7/7 Friends 🎈 I am incredibly grateful to have worked alongside my wonderful co-first author, @oriolmb.bsky.social. This project has been a surprising journey, filled with challenges, triumphs, and lots of laughs. Cheers to the friendships made through science!

6/7: Thanks! This work wouldn't have been possible without the contributions of co-authors: @oriolmb.bsky.social Andrea Gomez and all the authors: Alex Calon, Anna Labernadie @challopeau.bsky.social et al. Special thanks to @xaviertrepat.bsky.social for the opportunity to take part in this project.

5/7: Impact. MIRO offers a valuable ex vivo platform that helps uncover mechanisms of immune exclusion potentially accelerating drug development, bridging the gap from lab to clinic 💊, ultimately improving patient outcomes. #TranslationalResearch

4/7: MIRO enables high throughput testing of #immunotherapies, opening new possibilities for personalized cancer treatments.
As a proof of concept, we restored anti-cancer immunity in resistant/immune-excluded HER2+ breast cancer with IL2 treatment. 💪
🎥 Immune cell migration upon treatment

3/7: Why MIRO is unique?
✅ Immunocompetent: tracks #ImmuneCells movement & interactions
✅ Cells self-organize & build their own extra-cellular matrix
✅ Cost-effective, reproducible & user-friendly
🎥 cellular organization in MIRO
#ECM #TumorEcosystem

2/7: MIRO is an open fluidic device that models the tumour-stroma interface using patient-derived cells. This allows us to recreate aspects of the #TumorMicroenvironment and study immune cell interactions in the lab. 🔎🧫 #Microfluidics #OnChip

1/7: New paper alert! Excited to share our co-first author paper on Micro Immune Response On-chip (MIRO) a model that recreates the tumour-stroma interface for immunotherapy testing! @oriolmb.bsky.social and I wrote this thread to break it down for you. 👇🧵
Read more: www.nature.com/articles/s41...

Work conceived by Anna Labernadie during her postdoc in the lab—now running her group at CIPF—in collaboration with Alex Calon from @researchmar.bsky.social. Congrats to first authors @aliperri.bsky.social , Andrea Gómez and @oriolmb.bsky.social ! ibecbarcelona.eu/researchers-...

New paper from the lab🎈. Introducing Micro Immune Response On-chip (MIRO), a device that replicates tumors and their microenvironment to better understand responses to immunotherapies (cyan=immune cells, red=cancer, green=CAFs).
www.nature.com/articles/s41...
@ibecbarcelona.eu

Kicking off my Bluesky account with great news! Our work on MIRO, a device designed to study how cells respond to different immunotherapies, is now published. Have a look!