1/ In April 2024, a routine lab isolate of Salmonella Typhi showed phenotypic resistance to ceftriaxone, a key antibiotic for treating typhoid. By September, 47 similar cases had been identified across Bangladesh, and resistance had risen to 5%.

I'm super happy to share this preprint on ‘Distribution of capsule and O types in #Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: meta-analysis of genome-predicted serotype prevalence and potential vaccine coverage’
doi.org/10.1101/2025...

One ceftriaxone-resistant #typhoid case last year set us on a path that is now live on Emerging Infectious Diseases.
47 cases in months, resistance rose from 0 to 5%. We spoke with patients, sequenced samples. 4.3.1.2.B1 lineage+blaCTX-M-15 on pCROB1. #AMR #PublicHealth
wwwnc.cdc.gov/eid/article/...

1/ Outbreaks don't stop during holidays. #Surveillance is year-round work and here is an urgent report on an ongoing outbreak of ceftriaxone-resistant #Salmonella #Typhi in Bangladesh.
📄 Findings: www.medrxiv.org/content/10.1... 🧵

This is amazing and important work by Glen Carter and colleagues at the University of Melbourne

'Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin in Enterococcus'

www.nature.com/articles/s41...

When people ask me what we need the most for typhoid treatment, I always say a rapid diagnostic to accurately detect typhoid/paratyphoid. This truly could be a game changer if we can adopt it in clinical practice in LMICs. Great work from colleagues at @chrfbd.bsky.social and collaborators!!

Had the amazing opportunity to present our work at HCA Asia. RSV infections are a major health burden amongst children in Bangladesh and we aim to learn about the pathophysiology of RSV infections using single cell sequencing. Stay tuned for more insights from our work!

My heart swells with pride every time I realise that Bangladesh is generating its own single cell data @chrfbd.bsky.social !! Excellent presentation by @yogihooda.bsky.social at the #HCAAsia2024 meeting describing the changes in the nasal mucosa during #RSV infections!

Huping Wang and Manu Hegde, in @cellbiol-mrclmb.bsky.social have found a factor that accelerates protein deliveries to the endoplasmic reticulum

Click here to read more about it: www2.mrc-lmb.cam.ac.uk/discovery-of...

#LMBResearch

Aging together, striving to become better scientists together, getting through this world together.
14 years with @yogihooda.bsky.social since our first date night - crazy!!!

Dr. Senjuti Saha recently took the stage at Cambridge University to share insights on the growing crisis of neonatal infections and antimicrobial resistance (AMR) in Bangladesh. She discussed how CHRF’s invasive bacterial disease surveillance is revealing crucial data on Klebsiella pneumoniae. (1/4)

Excited to share our preprint on characterizing NACHO, a ER-resident membrane protein that plays an essential role in assembling pentameric ion channels, like GABA and nicotinic acetylcholine receptors in our brains. #IonChannels #Neuroscience (1/5) www.biorxiv.org/content/10.1...

Recently, I got an opportunity to present 18 years of impactful research from CHRF in Bangladesh at the 2024 Klebsiella Epidemiology and Biology Symposium in Paris—the first-ever event dedicated to this infection. (1/3)