Tanmay Bharat
@tbharat-lab.bsky.social
MRC-LMB #cryoET #biofilms #S-layers #antibiotics
https://www2.mrc-lmb.cam.ac.uk/groups/bharat/
https://www2.mrc-lmb.cam.ac.uk/groups/bharat/
Pinned
Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
www.nature.com
Assembly, architecture and functional roles of microbial surface layers
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Reposted by Tanmay Bharat
Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
November 20, 2025 at 10:16 AM
Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
Reposted by Tanmay Bharat
‘The latest surveillance data found that the number of antibiotic-resistant infections in 2024 equated to an average of nearly 400 newly reported cases a week.’
www.theguardian.com/society/2025...
www.theguardian.com/society/2025...
Deaths linked to antibiotic-resistant superbugs rose 17% in England in 2024
Data also shows an average of nearly 400 newly reported cases of antibiotic-resistant infections a week last year
www.theguardian.com
November 13, 2025 at 11:27 PM
‘The latest surveillance data found that the number of antibiotic-resistant infections in 2024 equated to an average of nearly 400 newly reported cases a week.’
www.theguardian.com/society/2025...
www.theguardian.com/society/2025...
Reposted by Tanmay Bharat
Pleased to share our review on S-layers with @bupbuse.bsky.social, Andriko von Kügelgen, and @tbharat-lab.bsky.social, where we explore recent advances and argue that deeper insight into S-layers is key to deciphering microbial interactions and community organization. @mpi-bio-fml.bsky.social
Assembly, architecture and functional roles of microbial surface layers
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
www.nature.com
November 13, 2025 at 9:16 PM
Pleased to share our review on S-layers with @bupbuse.bsky.social, Andriko von Kügelgen, and @tbharat-lab.bsky.social, where we explore recent advances and argue that deeper insight into S-layers is key to deciphering microbial interactions and community organization. @mpi-bio-fml.bsky.social
Also see the associated primer video on S-layers made by the @mrclmb.bsky.social Visual Aids department Konstantinos Alexandrou and Shraddha Nayak!
www.youtube.com/watch?v=fgSf...
www.youtube.com/watch?v=fgSf...
Introduction to microbial surface layers (S-layers)
YouTube video by MRC Laboratory of Molecular Biology
www.youtube.com
November 13, 2025 at 8:14 PM
Also see the associated primer video on S-layers made by the @mrclmb.bsky.social Visual Aids department Konstantinos Alexandrou and Shraddha Nayak!
www.youtube.com/watch?v=fgSf...
www.youtube.com/watch?v=fgSf...
Assembly, architecture and functional roles of microbial surface layers
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
www.nature.com
November 13, 2025 at 8:14 PM
Assembly, architecture and functional roles of microbial surface layers
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Grows quite slowly over months, maybe that’s why? Lots to study and much to learn…
November 10, 2025 at 2:57 PM
Grows quite slowly over months, maybe that’s why? Lots to study and much to learn…
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Be our neighbour, please apply!
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.
mrc.tal.net/vx/appcentre...
mrc.tal.net/vx/appcentre...
Quick Check Needed
mrc.tal.net
October 29, 2025 at 6:29 PM
Be our neighbour, please apply!
Reposted by Tanmay Bharat
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
October 15, 2025 at 6:33 AM
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
It's deep when the GPU starts making a loud noise
September 16, 2025 at 5:51 PM
It's deep when the GPU starts making a loud noise
Reposted by Tanmay Bharat
The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41...
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
September 16, 2025 at 7:43 AM
The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41...
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
Reposted by Tanmay Bharat
Excited about our most recent collaboration with the Wong lab, lead by William Schmidt, describing a T4P and CdrA-mediated mechanism of sensing surface EPS. Fun stuff and great work William and team.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 5, 2025 at 12:21 PM
Excited about our most recent collaboration with the Wong lab, lead by William Schmidt, describing a T4P and CdrA-mediated mechanism of sensing surface EPS. Fun stuff and great work William and team.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
August 31, 2025 at 6:44 PM
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
Reposted by Tanmay Bharat
My wonderful colleage Colin Kleanthous is raising money for the MND association. Please support Colin in this worthy endeavor! www.justgiving.com/page/colin-k...
(Please repost!)
(Please repost!)
