Lázaro-Diéguez!
#Science #Microscopy
October 17, 2025 at 4:08 PM
What looks like art is actually biology — a rat liver cell seen under the microscope.
Those glowing strands are actin and microtubules, the scaffolding that lets the liver filter blood, detoxify chemicals, and even regrow itself.
Credit to Dr. Francisco Lázaro-Diéguez!
#Science #Microscopy
Those glowing strands are actin and microtubules, the scaffolding that lets the liver filter blood, detoxify chemicals, and even regrow itself.
Credit to Dr. Francisco Lázaro-Diéguez!
#Science #Microscopy
Psychedelics may change not just neurons, but neurovascular coupling—the link between brain activity and blood flow.
That means some fMRI “network effects” could be vascular. Multimodal imaging is key.
#neuroscience #fMRI #psychedelics #serotonin
That means some fMRI “network effects” could be vascular. Multimodal imaging is key.
#neuroscience #fMRI #psychedelics #serotonin
October 13, 2025 at 9:20 PM
Psychedelics may change not just neurons, but neurovascular coupling—the link between brain activity and blood flow.
That means some fMRI “network effects” could be vascular. Multimodal imaging is key.
#neuroscience #fMRI #psychedelics #serotonin
That means some fMRI “network effects” could be vascular. Multimodal imaging is key.
#neuroscience #fMRI #psychedelics #serotonin
🧠 The cerebellum — 10% of brain volume, 50% of its neurons.'
A dense web of circuits predicting and correcting our every move, thought, and emotion.
The brain’s most precise learning machine sits quietly at its back.
Credit Greg Dunn!
#Neuroscience #Cerebellum #BrainScience
A dense web of circuits predicting and correcting our every move, thought, and emotion.
The brain’s most precise learning machine sits quietly at its back.
Credit Greg Dunn!
#Neuroscience #Cerebellum #BrainScience
October 7, 2025 at 4:56 PM
🧠 The cerebellum — 10% of brain volume, 50% of its neurons.'
A dense web of circuits predicting and correcting our every move, thought, and emotion.
The brain’s most precise learning machine sits quietly at its back.
Credit Greg Dunn!
#Neuroscience #Cerebellum #BrainScience
A dense web of circuits predicting and correcting our every move, thought, and emotion.
The brain’s most precise learning machine sits quietly at its back.
Credit Greg Dunn!
#Neuroscience #Cerebellum #BrainScience
🎨 Creative practice reshapes the brain.
EEG/MEG data (N=1,472) show artists, dancers, musicians & gamers have brains 5–7 yrs younger than non-experts.
Even 30 hrs of learning slowed brain aging by boosting connectivity & efficiency.
#Neuroscience #Creativity #BrainHealth
EEG/MEG data (N=1,472) show artists, dancers, musicians & gamers have brains 5–7 yrs younger than non-experts.
Even 30 hrs of learning slowed brain aging by boosting connectivity & efficiency.
#Neuroscience #Creativity #BrainHealth
October 6, 2025 at 4:53 PM
🎨 Creative practice reshapes the brain.
EEG/MEG data (N=1,472) show artists, dancers, musicians & gamers have brains 5–7 yrs younger than non-experts.
Even 30 hrs of learning slowed brain aging by boosting connectivity & efficiency.
#Neuroscience #Creativity #BrainHealth
EEG/MEG data (N=1,472) show artists, dancers, musicians & gamers have brains 5–7 yrs younger than non-experts.
Even 30 hrs of learning slowed brain aging by boosting connectivity & efficiency.
#Neuroscience #Creativity #BrainHealth
What you’re seeing is self-pollination in action 🌸
This thymeleaf speedwell (Veronica serpyllifolia) doesn’t wait for bees or wind — it transfers its own pollen to ensure survival. A quiet but powerful strategy in uncertain environments.
This thymeleaf speedwell (Veronica serpyllifolia) doesn’t wait for bees or wind — it transfers its own pollen to ensure survival. A quiet but powerful strategy in uncertain environments.
October 3, 2025 at 9:30 PM
What you’re seeing is self-pollination in action 🌸
This thymeleaf speedwell (Veronica serpyllifolia) doesn’t wait for bees or wind — it transfers its own pollen to ensure survival. A quiet but powerful strategy in uncertain environments.
This thymeleaf speedwell (Veronica serpyllifolia) doesn’t wait for bees or wind — it transfers its own pollen to ensure survival. A quiet but powerful strategy in uncertain environments.
