Autoimmune🦋
@autoimmuneaware.bsky.social
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Reposted by Autoimmune🦋
acr-journals.bsky.social
Mechanisms of prothrombotic cell activation by anti-β2GPI IgG. The diagram highlights the receptors most commonly linked to cell activation by β2GPI/anti-β2GPI IgG surface complexes, as well as some effectors known to be downstream of that activation

#Rheumsky #Immunosky
Mechanisms of prothrombotic cell activation by anti-β2GPI IgG. The diagram highlights the receptors most commonly linked to cell activation by β2GPI/anti-β2GPI IgG surface complexes, as well as some effectors known to be downstream of that activation. β2GPI: beta-2 glycoprotein I, LRP: low-density lipoprotein receptor-related protein, ROS: reactive oxygen species, TF: tissue factor, TLR: Toll-like receptor, and VWF, von Willebrand factor
autoimmuneaware.bsky.social
Non-Criteria Obstetric Antiphospholipid Syndrome: Myth or Reality?

NC-OAPS: heterogeneous condition and ambiguously described in literature

#APS #OAPS #Pregnancy #autoimmune
mdpi-res.com
Reposted by Autoimmune🦋
autoimmuneaware.bsky.social
Behçet syndrome

🩸systemic #vasculitis, affects vessels of all calibers
🩺 venous #thrombosis with arterial #aneurysms, inflammatory parenchymal brain involvement, posterior #uveitis with retinal vasculitis, bipolar #ulcers and erythema nodosum
⁉️ controversy: pathergy test or HLA-B*51 in diagnosis
www.sciencedirect.com
autoimmuneaware.bsky.social
🧬Monogenic vasculitis: DADA2, HA20, SAVI, COPA, LAVLI, VEXAS—rare but real
🧠DADA2: Livedo racemosa, strokes, skin necrosis
🧠 HA20: Behçet-like—ulcers, uveitis, venous thrombosis.
🧠SAVI: Skin ulcers, nasal perforation
🧠COPA: Skin/intestinal vasculitis, ILD
🧠VEXAS
autoimmuneaware.bsky.social
🚨2024 American College of Rheumatology (ACR)
Guideline for the Screening, Treatment, and
Management of Lupus Nephritis

#Lupus #Nephritis #Guideline #Treatment #SLE

assets.contentstack.io/v3/assets/bl...
assets.contentstack.io
autoimmuneaware.bsky.social
Consensus nomenclature and abbreviation for anti-synthetase syndrome: an IMACS project

🚩lack of uniform terminology and abbreviations = challenges in research and clinical practice
🏳️anti-synthetase syndrome and ASyS should be adopted as the standard nomenclature
academic.oup.com/rheumatology...
Consensus nomenclature and abbreviation for anti-synthetase syndrome: an IMACS project
ABSTRACTObjectives. The lack of uniform terminology and abbreviations for anti-synthetase syndrome has led to significant challenges in research and clinic
academic.oup.com
autoimmuneaware.bsky.social
Remnant cholesterol predicts risk
of recurrent thrombosis beyond LDL‑cholesterol
in patients with antiphospholipid syndrome

🟠RC ➡️ increased risk of trombosis
🟠RC marker for thrombotic risk❓
🟠potential target
for therapeutic intervention.

bmcmedicine.biomedcentral.com/counter/pdf/...
bmcmedicine.biomedcentral.com
autoimmuneaware.bsky.social
EULAR recommendations for use of antirheumatic
drugs in reproduction, pregnancy, and lactation: 2024
update

🤰🏽👩🏽‍🍼

ard.eular.org/action/showP...
ard.eular.org
autoimmuneaware.bsky.social
IL-10 in Systemic Lupus Erythematosus: Balancing Immunoregulation and Autoimmunity

🔑involved in inflammatory and immune processes in SLE.
🔹IL-10 did not correlate with disease activity, organ in-
volvement, or treatment response.

www.mdpi.com/1422-0067/26...
www.mdpi.com
autoimmuneaware.bsky.social
Therapeutic approaches for
#SAPHO syndrome from the
perspective of pathogenesis:
a review of the literature

🔸Autoinflammatory
🔸cutaneous & osteoarticular
🔹ATB, tonsillectomy
🔹DMARDs
🔹Bisphosphonates

www.frontiersin.org/journals/imm...
www.frontiersin.org
autoimmuneaware.bsky.social
Prognostic insights from symptom clustering analysis in systemic lupus erythematosus

1️⃣ Articular/mucocutaneous ➡️better survival
2️⃣Severe phenotype with renal involvement ➡️ poor prognosis
3️⃣Mixed connective tissue disease-like features with anti-U1-RNP antibodies

rmdopen.bmj.com/content/11/2...
Prognostic insights from symptom clustering analysis in systemic lupus erythematosus
Objective Systemic lupus erythematosus (SLE), a systemic autoimmune disease with heterogeneous severity, poses a challenge in classifying patients due to its dynamic phenotype. We therefore aimed to i...
rmdopen.bmj.com
autoimmuneaware.bsky.social
Urine Protein Tests in Systemic Lupus Erythematosus:
What Do They Mean?

#SLE #Lupus #LN

www.jrheum.org/content/jrhe...
www.jrheum.org
autoimmuneaware.bsky.social
A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis

📌In patients with giant-cell arteritis, upadacitinib at a dose of 15 mg — but not 7.5 mg — with a 26-week glucocorticoid taper showed efficacy superior to that of placebo with a 52-week glucocorticoid taper

www.nejm.org/doi/full/10....
A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis | NEJM
Giant-cell arteritis is a systemic vasculitis with limited treatment options. The efficacy and safety of upadacitinib — a selective Janus kinase (JAK) inhibitor that blocks the signaling of several...
www.nejm.org