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Ben Davis Group

@bendavisgroup.bsky.social

33 followers 5 following 16 posts

Chemical Biology at the University of Oxford and the Rosalind Franklin Institute "There is hope in honest error." bendavis.group http://orcid.org/0000-0002-5056-407X https://scholar.google.co.uk/citations?hl=en&user=llfD9gsAAAAJ

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Ben Davis Group @bendavisgroup.bsky.social · Aug 15

www.nature.com/articles/s41...

Covalently constrained ‘Di-Gembodies’ enable parallel structure solutions by cryo-EM - Nature Chemical Biology

Disulfide-based dimerization of modified identical and heterologous nanobody scaffolds enables higher-order assembly for high-resolution cryo-electron microscopy structure determination that is widely...

www.nature.com

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Ben Davis Group @bendavisgroup.bsky.social · Aug 13

www.biorxiv.org/content/10.1...

Biomolecular tracking by FIRESCAPE reveals distinct modes of clearance, damage induction and cellular uptake for extracellular histone H3

In attempting to observe the behaviour of a protein of interest in vivo, akin to other observer effects, current techniques require modifications or interventions that inherently alter the protein or ...

www.biorxiv.org

Ben Davis Group @bendavisgroup.bsky.social · Aug 8

www.nature.com/articles/s41...

Seedless: on-the-fly pulse calculation for NMR experiments - Nature Communications

The authors develop a computational tool to design NMR pulses, based on the GRadient Assisted Pulse Engineering approach, that can calculate optimal pulse shapes on the fly during the measurements, to...

www.nature.com

Ben Davis Group @bendavisgroup.bsky.social · Aug 6

BGD has been awarded the ICS's Barry Cohen Award for Excellence in Medicinal Chemistry for 2025. www.chemistry.org.il/prizes-page/...

Ben Davis Group @bendavisgroup.bsky.social · Aug 6

www.biorxiv.org/content/10.1...

Live-cell 3D-SIM of Rift Valley fever virus NSs filaments reveals a polygonal web architecture

A defining feature of Rift Valley fever virus (RVFV) is the incorporation of the NSs protein into large filamentous assemblies inside infected nuclei [1][1], as judged from fixed specimens. To gain in...

www.biorxiv.org

Ben Davis Group @bendavisgroup.bsky.social · Jul 1

www.nature.com/articles/s41...

Thio-NHS esters are non-innocent protein acylating reagents - Nature Communications

N-Hydroxysuccinimide (NHS)-ester derivatives are one of the most widely used acylating agents. In this work, the authors report that ring-opening reaction of the succinimide to afford N-succinamide de...

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Ben Davis Group @bendavisgroup.bsky.social · Jun 26

www.nature.com/articles/s41...

Small-molecule dissolution of stress granules by redox modulation benefits ALS models - Nature Chemical Biology

Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...

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Ben Davis Group @bendavisgroup.bsky.social · Jun 26

www.nature.com/articles/s41...

Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials - Nature Biotechnology

A sunlight-activated chemical spray increases wheat yield in field trials across rainfall conditions.

www.nature.com

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Ben Davis Group @bendavisgroup.bsky.social · May 3

www.ox.ac.uk/news/2025-04...

New biostimulant treatment significantly boosts wheat yields, field

A novel biostimulant could deliver increased wheat yields of up to 12%, according to researchers from Oxford University, Rothamsted, and the Rosalind Franklin Institute in a long-term study published

www.ox.ac.uk

Ben Davis Group @bendavisgroup.bsky.social · Apr 29

www.bbc.co.uk/programmes/m...

BBC Radio 4 - Farming Today, 30/4/25 Welsh community food strategy, British-grown pulses, biostimulant for wheat

New community food strategy for Wales.

www.bbc.co.uk

Ben Davis Group @bendavisgroup.bsky.social · Apr 8

Addressing NHS chemistry: Efficient quenching of excess TMT reagent and reversing TMT-over labelling in proteomic samples by methylamine, Mol Cell Proteomics, 2025, 24(4), 100948, doi.org/10.1016/j.mc...

Ben Davis Group @bendavisgroup.bsky.social · Mar 31

BGD has been awarded the ACS's Hudson Award for 2025. acscarb.org/awards/hudso...

Ben Davis Group @bendavisgroup.bsky.social · Mar 1

Isostere 18F-protein post-translational editing enables dynamic tracking of neurodegeneration biomarkers, bioRxiv 2025.01.26.634877; doi: doi.org/10.1101/2025...

Isostere 18F-protein post-translational editing enables dynamic tracking of neurodegeneration biomarkers

The neurofilament light chain protein (NfL) is a suggested general marker for neuronal loss. Its release from brain parenchyma into cerebral spinal fluid, and presumed detection in blood has seen it e...

doi.org

Ben Davis Group @bendavisgroup.bsky.social · Mar 1

Lipid-Modulated, Graduated Inhibition of N-Glycosylation Pathway Priming Suggests Wide Tolerance of ER Proteostasis to Stress, ACS Cent. Sci., 2025, 11, 107-115, doi.org/10.1021/acsc...

Lipid-Modulated, Graduated Inhibition of N-Glycosylation Pathway Priming Suggests Wide Tolerance of ER Proteostasis to Stress

Protein N-glycosylation is a cotranslational modification that takes place in the endoplasmic reticulum (ER). Disruption of this process can result in accumulation of misfolded proteins, known as ER s...

doi.org

Ben Davis Group @bendavisgroup.bsky.social · Mar 1

Structure of WzxE the Lipid III Flippase for Enterobacterial Common Antigen Polysaccharide, Open. Biol., 2025, 15, 240310, doi.org/10.1098/rsob...

Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide | Open Biology

The enterobacterial common antigen (ECA) is conserved in Gram-negative bacteria of the Enterobacterales order although its function is debated. ECA biogenesis depends on the Wzx/Wzy-dependent strategy...

doi.org

Ben Davis Group @bendavisgroup.bsky.social · Mar 1

Start with some...Thoughts for the Future, Nature Chemical Biology, 2025, 21, 6-15; doi.org/10.1038/s415...

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