Colin Kleanthous' fundraiser for Motor Neurone Disease Association
Help Colin Kleanthous raise money to support Motor Neurone Disease Association
www.justgiving.com
July 15, 2025 at 7:21 AM
My wonderful colleage Colin Kleanthous is raising money for the MND association. Please support Colin in this worthy endeavor! www.justgiving.com/page/colin-k...
(Please repost!)
(Please repost!)
Reposted by Tanmay Bharat
Sofia Lövestam's vault structure is now online in Structure @cellpress.bsky.social. 🥳
How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look.
www.cell.com/structure/fu...
How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look.
www.cell.com/structure/fu...
Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps
Lövestam and Scheres present a cryo-EM structure of vault particles, found during
tau filament extraction from progressive supranuclear palsy (PSP) brain tissue. They
reveal a symmetry shift at the va...
www.cell.com
August 12, 2025 at 4:05 PM
Sofia Lövestam's vault structure is now online in Structure @cellpress.bsky.social. 🥳
How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look.
www.cell.com/structure/fu...
How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look.
www.cell.com/structure/fu...
Reposted by Tanmay Bharat
#ICYMI, @newscientist.com spoke to Wes Robertson, Group Leader in the LMB’s PNAC Division, about the ‘gargantuan effort’ behind synthesising E. coli with just 57 codons:
www.newscientist.com/article/2490...
#LMBintheNews
www.newscientist.com/article/2490...
#LMBintheNews
E. coli genome has been remade with 101,000 changes to its DNA
The recoded bacterium uses only 57 of the 64 possible genetic codes, freeing up seven to be used for different purposes
www.newscientist.com
August 8, 2025 at 2:37 PM
#ICYMI, @newscientist.com spoke to Wes Robertson, Group Leader in the LMB’s PNAC Division, about the ‘gargantuan effort’ behind synthesising E. coli with just 57 codons:
www.newscientist.com/article/2490...
#LMBintheNews
www.newscientist.com/article/2490...
#LMBintheNews
Reposted by Tanmay Bharat
The story of the discovery of monoclonal antibodies 50 years ago shows how the free exchange of ideas can lead to life-changing treatments
go.nature.com/45GeSM0
go.nature.com/45GeSM0
Monoclonal antibodies revolutionized biomedical science and health care
The story of the discovery of these molecules 50 years ago shows how the free exchange of ideas can lead to life-changing treatments.
go.nature.com
August 7, 2025 at 3:55 PM
The story of the discovery of monoclonal antibodies 50 years ago shows how the free exchange of ideas can lead to life-changing treatments
go.nature.com/45GeSM0
go.nature.com/45GeSM0
Reposted by Tanmay Bharat
Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 5, 2025 at 10:43 AM
Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Tanmay Bharat
The LMB recently hosted a symposium to mark 50 years since Richard Henderson and Nigel Unwin published the structure of bacteriorhodopsin, the first 3D structure of a protein determined by #cryoEM.
Read about the event and find more photos here: www2.mrc-lmb.cam.ac.uk/the-structur...
#LMBNews 🧪🔬
Read about the event and find more photos here: www2.mrc-lmb.cam.ac.uk/the-structur...
#LMBNews 🧪🔬
August 4, 2025 at 2:33 PM
The LMB recently hosted a symposium to mark 50 years since Richard Henderson and Nigel Unwin published the structure of bacteriorhodopsin, the first 3D structure of a protein determined by #cryoEM.
Read about the event and find more photos here: www2.mrc-lmb.cam.ac.uk/the-structur...
#LMBNews 🧪🔬
Read about the event and find more photos here: www2.mrc-lmb.cam.ac.uk/the-structur...
#LMBNews 🧪🔬
Highly recommend, speaking from experience!
This is a genuinely huge opportunity for the right person.
We @dunnschool.bsky.social are proud not only of our discovery science to transform human health, but also of the support we offer early career fellows.
Join us, and launch your independent career!
Please share.
We @dunnschool.bsky.social are proud not only of our discovery science to transform human health, but also of the support we offer early career fellows.
Join us, and launch your independent career!
Please share.
📣 Applications now open 📣
We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease!
Please share!
www.path.ox.ac.uk/work-with-us...
We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease!
Please share!
www.path.ox.ac.uk/work-with-us...
July 30, 2025 at 6:55 PM
Highly recommend, speaking from experience!