Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up!
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

On our three year lab anniversary (give or take a few days!), I'm proud to share the first original work produced within the Meers Lab: Plate-CUT&Tag! Take a look: www.biorxiv.org/content/10.1... 1/3

In yeast spores, polarity emerges from a different playbook.

Dr. Michael McMurray (University of Colorado Anschutz) reveals how Bud8, Bud5, and Cdc42 machinery help spores establish polarity without relying on classic cortical landmarks.

www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology

Our paper is out in its final form! Back in April 2023, my coauthor Aleks Radakovic, then a PhD student, approached me after a talk in Chicago to ask what I thought an aminoacylated tRNA would look like if we pulled it through a @nanopore.
doi.org/10.1038/s414...

Why do #StemCells have lower levels of facultative #heterochromatin, defined by H3K27me3, compared to differentiated cells? By artificially lengthening G1 phase, @4everbiochemist.bsky.social &co show that G1 length is an essential determinant of H3K27me3 landscape @plosbiology.org 🧪 plos.io/4lKfztO

In #G3journal, @4everbiochemist.bsky.social and colleagues assessed the role of essential histone chaperone Spn1 in maintaining #yeast chromatin structure. They found that Spn1 preserves nucleosomal, subnucleosomal, and non-nucleosomal protections across the genome.

Read more: buff.ly/kRe9RH3

Really excited to have contributed (in minor part) to this study from the
@SarthyLab
on chromatin vulnerabilities in CBFA2T3-GLIS2 AMLs. A clever synthesis of chromatin profiling, single-cell RNA, and DepMap data to uncover both mechanism and target 1/6 www.biorxiv.org/content/10.1...

Please read our preprint: "G1 length dictates heterochromatin landscape"
www.biorxiv.org/content/10.1...