Author | Lightnews

Reposted by Cheryl.Batchelor

Cheryl.Batchelor @sunshineandtruth.bsky.social · 3h

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Cheryl.Batchelor @sunshineandtruth.bsky.social · 3h

1

Reposted by Cheryl.Batchelor

Cheryl.Batchelor @sunshineandtruth.bsky.social · 3h

🧩 Bottom Line

Leucovorin is not a cure for autism, but research suggests it may help certain subgroups, especially those with folate transport issues or FRAA positivity. It should be used only under medical supervision after appropriate testing.

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Cheryl.Batchelor @sunshineandtruth.bsky.social · 3h

🧩 Bottom Line

Leucovorin is not a cure for autism, but research suggests it may help certain subgroups, especially those with folate transport issues or FRAA positivity. It should be used only under medical supervision after appropriate testing.

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Reposted by Cheryl.Batchelor

Cheryl.Batchelor @sunshineandtruth.bsky.social · 3h

Safety:
• Generally well tolerated.
• Possible side effects include irritability, insomnia, or mild gastrointestinal upset in some children.
• Usually given under medical supervision and often with monitoring of FRAA status, folate metabolism markers, and sometimes mitochondrial function.

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Cheryl.Batchelor @sunshineandtruth.bsky.social · 3h

Safety:
• Generally well tolerated.
• Possible side effects include irritability, insomnia, or mild gastrointestinal upset in some children.
• Usually given under medical supervision and often with monitoring of FRAA status, folate metabolism markers, and sometimes mitochondrial function.

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Reposted by Cheryl.Batchelor

Cheryl.Batchelor @sunshineandtruth.bsky.social · 3h

• Other studies and case reports suggest benefits for language, social interaction, attention, and stereotyped behaviors, though effects vary among individuals.

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Cheryl.Batchelor @sunshineandtruth.bsky.social · 3h

• Other studies and case reports suggest benefits for language, social interaction, attention, and stereotyped behaviors, though effects vary among individuals.

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Reposted by Cheryl.Batchelor

Cheryl.Batchelor @sunshineandtruth.bsky.social · 3h

📚 Research Evidence

Clinical:
• A 2016 randomized controlled trial (Frye et al., Molecular Psychiatry) found that high-dose leucovorin (2 mg/kg/day up to 50 mg/day) improved verbal communication & adaptive behavior in some children w/ autism, particularly those + for folate receptor antibodies.

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Cheryl.Batchelor @sunshineandtruth.bsky.social · 3h

📚 Research Evidence

Clinical:
• A 2016 randomized controlled trial (Frye et al., Molecular Psychiatry) found that high-dose leucovorin (2 mg/kg/day up to 50 mg/day) improved verbal communication & adaptive behavior in some children w/ autism, particularly those + for folate receptor antibodies.

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Reposted by Cheryl.Batchelor

Cheryl.Batchelor @sunshineandtruth.bsky.social · 3h

• Children with FRAAs may not get enough folate into the brain, even if their blood folate levels are normal.
• Leucovorin (folinic acid) can bypass this blocked pathway & restore brain folate

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Cheryl.Batchelor @sunshineandtruth.bsky.social · 3h

• Children with FRAAs may not get enough folate into the brain, even if their blood folate levels are normal.
• Leucovorin (folinic acid) can bypass this blocked pathway & restore brain folate

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Reposted by Cheryl.Batchelor

Cheryl.Batchelor @sunshineandtruth.bsky.social · 3h

🔬 Why It’s Studied in Autism

Some individuals w/ autism show problems w/ how folate is transported into the brain, particularly due to folate receptor alpha autoantibodies (FRAAs) that block folate transport across the blood-brain barrier. This condition is called cerebral folate deficiency (CFD).

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Cheryl.Batchelor @sunshineandtruth.bsky.social · 3h

🔬 Why It’s Studied in Autism

Some individuals w/ autism show problems w/ how folate is transported into the brain, particularly due to folate receptor alpha autoantibodies (FRAAs) that block folate transport across the blood-brain barrier. This condition is called cerebral folate deficiency (CFD).