This sea star is only 2 months old 🐣 — but already has a decentralized nervous system. No brain, just a nerve ring + radial cords guiding how it moves, senses & grows.
🌊 Echinoderm family
🧠 Brain-free coordination
🔄 Decentralized = resilient
Credit: Dr. Laurent Formery
#Neurobiology #Science
🌊 Echinoderm family
🧠 Brain-free coordination
🔄 Decentralized = resilient
Credit: Dr. Laurent Formery
#Neurobiology #Science
September 26, 2025 at 7:47 PM
This sea star is only 2 months old 🐣 — but already has a decentralized nervous system. No brain, just a nerve ring + radial cords guiding how it moves, senses & grows.
🌊 Echinoderm family
🧠 Brain-free coordination
🔄 Decentralized = resilient
Credit: Dr. Laurent Formery
#Neurobiology #Science
🌊 Echinoderm family
🧠 Brain-free coordination
🔄 Decentralized = resilient
Credit: Dr. Laurent Formery
#Neurobiology #Science
Watch mouse brain tumor cells in action 🧠
Actin (purple) gives them structure & movement, while mitochondria (green) supply the energy for growth.
Visualizing these systems helps scientists decode how tumors spread — and how we might disrupt them.
#BrainTumors #Neuroscience #Microscopy
Actin (purple) gives them structure & movement, while mitochondria (green) supply the energy for growth.
Visualizing these systems helps scientists decode how tumors spread — and how we might disrupt them.
#BrainTumors #Neuroscience #Microscopy
September 25, 2025 at 4:52 PM
Watch mouse brain tumor cells in action 🧠
Actin (purple) gives them structure & movement, while mitochondria (green) supply the energy for growth.
Visualizing these systems helps scientists decode how tumors spread — and how we might disrupt them.
#BrainTumors #Neuroscience #Microscopy
Actin (purple) gives them structure & movement, while mitochondria (green) supply the energy for growth.
Visualizing these systems helps scientists decode how tumors spread — and how we might disrupt them.
#BrainTumors #Neuroscience #Microscopy
The cerebral cortex powers higher cognition through four lobes:
🚀 Frontal – executive control & motor output
📐 Parietal – sensory integration & spatial awareness
🎶 Temporal – memory, language & emotion
👁️ Occipital – vision & recognition
#Neuroscience #Brain #Cognition
🚀 Frontal – executive control & motor output
📐 Parietal – sensory integration & spatial awareness
🎶 Temporal – memory, language & emotion
👁️ Occipital – vision & recognition
#Neuroscience #Brain #Cognition
September 22, 2025 at 4:32 PM
The cerebral cortex powers higher cognition through four lobes:
🚀 Frontal – executive control & motor output
📐 Parietal – sensory integration & spatial awareness
🎶 Temporal – memory, language & emotion
👁️ Occipital – vision & recognition
#Neuroscience #Brain #Cognition
🚀 Frontal – executive control & motor output
📐 Parietal – sensory integration & spatial awareness
🎶 Temporal – memory, language & emotion
👁️ Occipital – vision & recognition
#Neuroscience #Brain #Cognition
🧠 In Alzheimer’s, brain activity becomes less complex.
Dr. Kay Jann’s team showed this drop in complexity links to tau buildup & cognitive declineseen in both typical & genetic AD.
Measuring complexity could help detect AD earlier & track its progression.
📽️ Video credit: Dr. Kay Jann & colleagues
Dr. Kay Jann’s team showed this drop in complexity links to tau buildup & cognitive declineseen in both typical & genetic AD.
Measuring complexity could help detect AD earlier & track its progression.
📽️ Video credit: Dr. Kay Jann & colleagues
September 19, 2025 at 5:58 PM
🧠 In Alzheimer’s, brain activity becomes less complex.
Dr. Kay Jann’s team showed this drop in complexity links to tau buildup & cognitive declineseen in both typical & genetic AD.
Measuring complexity could help detect AD earlier & track its progression.
📽️ Video credit: Dr. Kay Jann & colleagues
Dr. Kay Jann’s team showed this drop in complexity links to tau buildup & cognitive declineseen in both typical & genetic AD.
Measuring complexity could help detect AD earlier & track its progression.
📽️ Video credit: Dr. Kay Jann & colleagues
🧠 The Parietal Cortex
Integrates sensory input for spatial mapping, body awareness, math & logic. Critical for navigation, perception, and coordinated action.
