Rahel Woldeyes
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rahelwoldeyes.bsky.social
Rahel Woldeyes
@rahelwoldeyes.bsky.social
1.6K followers 900 following 15 posts
A Structural systems/cell biologist #teamtomo #cryoET #cryoem

https://orcid.org/0000-0003-0737-8383
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rahelwoldeyes.bsky.social
Rahel Woldeyes @rahelwoldeyes.bsky.social · Oct 27
Very excited to share our paper. www.biorxiv.org/content/10.1...
We combine cutting-edge developments in cryo-electron tomography with hiPSC-cardiomyocytes to visualize cardiac proteins in their cellular context in health and disease.  #cryoem #teamtomo #cryoet 🧵
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Reposted by Rahel Woldeyes
raulpadron.bsky.social
October 5, 2025 at 2:56 PM
Reposted by Rahel Woldeyes
edwardteng.bsky.social
Muyuan Chen has turned structural biology into an immersive experience with his new video game Meowtabolism, now available on Steam.
Try the demo here: store.steampowered.com/app/4045010/...
Give Muyuan feedback: steamcommunity.com/app/4045010
#ScienceGaming #StructuralBiology #CryoEM #STEMOutreach
October 4, 2025 at 1:34 PM
Reposted by Rahel Woldeyes
biorxivpreprint.bsky.social
Correlative MS Imaging for cellular identification and analysis of in situ cryo-ET https://www.biorxiv.org/content/10.1101/2025.09.16.676641v1
September 19, 2025 at 2:49 AM
Reposted by Rahel Woldeyes
sbgrid.bsky.social
New Title Alert: DenoisET- an implementation of the Noise2Noise algorithm specifically designed for cryoET data denoising.

Learn more here: buff.ly/8i8i87U

#SBGrid #SBGridSoftware #StructualBiology
GitHub - apeck12/denoiset: An implementation of Noise2Noise for cryoET data
An implementation of Noise2Noise for cryoET data. Contribute to apeck12/denoiset development by creating an account on GitHub.
buff.ly
August 14, 2025 at 4:14 PM
Reposted by Rahel Woldeyes
brittanytrang.com
NEW from me at STAT:

We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's #AlphaFold to prominence (and a Nobel Prize), as its NIH funding runs out.

More @statnews.com:
www.statnews.com/2025/07/21/c...

🖥️🩺🧪🧬 #bioML
AlphaFold developer Google DeepMind to fund CASP as NIH funding falls short
Protein structure prediction contest CASP gets temporary funding from Google DeepMind as NIH grant runs out.
www.statnews.com
July 21, 2025 at 4:40 PM
Reposted by Rahel Woldeyes
anthonyshiver.bsky.social
A future perspective article on the next 10 years in microbial molecular biology and physiology is online now.
journals.asm.org/doi/10.1128/... 🧵👇
An exciting future for microbial molecular biology and physiology | mBio
The first two bacterial genomes were sequenced nearly 30 years ago (1, 2). The cost of one of those sequences, that of Haemophilus influenzae, was over 1,000,000 U.S. dollars and took multiple years (...
journals.asm.org
July 2, 2025 at 10:02 PM
rahelwoldeyes.bsky.social
www.nature.com/articles/d41... #heartmusclecells :)
Can AI build a virtual cell? Scientists race to model life’s smallest unit
Several groups hope to develop artificial-intelligence models that can predict how cells behave.
www.nature.com
June 28, 2025 at 8:52 PM
Reposted by Rahel Woldeyes
marcusabrubaker.bsky.social
Ever wonder why SGD, which works so well for ab initio cryo-EM, never seems to get to high resolution on its own? Well, we have the answer: conditioning!
btoader.com Bogdan Toader @btoader.com · Jun 24
Work on SGD for high-resolution cryo-EM refinement from my previous postdoc finally published in @actacrystd.iucr.org

with Roy Lederman and @marcusabrubaker.bsky.social

📜 Paper: journals.iucr.org/paper?S20597...
💻 Code: github.com/bogdantoader...
💾 Data: doi.org/10.5281/zeno...
June 24, 2025 at 9:31 PM
Reposted by Rahel Woldeyes
erc.europa.eu
🎉 Congratulations to Wolfgang Baumeister @maxplanck.de, awarded the 2025 #ShawPrize in Life Science & Medicine for pioneering work in cryo-ET!

Learn more 👉 europa.eu/!JBXDBG
#FrontierResearch #ERCSyG #CryoET #StructuralBiology #shawprize2025
ERC grantee wins the Shaw Prize in Life Science and Medicine
2025 Shaw Prize honours ERC-funded research in molecular imaging
europa.eu
May 28, 2025 at 7:49 AM
Reposted by Rahel Woldeyes
ritastrack.bsky.social
I was awestruck by the work I saw presented at the CZI Imaging Institute today. They are pursuing difficult problems head on with great ideas and the right people, and it's paying off in progress. In situ structural biology is going to be a solved problem. A million thanks to my host Shawn Zheng.
May 20, 2025 at 3:38 AM
Reposted by Rahel Woldeyes
danielhurdiss.bsky.social
I’m delighted that we could contribute the #cryoEM data to this incredible antiviral discovery project from the group of @neytsjohan.bsky.social 💊

"A coronavirus assembly inhibitor that targets the viral membrane protein"

www.nature.com/articles/s41...