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Reposted by Cheryl.Batchelor

Cheryl.Batchelor @sunshineandtruth.bsky.social · 3h

🧠 What Leucovorin Is

form of folate (vitamin B9) that can cross into the brain more effectively than regular folic acid. It is sometimes used in medicine to:
• “Rescue” healthy cells after methotrexate chemotherapy
• Treat folate deficiency
• Address certain metabolic or mitochondrial disorders

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Cheryl.Batchelor @sunshineandtruth.bsky.social · 3h

🧠 What Leucovorin Is

form of folate (vitamin B9) that can cross into the brain more effectively than regular folic acid. It is sometimes used in medicine to:
• “Rescue” healthy cells after methotrexate chemotherapy
• Treat folate deficiency
• Address certain metabolic or mitochondrial disorders

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Reposted by Cheryl.Batchelor

Cheryl.Batchelor @sunshineandtruth.bsky.social · 3h

Leucovorin (also known as folinic acid) has been studied as a possible treatment for certain symptoms of autism spectrum disorder (ASD), particularly in children with specific metabolic or folate-related abnormalities. Here’s a summary of what is currently known:

⸻

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Cheryl.Batchelor @sunshineandtruth.bsky.social · 3h

Leucovorin (also known as folinic acid) has been studied as a possible treatment for certain symptoms of autism spectrum disorder (ASD), particularly in children with specific metabolic or folate-related abnormalities. Here’s a summary of what is currently known:

⸻

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Reposted by Cheryl.Batchelor

Cheryl.Batchelor @sunshineandtruth.bsky.social · 15h

• Sumter: 3,751
• Suwannee: 2,716
• Taylor: 1,396
• Union: 854
• Volusia: 31,157
• Wakulla: 1,830
• Walton: 3,136
• Washington: 1,249

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Cheryl.Batchelor @sunshineandtruth.bsky.social · 15h

• Sumter: 3,751
• Suwannee: 2,716
• Taylor: 1,396
• Union: 854
• Volusia: 31,157
• Wakulla: 1,830
• Walton: 3,136
• Washington: 1,249

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Reposted by Cheryl.Batchelor

Cheryl.Batchelor @sunshineandtruth.bsky.social · 15h

• Pasco: 28,271
• Pinellas: 40,408
• Polk: 42,402
• Putnam: 6,957
• St. Johns: 5,879
• St. Lucie: 17,659
• Santa Rosa: 7,133
• Sarasota: 12,653
• Seminole: 18,775

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Cheryl.Batchelor @sunshineandtruth.bsky.social · 15h

• Pasco: 28,271
• Pinellas: 40,408
• Polk: 42,402
• Putnam: 6,957
• St. Johns: 5,879
• St. Lucie: 17,659
• Santa Rosa: 7,133
• Sarasota: 12,653
• Seminole: 18,775

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Reposted by Cheryl.Batchelor

Cheryl.Batchelor @sunshineandtruth.bsky.social · 15h

• Monroe: 2,908
• Nassau: 3,061
• Okaloosa: 6,831
• Okeechobee: 2,945
• Orange: 77,647
• Osceola: 24,285
• Palm Beach: 64,176

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Cheryl.Batchelor @sunshineandtruth.bsky.social · 15h

• Monroe: 2,908
• Nassau: 3,061
• Okaloosa: 6,831
• Okeechobee: 2,945
• Orange: 77,647
• Osceola: 24,285
• Palm Beach: 64,176

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Reposted by Cheryl.Batchelor

Cheryl.Batchelor @sunshineandtruth.bsky.social · 15h

• Hillsborough: 79,031
• Holmes: 979
• Indian River: 5,876
• Jackson: 3,533
• Jefferson: 1,302
• Lafayette: 487
• Lake: 16,963
• Lee: 28,983
• Leon: 14,689
• Levy: 3,092
• Liberty: 759
• Madison: 1,258
• Manatee: 14,515
• Marion: 22,985
• Martin: 5,009

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