Nature Metabolism, Published online: 13 May 2025; doi:10.1038/s42255-025-01296-9In this Review, the authors present a roadmap towards achieving consensus on development, analysis and interpretation of single-cell transcriptomics data in adipose tissue, including discussion of roadblocks, best practices and ideal cell-type markers for annotation of adipose tissue cell types in mice and humans.

By centralizing previously dispersed datasets, we developed Adipose Tissue Knowledge Portal to integrate clinical and experimental results with transcriptomic and proteomic data from >6,000 women and men. The platform includes multiple adipose depots,…

Body weight and body mass index alone are not enough to predict whether someone will develop a metabolic disease. A new atlas of cells in fat tissue could help to explain why some overweight people st...