A huge congrats to everyone involved! 🎉
March 26, 2025 at 4:31 PM
Reposted by Rahel Woldeyes
profbilc.bsky.social
A new paper from our lab is available at doi.org/10.1101/2025.... The work describes how ArsA, which is involved in arsenic detoxification, utilizes nucleotides to drive dramatic conformational changes—multiple EM structures of a 64kDa protein. Congratulations to Shivansh Mahajan.
Nucleotide and metalloid-driven conformational changes in the arsenite efflux ATPase ArsA
A common mechanism of arsenic detoxification in bacteria is arsenite (AsIII) efflux facilitated by the ArsAB pump that couples metalloid transport to ATP hydrolysis. The cytoplasmic ATPase component, ...
doi.org
March 25, 2025 at 9:00 PM
Reposted by Rahel Woldeyes
stanfordcvi.bsky.social
The Mechanisms and Innovations in Cardiovascular Disease T32 Training Grant is currently recruiting PhD and MD scientists to join its postdoctoral training fellowship.

To apply, please follow this link: stanforduniversity.qualtrics.com/jfe/form/SV_....
March 25, 2025 at 5:41 PM
Reposted by Rahel Woldeyes
cryoempapers.bsky.social
AreTomoLive: Automated reconstruction of comprehensively-corrected and denoised cryo-electron tomograms in real-time and at high throughput www.biorxiv.org/content/10.1101/2025.03.11.642690v1 #cryoem
March 14, 2025 at 7:10 AM
rahelwoldeyes.bsky.social
www.biorxiv.org/content/10.1... #teamtomo #cryoET
Structure of the Thin Filament in Human iPSC-derived Cardiomyocytes and its Response to Heart Disease
Cardiovascular diseases are a leading cause of death worldwide, but our understanding of the underlying mechanisms is limited, in part because of the complexity of the cellular machinery that controls...
www.biorxiv.org
February 27, 2025 at 6:51 AM
Reposted by Rahel Woldeyes
christlet.bsky.social
Notre Dame is so back
February 26, 2025 at 1:20 PM
Reposted by Rahel Woldeyes
randyjread.bsky.social
Watch out for an upcoming bluetorial/tweetorial on this work from the amazing @alisiafadini.bsky.social!

www.biorxiv.org/content/10.1...
AlphaFold as a Prior: Experimental Structure Determination Conditioned on a Pretrained Neural Network
Advances in machine learning have transformed structural biology, enabling swift and accurate prediction of protein structure from sequence. However, challenges persist in capturing sidechain packing,...
www.biorxiv.org
February 22, 2025 at 8:50 AM
rahelwoldeyes.bsky.social
www6.slac.stanford.edu/news/2025-02...
Innovative target design leads to surprising discovery in laser-plasma acceleration
Scientists studying laser-plasma proton acceleration made an unexpected breakthrough, simultaneously resolving multiple long-standing problems although they had only aimed to address one.
www6.slac.stanford.edu
February 18, 2025 at 5:22 PM
Reposted by Rahel Woldeyes
alushinlab.bsky.social
My heart goes out to all my NIH people. Unbelievable.
February 14, 2025 at 11:59 PM
Reposted by Rahel Woldeyes
srikosuri.bsky.social
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
Reposted by Rahel Woldeyes
lab-scita.bsky.social
Deeply saddened by the passing of Prof. Mike Sheetz, a true leader in Mechanobiology. His groundbreaking work on Kinesin, membrane organization, and mechanotransduction has left an indelible mark. A tremendous loss to science. #Mechanobiology #Science #LaskerAward
February 1, 2025 at 11:29 AM
Reposted by Rahel Woldeyes
jeremymberg.bsky.social
A special Bluetorial about one of my mentors Ruth Kirschstein

Among Ruth Kirschstein’s many contributions to American science was the development and expansion of programs intended to increase participation of people from groups underrepresented in biomedical research.
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
January 31, 2025 at 2:48 PM
Reposted by Rahel Woldeyes
bjorkman-lab.bsky.social
@caltech.edu asked Dr. Pamela Bjorkman "if overusing antibiotics can be harmful. Should we worry about overusing vaccines too?" The short answer is no.
Swipe to learn more from Caltech's Pamela Bjorkman.
#AskCaltech at caltech.edu/AskCaltech. 1/2
January 27, 2025 at 1:52 AM
Reposted by Rahel Woldeyes
jeremymberg.bsky.social
Let me give a concrete example of the importance of applications with high risk-high reward as well as the role of NIH staff in taking risks.

Decades ago, a physical chemist proposed ideas about doing mass spectrometry on proteins (when this was deemed probably impossible).

1/n
January 26, 2025 at 9:51 PM