Damage can cause neglect or Gerstmann’s Syndrome.
Credit: Greg A Dunn
#Neuroscience #CognitiveScience #ParietalCortex
Integrates sensory input for spatial mapping, body awareness, math & logic. Critical for navigation, perception, and coordinated action.
Damage can cause neglect or Gerstmann’s Syndrome.
Credit: Greg A Dunn
#Neuroscience #CognitiveScience #ParietalCortex
September 18, 2025 at 4:48 PM
🧠 The Parietal Cortex
Integrates sensory input for spatial mapping, body awareness, math & logic. Critical for navigation, perception, and coordinated action.
Damage can cause neglect or Gerstmann’s Syndrome.
Credit: Greg A Dunn
#Neuroscience #CognitiveScience #ParietalCortex
Integrates sensory input for spatial mapping, body awareness, math & logic. Critical for navigation, perception, and coordinated action.
Damage can cause neglect or Gerstmann’s Syndrome.
Credit: Greg A Dunn
#Neuroscience #CognitiveScience #ParietalCortex
🌎 The World of Migrasomes 🌎
Migrasomes, pomegranate-like organelles formed by migrating cells, play key roles in signaling, mitochondrial quality control, and lateral transfer of mRNA/proteins.
A brand-new frontier in cell biology!
Credit: NIH & Lilian Chen
Migrasomes, pomegranate-like organelles formed by migrating cells, play key roles in signaling, mitochondrial quality control, and lateral transfer of mRNA/proteins.
A brand-new frontier in cell biology!
Credit: NIH & Lilian Chen
September 17, 2025 at 3:55 PM
🌎 The World of Migrasomes 🌎
Migrasomes, pomegranate-like organelles formed by migrating cells, play key roles in signaling, mitochondrial quality control, and lateral transfer of mRNA/proteins.
A brand-new frontier in cell biology!
Credit: NIH & Lilian Chen
Migrasomes, pomegranate-like organelles formed by migrating cells, play key roles in signaling, mitochondrial quality control, and lateral transfer of mRNA/proteins.
A brand-new frontier in cell biology!
Credit: NIH & Lilian Chen
The Highest Resolution MRI EVER 🧠
The first 7T scans reveal brain microstructures in stunning detail — and next up is an 11.7T, $81M scanner. This leap will transform neuroscience, from mapping networks to tackling disease.
Credit: French CEA
#Neuroscience #MRI
The first 7T scans reveal brain microstructures in stunning detail — and next up is an 11.7T, $81M scanner. This leap will transform neuroscience, from mapping networks to tackling disease.
Credit: French CEA
#Neuroscience #MRI
September 16, 2025 at 5:06 PM
The Highest Resolution MRI EVER 🧠
The first 7T scans reveal brain microstructures in stunning detail — and next up is an 11.7T, $81M scanner. This leap will transform neuroscience, from mapping networks to tackling disease.
Credit: French CEA
#Neuroscience #MRI
The first 7T scans reveal brain microstructures in stunning detail — and next up is an 11.7T, $81M scanner. This leap will transform neuroscience, from mapping networks to tackling disease.
Credit: French CEA
#Neuroscience #MRI
Hypersensitivity Reactions 🌼
🌸 Type I – IgE & mast cells → allergies, asthma
🩸 Type II – IgG vs. cells → hemolytic anemia
⚖️ Type III – Immune complexes → serum sickness
🔥 Type IV – T-cells → dermatitis, TB test
Knowing the mechanism helps guide treatment.
Credit: DiPiro JT, Talbert RL, et al.
🌸 Type I – IgE & mast cells → allergies, asthma
🩸 Type II – IgG vs. cells → hemolytic anemia
⚖️ Type III – Immune complexes → serum sickness
🔥 Type IV – T-cells → dermatitis, TB test
Knowing the mechanism helps guide treatment.
Credit: DiPiro JT, Talbert RL, et al.
September 15, 2025 at 11:21 PM
Hypersensitivity Reactions 🌼
🌸 Type I – IgE & mast cells → allergies, asthma
🩸 Type II – IgG vs. cells → hemolytic anemia
⚖️ Type III – Immune complexes → serum sickness
🔥 Type IV – T-cells → dermatitis, TB test
Knowing the mechanism helps guide treatment.
Credit: DiPiro JT, Talbert RL, et al.
🌸 Type I – IgE & mast cells → allergies, asthma
🩸 Type II – IgG vs. cells → hemolytic anemia
⚖️ Type III – Immune complexes → serum sickness
🔥 Type IV – T-cells → dermatitis, TB test
Knowing the mechanism helps guide treatment.
