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Analytical Methods
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The home of discoveries in the applied analytical and bioanalytical sciences, for the benefit of society and humanity.

Published by @rsc.org 🌐 Website: rsc.li/analyticalmethods

Reposted by Analytical Methods
(RSC A Meth) Development of a new procedure for selecting internal standards for gas chromatography/mass spectrometry-based plasma metabolome analysis: Anal. Methods, 2025, Advance Article
DOI: 10.1039/D5AY01659B, Technical NoteShin Nishiumi, Tomonori Yokoyama, Noriyuki Ojima
Mass… #MassSpecRSS
Development of a new procedure for selecting internal standards for gas chromatography/mass spectrometry-based plasma metabolome analysis
Anal. Methods, 2025, Advance Article DOI: 10.1039/D5AY01659B, Technical NoteShin Nishiumi, Tomonori Yokoyama, Noriyuki Ojima Mass spectrometry, including GC/MS, LC/MS, and CE/MS, can analyze many different molecules in a single measurement, facilitating metabolome analysis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
dlvr.it
November 25, 2025 at 1:02 AM
Reposted by Analytical Methods
End-to-End Workflows for Liquid Biopsy Biotyping Analysis Using Combined MALDI MS and Machine Learning Approach #AnalMethods pubs.rsc.org/en/content/a...
End-to-End Workflows for Liquid Biopsy Biotyping Analysis Using Combined MALDI MS and Machine Learning Approach
MALDI MS analysis of liquid biopsy combined with ML enables non-invasive disease screening and monitoring. Here we present an open-source R-based workflow covering all steps from raw data preprocessin...
pubs.rsc.org
November 25, 2025 at 7:36 PM
Reposted by Analytical Methods
Stability-indicating study of Iguratimod: Isolation and characterization of potential degradant using Preparative HPLC-MS, LC-HRMS, and NMR techniques #AnalMethods pubs.rsc.org/en/content/a...
Stability-indicating study of Iguratimod: Isolation and characterization of potential degradant using Preparative HPLC-MS, LC-HRMS, and NMR techniques
Iguratimod (IGRD), a disease-modifying antirheumatic drug, emerged as a promising therapeutic agent due to its potent immunomodulatory effect in autoimmune diseases. In this study, a green and selecti...
pubs.rsc.org
November 21, 2025 at 2:56 PM
On the front cover of issue 45 of Analytical Methods:
Transmission powder X-ray diffraction technique for precise identification and quantification of drug polymorphs – a case study using metformin embonate.
Jagadeesh Babu Nanubolu et al.
pubs.rsc.org/en/content/a...
November 24, 2025 at 8:58 AM
Reposted by Analytical Methods
Optimized extraction and analytical protocols for guanitoxin: an organophosphate cyanobacterial neurotoxin of environmental concern pubs.rsc.org/en/content/a...
Optimized extraction and analytical protocols for guanitoxin: an organophosphate cyanobacterial neurotoxin of environmental concern
This study evaluated cell growth, chlorophyll-a production, and guanitoxin (GNT) synthesis by the cyanobacterium Sphaerospermopsis torques-reginae (strain ITEP-24) in different culture media over 52 d...
pubs.rsc.org
November 19, 2025 at 8:55 AM
On the cover of issue 44:
Demonstrating the application of a liquid chromatography-mass spectrometry method for the determination of phthalate diesters in complex solid and liquid environmental samples.
#OpenAccess from Fiona Regan et al @dublincityuni.bsky.social.
pubs.rsc.org/en/content/a...
November 17, 2025 at 9:13 AM
Reposted by Analytical Methods
(RSC A Meth) MALDI mass spectrometry analysis of N-glycans through DMTMM-mediated benzylamidation and Girard's reagent P labeling: Anal. Methods, 2025, Advance Article
DOI: 10.1039/D5AY01494H, Technical NoteMinju Kim, Eun Ju Lee, Sohee Yoon, Hae-Min Park
MALDI-MS-based N-glycan… #MassSpecRSS
MALDI mass spectrometry analysis of N-glycans through DMTMM-mediated benzylamidation and Girard's reagent P labeling
Anal. Methods, 2025, Advance Article DOI: 10.1039/D5AY01494H, Technical NoteMinju Kim, Eun Ju Lee, Sohee Yoon, Hae-Min Park MALDI-MS-based N-glycan analysis with both DMTMM-mediated benzylamidation and GP labeling allows the sensitive measurement of intact N-glycans released from glycoproteins. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
dlvr.it
November 15, 2025 at 1:01 AM
On the front cover of issue 43 of Analytical Methods:
A liquid crystal-based sensor for real-time, selective, and visual detection of vanillin over coumarin in food samples.
Sachin Kumar Singh et al.
pubs.rsc.org/en/content/a...
November 10, 2025 at 8:46 AM
Available to read now via #OpenAccess:
pubs.rsc.org/en/Content/A...
Detection of anticoagulant rodenticides by direct analysis in real time time-of-flight mass spectrometry: novel screening techniques and rapid semi-quantitative determination
Dayue Shang et al
@lifeatbcit.bsky.social @sfu.ca
November 5, 2025 at 10:21 AM
On the front cover of issue 42 of Analytical Methods:
Simple preparation of an Au nanoparticle dispersed substrate by arc plasma deposition and its application in bio-sensing using LSPR.
Takeshi Ito et al.
pubs.rsc.org/en/content/a...
November 3, 2025 at 9:12 AM
📢 Welcome our newest Analytical Methods Advisory Board members: Dr. Stefano Cinti from the University of Naples, IT and Dr. Bob Pirok from the University of Amsterdam, NL.

