Raúl Padrón
@raulpadron.bsky.social
Structural Biologist
Curiosity driven research rules!
Myosin interacting-heads motif (IHM) ->
Thick filaments -> Muscle -> Movement!
Padrón-Craig Lab
Umass Chan Medical School, Worcester, Massachusetts, U.S.A
Curiosity driven research rules!
Myosin interacting-heads motif (IHM) ->
Thick filaments -> Muscle -> Movement!
Padrón-Craig Lab
Umass Chan Medical School, Worcester, Massachusetts, U.S.A
QuickStainer: a rapid negative staining device for improved preservation of molecular structure www.biorxiv.org/content/10.1101/2025.10.11.681814v1 #cryoem
October 14, 2025 at 10:56 PM
Thick filament molecular interfaces play a critical role in pathogenesis of hypertrophic and dilated cardiomyopathy
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Thick filament molecular interfaces play a critical role in pathogenesis of hypertrophic and dilated cardiomyopathy
Hypertrophic (HCM) and dilated (DCM) cardiomyopathy variants in genes encoding the myosin heavy chain (MYH7), myosin light chains (MYL2 and MYL3), and cardiac myosin binding protein-C (cMyBP-C, MYBPC3...
www.biorxiv.org
October 5, 2025 at 2:56 PM
Reposted by Raúl Padrón
Annotating the X-ray diffraction pattern of vertebrate striated muscle www.biorxiv.org/content/10.1101/2025.06.11.659175v1 #cryoem
June 17, 2025 at 9:16 AM
Annotating the X-ray diffraction pattern of vertebrate striated muscle www.biorxiv.org/content/10.1101/2025.06.11.659175v1 #cryoem
Reposted by Raúl Padrón
Proteins operate on a short timescale — on the order of a millisecond, or even faster
https://go.nature.com/4l7qAEm
https://go.nature.com/4l7qAEm
Freeze frame: cracking molecular motion
Time-resolved cryo-electron microscopy can resolve protein motion on millisecond or even microsecond timescales, but the need for highly specialized tools and skills limits the method’s reach.
go.nature.com
June 16, 2025 at 10:22 AM
Proteins operate on a short timescale — on the order of a millisecond, or even faster
https://go.nature.com/4l7qAEm
https://go.nature.com/4l7qAEm
Reposted by Raúl Padrón
Interested in how the heart generates contractile forces to pump blood? Then take a look at our new paper "α- and β-myosin II can be non-uniformly distributed within the cardiac sarcomere". #CellBiology
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
March 31, 2025 at 4:40 PM
Interested in how the heart generates contractile forces to pump blood? Then take a look at our new paper "α- and β-myosin II can be non-uniformly distributed within the cardiac sarcomere". #CellBiology
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Trump Administration Has Begun a War on Science, Researchers Say www.nytimes.com/2025/03/31/s...
Trump Administration Has Begun a War on Science, Researchers Say
Nearly 2,000 scientists urged that Congress restore funding to federal agencies decimated by recent cuts.
www.nytimes.com
March 31, 2025 at 8:05 PM
Trump Administration Has Begun a War on Science, Researchers Say www.nytimes.com/2025/03/31/s...
Reposted by Raúl Padrón
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
Action Intent Links | Bluesky
Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...
docs.bsky.app
November 18, 2024 at 2:48 PM
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
Reposted by Raúl Padrón
Working hard this weekend at the P03 beamline, PetraIII synchrotron, DESY, Hamburg. Really amazing multi-national team uncovering the secrets of the heart! @droch.bsky.social @edgarnollet.bsky.social @ambiotech.us
November 24, 2024 at 10:11 AM
Working hard this weekend at the P03 beamline, PetraIII synchrotron, DESY, Hamburg. Really amazing multi-national team uncovering the secrets of the heart! @droch.bsky.social @edgarnollet.bsky.social @ambiotech.us
Reposted by Raúl Padrón
I am trying to gauge how much interest is given to muscle wasting in critical illness within the scientific community? This is a very heterogenous condition and would be keen on join forces to further understand it!!!
January 3, 2025 at 4:58 PM
I am trying to gauge how much interest is given to muscle wasting in critical illness within the scientific community? This is a very heterogenous condition and would be keen on join forces to further understand it!!!
Reposted by Raúl Padrón
A really nice special issue in @jphysiol.bsky.social by Dr. Chris Sundberg “Physiology of ageing skeletal muscle and the protective effects of exercise” feat. some work by our lab and many others! Check it out @myoblue.bsky.social physoc.onlinelibrary.wiley.com/toc/14697793...
Special Issue: Physiology of ageing skeletal muscle and the protective effects of exercise: The Journal of Physiology: Vol 603, No 1
<em>The Journal of Physiology</em> publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.
physoc.onlinelibrary.wiley.com
January 6, 2025 at 7:44 PM
A really nice special issue in @jphysiol.bsky.social by Dr. Chris Sundberg “Physiology of ageing skeletal muscle and the protective effects of exercise” feat. some work by our lab and many others! Check it out @myoblue.bsky.social physoc.onlinelibrary.wiley.com/toc/14697793...
Reposted by Raúl Padrón
Excited to be part of a consortium application to the European Rare Disease Research Alliance (ERDERA), lead by Coen Ottenheijm (NL). Among the group, I point out @droch.bsky.social, as we seem to be finding ourselves more and more on the same applications. Our methods really pair well together!
February 13, 2025 at 4:28 PM
Excited to be part of a consortium application to the European Rare Disease Research Alliance (ERDERA), lead by Coen Ottenheijm (NL). Among the group, I point out @droch.bsky.social, as we seem to be finding ourselves more and more on the same applications. Our methods really pair well together!
Reposted by Raúl Padrón
Good overview of our recent paper: Hearts of hibernating bears use less energy
Hearts of hibernating bears use less energy
Forskere har identificeret, hvad der helt præcist sker i hjertet hos bjørne, når de går i hi. Opdagelserne kan lede til udvikling af bedre hjertemedicin til patienter med hjertesvigt, siger en...
sciencenews.dk
February 25, 2025 at 7:32 AM
Good overview of our recent paper: Hearts of hibernating bears use less energy
Reposted by Raúl Padrón
In this Q&A with #NobelPrize recipient Victor R. Ambros, PhD, writer Patrick Boyle comments, “While the science behind the discovery of #microRNA is remarkable, also remarkable is what the discovery illustrates about the importance of basic science research.” direc.to/mEkL @aamctoday.bsky.social
Nobel laureate: Basic science research is critical for medical progress
Victor Ambros, PhD, co-winner of the 2024 prize in medicine, says public support and scientific fellowship fueled discovery of an RNA that regulates genes.
direc.to
March 16, 2025 at 9:41 PM
In this Q&A with #NobelPrize recipient Victor R. Ambros, PhD, writer Patrick Boyle comments, “While the science behind the discovery of #microRNA is remarkable, also remarkable is what the discovery illustrates about the importance of basic science research.” direc.to/mEkL @aamctoday.bsky.social