Anh Hoang Le, PhD 🏳️🌈
@anhhle2702.bsky.social
Sir Henry Wellcome fellow studying macrophage migration and mechanobiology @UCL. BSc Biochemistry @Bristol. PhD Cancer Biology @CRUK Scotland Institute. 🏴
Cell lover by day, takeaway lover by night.
https://hoanganhle2602.wixsite.com/cellsandtheirwonders
Cell lover by day, takeaway lover by night.
https://hoanganhle2602.wixsite.com/cellsandtheirwonders
I found these immune cells just finished mitosis but their midbody is still yet to be resolved. How cool? If you zoom in to the midbody, you can see its classical shape just like in the textbooks. I love these little details.
October 14, 2025 at 10:56 AM
I found these immune cells just finished mitosis but their midbody is still yet to be resolved. How cool? If you zoom in to the midbody, you can see its classical shape just like in the textbooks. I love these little details.
YO, what's up with all these almost-witchcraft techniques?? In this paper, they develop a way to freeze cells so quickly that it preserves Calcium waves midway!! WHAT??? HELLO??? So now you can do 3D reconstruction of calcium waves with just a normal confocal. www.nature.com/articles/s41...
August 26, 2025 at 9:11 PM
YO, what's up with all these almost-witchcraft techniques?? In this paper, they develop a way to freeze cells so quickly that it preserves Calcium waves midway!! WHAT??? HELLO??? So now you can do 3D reconstruction of calcium waves with just a normal confocal. www.nature.com/articles/s41...
I was looking through my old microscopy videos, and found this perfect shot of a macropinosome forming through the collapse of an actin-driven membrane ruffle (cyan). Immediately, CRYI-A (orange) is recruited to the vesicle to finish the job. Still in awe with this process after all those years!
July 31, 2025 at 11:19 PM
I was looking through my old microscopy videos, and found this perfect shot of a macropinosome forming through the collapse of an actin-driven membrane ruffle (cyan). Immediately, CRYI-A (orange) is recruited to the vesicle to finish the job. Still in awe with this process after all those years!
It's one of those experiments where you don't really know if it's worth doing it but you're also curious to know what happens if you do it.
I adapted another Optogenetic tool in 🐸 that allows one to change the migration direction of immune cells. It works beautifully, but is it useful for me, Idk 😅
I adapted another Optogenetic tool in 🐸 that allows one to change the migration direction of immune cells. It works beautifully, but is it useful for me, Idk 😅
July 19, 2025 at 6:44 PM
It's one of those experiments where you don't really know if it's worth doing it but you're also curious to know what happens if you do it.
I adapted another Optogenetic tool in 🐸 that allows one to change the migration direction of immune cells. It works beautifully, but is it useful for me, Idk 😅
I adapted another Optogenetic tool in 🐸 that allows one to change the migration direction of immune cells. It works beautifully, but is it useful for me, Idk 😅
1/I'm excited to share my review with CSHL exploring the concept of neighbouring cells as substrate to guide the collective migration of other cells. We tend to focus on cell-matrix interactions, but forget that within tissue, cell-cell interactions exist.
cshperspectives.cshlp.org/content/earl...
cshperspectives.cshlp.org/content/earl...
May 20, 2025 at 11:55 AM
1/I'm excited to share my review with CSHL exploring the concept of neighbouring cells as substrate to guide the collective migration of other cells. We tend to focus on cell-matrix interactions, but forget that within tissue, cell-cell interactions exist.
cshperspectives.cshlp.org/content/earl...
cshperspectives.cshlp.org/content/earl...
I think I finally got the right dose for the Optogenetic tool. Embryos are happy. Cells are happy. Localisation looks good. Science takes so much time, but when it works, it always makes me want to do more (until it doesn't and then I want to die). #FluorescenceFriday
March 21, 2025 at 9:02 PM
I think I finally got the right dose for the Optogenetic tool. Embryos are happy. Cells are happy. Localisation looks good. Science takes so much time, but when it works, it always makes me want to do more (until it doesn't and then I want to die). #FluorescenceFriday
So happy I finally made the ILID-SspB Optogenetic system work in 🐸. Though not perfect and need some optimisations, it worked. Got the constructs from @joachimgoedhart.bsky.social and made it into a frog expression system. Here is the Opto-PH-Rho in action. It's real, guys!! #FluorescenceFriday
March 14, 2025 at 3:49 PM
So happy I finally made the ILID-SspB Optogenetic system work in 🐸. Though not perfect and need some optimisations, it worked. Got the constructs from @joachimgoedhart.bsky.social and made it into a frog expression system. Here is the Opto-PH-Rho in action. It's real, guys!! #FluorescenceFriday
The vector field of this spreading tissue looks just like the sun during a coronal mass ejection event #MicroscopyMonday
December 2, 2024 at 6:28 PM
The vector field of this spreading tissue looks just like the sun during a coronal mass ejection event #MicroscopyMonday