🧠 These findings highlight how inclusive educational approaches can advance health literacy early in life and support equitable, scalable digital health strategies for diverse learning needs.

Read more here: doi.org/10.1017/neu....

💡 The hybrid format (digital + classroom) and easy-to-read, gamified materials made the program accessible, engaging, and equally effective across rural and urban schools, as well as regular and special education centers.

#HealthLiteracy #DigitalHealth #Neurodiversity #EquityInHealth

🧩 Clinical relevance:
Psilocybin shows promise as a novel, mechanism-distinct intervention for depression.

🔗 Read the full review: doi.org/10.1017/neu....

#Psilocybin #Depression #PsychedelicMedicine

🌿 Results:
Psilocybin produced rapid antidepressant effects, often after one or two supported sessions.
Improvements were sustained for several weeks or months.
Treatment is generally well-tolerated with some mild headaches and transient anxiety - typically manageable in controlled settings.

🎯 This ratio may be explored in precision therapeutics aimed at modulating TRYCAT metabolism to reduce neuroinflammation and cognitive impairment.

Read + here: doi.org/10.1017/neu....

#Psychiatry #Psychopharmacology #Neuroscience #TRYCAT #Schizophrenia #Inflammation #PrecisionMedicine

⚡Proinflammatory cytokines activate breakdown into tryptophan catabolites (TRYCATs). However, some TRYCATs (like kynurenine, 3HK) are neurotoxic!

Patients with MNP exhibit 🔺 quinolinic acid and 🔻 kynurenic acid,

shifting the quinolinic:kynurenic ratio toward neurotoxicity.

🔗 Read the full paper: doi.org/10.1017/neu....
#Antipsychotic #Cobenfy #Xanomeline #CME

It is a potent mid-tier option,
Shared decision-making, weighing symptom severity, side effects:
✅ D2-based intolerants
✅ Individuals w/ metabolic concerns
✅ Prominent cognitive & negative symptoms
✅ Partial responders
➡️ GI side effects can be a barrier
➡️ Don't switch stable patients

This work suggests that vocal analysis could become a practical, non-invasive tool for assessing acute stress in clinical and research settings.

Read the paper here: doi.org/10.1017/neu....
#Psychology #PsychiatryResearch #digitalpsychiatry

Voice revealed:
🎵 Specific changes in speech rhythm, pitch, and energy correlated with rises in both cortisol and state anger
🚻 These vocal patterns differed meaningfully between males and females
🤖 Computational models demonstrated that speech can predict stress-related scores w/ moderate accuracy

Check the paper to understand how this meta-analysis explored global disparities and charts a path to build competence across the entire healthcare team🌍
doi.org/10.1017/neu....

#Clozapine #Schizophrenia #MentalHealthPolicy #InterprofessionalEducation #Psychiatry #Pharmacy #Nursing

Policy makers & clinical leaders: 💡 How are we investing in comprehensive, inter-professional training for clozapine management in our systems?

These findings provide a deeper mechanistic understanding of its clinical effects and reveal potential treatment targets for schizophrenia.

🔗Find more on: doi.org/10.1017/neu....
#MolecularBiology #antipsychotic

🧬 Transcription (AP-1 Complex)
🧱 Cellular Structure (Cytoskeleton)
📦 Intracellular trafficking of receptors & Endocytosis
🧪 Epigenetics (Histone Binding)

📋🔍Still, more research is needed:
We need adequately large, randomized, well-controlled studies to confirm whether GLP-1 RAs deliver clinically meaningful improvements and risk reduction in OUD.

Check the paper at: doi.org/10.1017/neu....

#Addiction #GLP1 #HarmReduction #Opioids #Fentanyl

🐁Complementary preclinical work shows converging effects: these agents reduce heroin-seeking behavior and opioid self-administration in animal models.

🍽️🧠How could these findings support integrated use?
GLP-1 signaling intersects with reward pathways, satiety, and stress responses.