Agnese Cristini
@agnesecristini.bsky.social
190 followers
320 following
2 posts
Inserm Research scientist at CRCT | Interested in R-loops, Transcription, Chromatin, Genome Instability, Cancer | Views are my own
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Pierre Caron
@pierrecaron.bsky.social
· Apr 3
SRSF2 overexpression induces transcription-/replication-dependent DNA double-strand breaks and interferes with DNA repair pathways to promote lung tumor progression
Abstract. SRSF2 (serine/arginine-rich splicing factor 2) is a critical regulator of pre-messenger RNA splicing, which also plays noncanonical functions in
academic.oup.com
Reposted by Agnese Cristini
Palancade lab
@palancadelab.bsky.social
· Mar 11
Reposted by Agnese Cristini
Reposted by Agnese Cristini
Mark Dawson
@mafdawson.bsky.social
· Jan 2
mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription
Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.
www.cell.com
Reposted by Agnese Cristini
