RNA Systems Biology Lab
@tartaglialab.bsky.social
We study RNAs and RNA-binding proteins with a strong focus on neurodegeneration. Our research combines theoretical and experimental approaches to investigate liquid–liquid phase separation and liquid–solid phase transitions of protein and RNA molecules.
Great work by Jakob! RNA co-aggregates with α-synuclein, reshaping fibril structure and inhibiting its catalytic activity. It also drives selective recruitment of transcripts—highlighting RNA as a key cofactor.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
December 2, 2025 at 7:50 AM
Great work by Jakob! RNA co-aggregates with α-synuclein, reshaping fibril structure and inhibiting its catalytic activity. It also drives selective recruitment of transcripts—highlighting RNA as a key cofactor.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Group retreat 2025 — Passo del Faiallo edition! Fantastic time with fantastic people!
November 17, 2025 at 9:11 PM
Group retreat 2025 — Passo del Faiallo edition! Fantastic time with fantastic people!
Nice interview on our new project for ALS diagnosis
𝐔𝐧𝐚 𝐧𝐮𝐨𝐯𝐚 𝐦𝐨𝐥𝐞𝐜𝐨𝐥𝐚 𝐩𝐞𝐫 𝐩𝐫𝐞𝐯𝐞𝐝𝐞𝐫𝐞 𝐥𝐚 𝐩𝐚𝐭𝐨𝐥𝐨𝐠𝐢𝐚 𝐩𝐫𝐢𝐦𝐚 𝐜𝐡𝐞 𝐬𝐢 𝐦𝐚𝐧𝐢𝐟𝐞𝐬𝐭𝐢
🔬🧬 All’Istituto Italiano di Tecnologia di Genova, il gruppo di… | Tgr Rai - Testata Giornalistica Regionale Rai
𝐔𝐧𝐚 𝐧𝐮𝐨𝐯𝐚 𝐦𝐨𝐥𝐞𝐜𝐨𝐥𝐚 𝐩𝐞𝐫 𝐩𝐫𝐞𝐯𝐞𝐝𝐞𝐫𝐞 𝐥𝐚 𝐩𝐚𝐭𝐨𝐥𝐨𝐠𝐢𝐚 𝐩𝐫𝐢𝐦𝐚 𝐜𝐡𝐞 𝐬𝐢 𝐦𝐚𝐧𝐢𝐟𝐞𝐬𝐭𝐢
🔬🧬 All’Istituto Italiano di Tecnologia di Genova, il gruppo di ricerca guidato da Gian Gaetano Tartaglia, 𝐫𝐞𝐬𝐩𝐨𝐧𝐬𝐚𝐛𝐢𝐥𝐞 𝐝𝐞𝐥𝐥’𝐑𝐍𝐀 𝐒𝐲...
www.linkedin.com
October 30, 2025 at 1:31 PM
Nice interview on our new project for ALS diagnosis
a great man and a great initiative www.youtube.com/watch?v=Nxas...
Everyone Lives: Turning Vision Into Reality | The Target ALS Origin Story | Film Premiere & Panel
YouTube video by Target ALS
www.youtube.com
October 30, 2025 at 7:50 AM
a great man and a great initiative www.youtube.com/watch?v=Nxas...
We present RIME, a deep learning model predicting RNA–RNA interactions from sequence embeddings. It outperforms thermodynamic tools and reveals low-complexity repeats as hubs in RNA networks. Adriano, Giorgio, Alessio & all - super!
www.biorxiv.org/content/10.1...
tools.tartaglialab.com/rna_rna
www.biorxiv.org/content/10.1...
tools.tartaglialab.com/rna_rna
Decoding RNA-RNA Interactions: The Role of Low-Complexity Repeats and a Deep Learning Framework for Sequence-Based Prediction
RNA-RNA interactions (RRIs) are fundamental to gene regulation and RNA processing, yet their molecular determinants remain unclear. In this work, we analyze several large-scale RRI datasets and identi...
www.biorxiv.org
October 29, 2025 at 3:32 PM
We present RIME, a deep learning model predicting RNA–RNA interactions from sequence embeddings. It outperforms thermodynamic tools and reveals low-complexity repeats as hubs in RNA networks. Adriano, Giorgio, Alessio & all - super!
www.biorxiv.org/content/10.1...
tools.tartaglialab.com/rna_rna
www.biorxiv.org/content/10.1...
tools.tartaglialab.com/rna_rna
With A. Cerase, J. Fiorentino and P. Bonfanti
I am proud to be part of CERNAIS, a team turning vision into reality — combining RNA science, AI, and therapeutic innovation to create new possibilities for rare diseases.
youtu.be/Ec4vChtk_04
cernais.com
I am proud to be part of CERNAIS, a team turning vision into reality — combining RNA science, AI, and therapeutic innovation to create new possibilities for rare diseases.
youtu.be/Ec4vChtk_04
cernais.com
Cernais_Startup_Breeze_final_event_15.10.25
YouTube video by Startup Breeze
youtu.be
October 26, 2025 at 12:05 PM
With A. Cerase, J. Fiorentino and P. Bonfanti
I am proud to be part of CERNAIS, a team turning vision into reality — combining RNA science, AI, and therapeutic innovation to create new possibilities for rare diseases.
youtu.be/Ec4vChtk_04
cernais.com
I am proud to be part of CERNAIS, a team turning vision into reality — combining RNA science, AI, and therapeutic innovation to create new possibilities for rare diseases.
youtu.be/Ec4vChtk_04
cernais.com
sweet memories from the past www.clarehall.cam.ac.uk/wp-content/u...
www.clarehall.cam.ac.uk
October 26, 2025 at 8:31 AM
sweet memories from the past www.clarehall.cam.ac.uk/wp-content/u...
My mind goes back to our previous RNA gene therapy meeting in Japan. It has been an incredible journey, and I truly appreciate the collaborations that have emerged thanks to this project.
www.rna-genetherapy.eu/advancing-me...
www.rna-genetherapy.eu/advancing-me...
Advancing Medicine through Innovation - Expo 2025 Osaka - RNA Genetherapy
www.rna-genetherapy.eu
October 7, 2025 at 2:38 PM
My mind goes back to our previous RNA gene therapy meeting in Japan. It has been an incredible journey, and I truly appreciate the collaborations that have emerged thanks to this project.
www.rna-genetherapy.eu/advancing-me...
www.rna-genetherapy.eu/advancing-me...
The third annual meeting of Spoke 3 of the National Center for Gene Therapy and RNA-based Drugs congressiconvegni.it/en/eventi/rn...
RNA-based innovative therapies for neurological disorders
The third annual meeting of Spoke 3 of the National Center
congressiconvegni.it
October 6, 2025 at 8:41 AM
The third annual meeting of Spoke 3 of the National Center for Gene Therapy and RNA-based Drugs congressiconvegni.it/en/eventi/rn...