Credit: DiPiro JT, Talbert RL, et al.
🩻 Capturing the Cytoskeleton of Mesenchymal Cells
⚪ Microtubules (grey)
🔵 Actin filaments (blue)
🟣 Nuclei (magenta)
Credit: Image to Micaela Lasser and Helen Willsey for the great work getting this image!
⚪ Microtubules (grey)
🔵 Actin filaments (blue)
🟣 Nuclei (magenta)
Credit: Image to Micaela Lasser and Helen Willsey for the great work getting this image!
September 12, 2025 at 3:32 PM
🩻 Capturing the Cytoskeleton of Mesenchymal Cells
⚪ Microtubules (grey)
🔵 Actin filaments (blue)
🟣 Nuclei (magenta)
Credit: Image to Micaela Lasser and Helen Willsey for the great work getting this image!
⚪ Microtubules (grey)
🔵 Actin filaments (blue)
🟣 Nuclei (magenta)
Credit: Image to Micaela Lasser and Helen Willsey for the great work getting this image!
Digestion & Absorption 🏋️ From stomach to colon, each organ plays a role:
🍲 Stomach → proteins, B12, iron
🟢 Liver/Gallbladder → bile for fats
🔶 Pancreas → enzymes
📍 Small intestine → most nutrients
💧 Colon → water + electrolytes
🍲 Stomach → proteins, B12, iron
🟢 Liver/Gallbladder → bile for fats
🔶 Pancreas → enzymes
📍 Small intestine → most nutrients
💧 Colon → water + electrolytes
September 8, 2025 at 5:41 PM
Digestion & Absorption 🏋️ From stomach to colon, each organ plays a role:
🍲 Stomach → proteins, B12, iron
🟢 Liver/Gallbladder → bile for fats
🔶 Pancreas → enzymes
📍 Small intestine → most nutrients
💧 Colon → water + electrolytes
🍲 Stomach → proteins, B12, iron
🟢 Liver/Gallbladder → bile for fats
🔶 Pancreas → enzymes
📍 Small intestine → most nutrients
💧 Colon → water + electrolytes
What Happens During Cell Death 🦠
Under oxidative stress, the cell releases apoptotic vesicles—tiny packages carrying signals that guide immune cleanup and tissue repair.
Captured with MOSAIC lattice light sheet, this shows how even a cell’s “last act” shapes health and disease.
Credit Eric Betzi
Under oxidative stress, the cell releases apoptotic vesicles—tiny packages carrying signals that guide immune cleanup and tissue repair.
Captured with MOSAIC lattice light sheet, this shows how even a cell’s “last act” shapes health and disease.
Credit Eric Betzi
September 3, 2025 at 5:25 PM
What Happens During Cell Death 🦠
Under oxidative stress, the cell releases apoptotic vesicles—tiny packages carrying signals that guide immune cleanup and tissue repair.
Captured with MOSAIC lattice light sheet, this shows how even a cell’s “last act” shapes health and disease.
Credit Eric Betzi
Under oxidative stress, the cell releases apoptotic vesicles—tiny packages carrying signals that guide immune cleanup and tissue repair.
Captured with MOSAIC lattice light sheet, this shows how even a cell’s “last act” shapes health and disease.
Credit Eric Betzi
🍏 Vitamin Cheat Sheet 💊
Vitamins are the unsung heroes of our daily health, quietly powering vital processes like energy conversion, cell repair, and immune defense.
This vibrant cheat sheet simplifies the science, pairing each vitamin with its key benefits and natural sources.
#Vitamins
Vitamins are the unsung heroes of our daily health, quietly powering vital processes like energy conversion, cell repair, and immune defense.
This vibrant cheat sheet simplifies the science, pairing each vitamin with its key benefits and natural sources.
#Vitamins
November 19, 2024 at 2:29 AM
🍏 Vitamin Cheat Sheet 💊
Vitamins are the unsung heroes of our daily health, quietly powering vital processes like energy conversion, cell repair, and immune defense.
This vibrant cheat sheet simplifies the science, pairing each vitamin with its key benefits and natural sources.
#Vitamins
Vitamins are the unsung heroes of our daily health, quietly powering vital processes like energy conversion, cell repair, and immune defense.
This vibrant cheat sheet simplifies the science, pairing each vitamin with its key benefits and natural sources.
#Vitamins