Please join us in welcoming Stefano and Bob to the Analytical Methods AB!🙌

#analyticalchemistry #biosensors #chromatography
October 28, 2025 at 10:04 AM
On the front cover of issue 41 of Analytical Methods:
Nanoscale mapping of nucleolin–aptamer interactions on lung cancer cells reveals binding affinity hierarchy and spatial heterogeneity.
Weidong Zhao, Feng Jiang et al.
pubs.rsc.org/en/content/a...
October 27, 2025 at 9:37 AM
Reposted by Analytical Methods
Desorption electrospray ionization mass spectrometry: advances in instrumentation, high-throughput analysis, and imaging applications pubs.rsc.org/en/cont...

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#proteomics #prot-paper
October 23, 2025 at 2:01 PM
Reposted by Analytical Methods
(RSC A Meth) Desorption electrospray ionization mass spectrometry: advances in instrumentation, high-throughput analysis, and imaging applications: Anal. Methods, 2025, Advance Article
DOI: 10.1039/D5AY01323B, Tutorial ReviewKhaled W. Omari
DESI-MS is an ambient ionization, rapid, and… #MassSpecRSS
Desorption electrospray ionization mass spectrometry: advances in instrumentation, high-throughput analysis, and imaging applications
Anal. Methods, 2025, Advance Article DOI: 10.1039/D5AY01323B, Tutorial ReviewKhaled W. Omari DESI-MS is an ambient ionization, rapid, and high-throughput molecular analysis directly from surfaces. Recent advancements enhance its performance in imaging and diagnostics. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
dlvr.it
October 22, 2025 at 2:07 AM
On the front cover of issue 40 of Analytical Methods:
Considerations for deconvolution of oligonucleotide mass spectra in quality control.
Michael Rühl.
pubs.rsc.org/en/content/a...
October 20, 2025 at 8:16 AM
Available to read now via #OpenAccess
pubs.rsc.org/en/Content/A...
Demonstrating the application of a liquid chromatography-mass spectrometry method for the determination of phthalate diesters in complex solid and liquid environmental samples
Fiona Regan et al
@dublincityuni.bsky.social
October 17, 2025 at 7:33 AM
On the front cover of issue 39 of Analytical Methods:
A protein-nanoparticle conjugate platform for simplified and sensitive protease activity assays.
Masafumi Sakono et al.
pubs.rsc.org/en/content/a...
October 13, 2025 at 9:14 AM
Reposted by Analytical Methods
In honour of the 2025 #NobelPrize in Chemistry, we’ve curated a collection of impactful articles from across RSC journals on metal–organic frameworks (MOFs) 🏆

Free to read until the end of November 👉 pubs.rsc.org/en/journals/...
October 8, 2025 at 1:12 PM
On the front cover of issue 38 of Analytical Methods:
Comonomer distribution analysis of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)s using high-resolution MALDI-TOF mass spectrometry.
Naoki Kanayama et al.
pubs.rsc.org/en/content/a...
October 6, 2025 at 7:46 AM
Reposted by Analytical Methods
(RSC A Meth) Comonomer distribution analysis of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)s using high-resolution MALDI-TOF mass spectrometry: Anal. Methods, 2025, 17,7618-7627
DOI: 10.1039/D5AY00910C, PaperNaoki Kanayama, Sayaka Nakamura, Shin Sano, Mami Tanaka, Noriko Takahara,… #MassSpecRSS
Comonomer distribution analysis of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)s using high-resolution MALDI-TOF mass spectrometry
Anal. Methods, 2025, 17,7618-7627 DOI: 10.1039/D5AY00910C, PaperNaoki Kanayama, Sayaka Nakamura, Shin Sano, Mami Tanaka, Noriko Takahara, Hiroaki Sato, Hideaki Hagihara The comonomer distribution of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) was depicted as a number distribution plot of 3-hydroxynexanoate via high-resolution mass spectral data analysis. The content of this RSS Feed (c) The Royal Society of Chemistry
dlvr.it
October 3, 2025 at 3:03 AM
Reposted by Analytical Methods
Scientists developed a DNA switch that turns a single viral gene fragment into about 1250 signals, enabling ultra sensitive detection of SARS-CoV-2 down to 0.04 fM and adaptable for other viruses like rabies.

pubs.rsc.org/en/content/a...
An isothermal amplification-bridged ratiometric DNA switch for sensitive detection of viral gene fragments
The detection of viral gene fragments is essential for diagnosing and screening viral infections, managing virus transmission, and controlling epidemics. In this study, we developed an isothermal ampl...
pubs.rsc.org
August 26, 2025 at 6:33 PM
Reposted by Analytical Methods
#NMRchat Optimizing the extraction of ursolic acid from loquat leaf using 1H-qNMR http://pubs.rsc.org/en/Content/ArticleLanding/2025/AY/D5AY01340B
September 30, 2025 at 12:11 PM
In our latest issue:
A pyrolysis gas chromatography high resolution mass spectrometry (Py-GC-MS) method for analysis of phthalic acid esters and its application for screening e-waste materials
Ivan Kourtchev et al
@coventrycawr.bsky.social @deakinuniversity.bsky.social
pubs.rsc.org/en/content/a...
A pyrolysis gas chromatography high resolution mass spectrometry (Py-GC-MS) method for analysis of phthalic acid esters and its application for screening e-waste materials
The increasing volume of electronic waste (e-waste) is a significant global environmental and public health concern. Phthalic acid esters (PAEs) are used as plasticisers in insulation coatings of elec...
pubs.rsc.org
September 30, 2025 at 8:32 AM