Bryan Vandenbrink
arctichominid.bsky.social
Bryan Vandenbrink
@arctichominid.bsky.social
All views to be attributed first to Diogenes, than my own. I reserve the right to ridicule the ridiculous.

All errors intended. OCD is mental illness.
Not to mention the fact that simply developing a next generation anti-ballistic missile defence network defeats the point of M.A.D.

China/Russia/literally everyone with nukes will see this as a massive provocation.
May 23, 2025 at 6:14 PM
Obligatory Monty Python reference:
"Just remember that you're standing on a planet that's evolving

And revolving at nine hundred miles an hour

That's orbiting at nineteen miles a second, so it's reckoned,

A sun that is the source of all our power"

www.youtube.com/watch?v=buqt...
Galaxy Song - Monty Python's The Meaning of Life
YouTube video by Monty Python
www.youtube.com
May 14, 2025 at 4:01 PM
Fair, enter 3D printing stage left!

The prices for stepper motors, motor drivers, etc have all been driven progressively further down in the last 10 years.

www.youtube.com/watch?v=MNTu...
Finding the Best NEMA17 Stepper Motor: LDO Motors, STEPPERONLINE and more tested with a dynamometer
YouTube video by Engineer Bo
www.youtube.com
May 14, 2025 at 2:10 PM
Basically, a 3D microtome scanning mill feeding into a retrofitted MiSeq for mass processing insect slices.

www.youtube.com/watch?v=iKQ3...
Creality CR-30 3DPrintMill belt 3D printer: What to know before you buy
YouTube video by Teaching Tech
www.youtube.com
May 7, 2025 at 6:37 PM
A belt drive system with the guts of a MiSeq and a pre-arranged grid of thousands of microtome slices could in theory used to generate lipid tissue photography that can be stitched back together into a 3d model of insects and include where and what their tissue is made of.

Provided it'll glow.
May 7, 2025 at 6:30 PM
Follow-up, I don't have the MiSeq in my possession yet but I may look into exactly this.

Recreating 3D images from insects and histological samples and fluorescing tissue microtome slices could be very cool.

A key question I have relates to cold tolerance in Arctic insects and sub-Arctic insects.
May 7, 2025 at 6:26 PM
Cool!
May 7, 2025 at 6:01 PM
Reposted by Bryan Vandenbrink
Google "Lab in a Suitcase". There are several people using that term since I first saw it being used in connection with Josh Quick's 2016 paper about nanopore sequencing in West Africa during the Ebola outbreak.

www.nature.com/articles/nat...
Real-time, portable genome sequencing for Ebola surveillance - Nature
A nanopore DNA sequencer is used for real-time genomic surveillance of the Ebola virus epidemic in the field in Guinea; the authors demonstrate that it is possible to pack a genomic surveillance labor...
www.nature.com
May 2, 2025 at 10:40 PM
Cool! Honestly though, someone needs to put this all in one device but in a sealed, vibration/impact resistant Pelican case.

Why?

Instant DNA sequencing results anywhere in the world in hours.

www.youtube.com/watch?v=cd8D...
MiniPcr 16 and BlueBox unboxing and walkthrough from MiniPCR BIO
YouTube video by CanYouBio
www.youtube.com
May 2, 2025 at 10:26 PM
1 hour and 35 min annnnnd I'll personally own a quite-likely functional Illumina MiSeq DNA Sequencer.
April 15, 2025 at 6:27 PM